Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
Identifieur interne : 003566 ( Ncbi/Merge ); précédent : 003565; suivant : 003567Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
Auteurs : Gordon Fehringer [Canada] ; Peter Kraft ; Paul D. Pharoah [Royaume-Uni] ; Rosalind A. Eeles [Royaume-Uni] ; Nilanjan Chatterjee [États-Unis] ; Fred Schumacher [États-Unis] ; Joellen Schildkraut [États-Unis] ; Sara Lindström ; Paul Brennan [France] ; Heike Bickeböller [Allemagne] ; Richard S. Houlston [Royaume-Uni] ; Maria Teresa Landi [États-Unis] ; Neil Caporaso [États-Unis] ; Angela Risch [Autriche, Allemagne] ; Ali Amin Al Olama [Royaume-Uni] ; Sonja I. Berndt [États-Unis] ; Edward Giovannucci ; Henrik Grönberg [Suède] ; Zsofia Kote-Jarai [Royaume-Uni] ; Jing Ma ; Kenneth Muir [Royaume-Uni] ; Meir Stampfer ; Victoria L. Stevens ; Fredrik Wiklund [Suède] ; Walter Willett ; Ellen L. Goode ; Jennifer Permuth [États-Unis] ; Harvey A. Risch [États-Unis] ; Brett M. Reid [États-Unis] ; Stephane Bezieau [France] ; Hermann Brenner [Allemagne] ; Andrew T. Chan [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Thomas J. Hudson ; Jonathan K. Kocarnik [États-Unis] ; Polly A. Newcomb [États-Unis] ; Robert E. Schoen [États-Unis] ; Martha L. Slattery [États-Unis] ; Emily White [États-Unis] ; Muriel A. Adank [Pays-Bas] ; Habibul Ahsan [États-Unis] ; Kristiina Aittom Ki [Finlande] ; Laura Baglietto [Australie] ; Carl Blomquist [Finlande] ; Federico Canzian [Allemagne] ; Kamila Czene [Suède] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; A. Heather Eliassen ; Jonine Figueroa [États-Unis] ; Dieter Flesch-Janys ; Olivia Fletcher [Royaume-Uni] ; Montserrat Garcia-Closas [États-Unis] ; Mia M. Gaudet ; Nichola Johnson [Royaume-Uni] ; Per Hall [Suède] ; Aditi Hazra ; Rebecca Hein [Allemagne] ; Albert Hofman [Pays-Bas] ; John L. Hopper [Australie] ; Astrid Irwanto [Singapour] ; Mattias Johansson [France] ; Rudolf Kaaks [Allemagne] ; Muhammad G. Kibriya [États-Unis] ; Peter Lichtner [Allemagne] ; Jianjun Liu [Singapour] ; Eiliv Lund [Norvège] ; Enes Makalic [Australie] ; Alfons Meindl [Allemagne] ; Bertram Müller-Myhsok [Allemagne] ; Taru A. Muranen [Finlande] ; Heli Nevanlinna [Finlande] ; Petra H. Peeters ; Julian Peto [Royaume-Uni] ; Ross L. Prentice [États-Unis] ; Nazneen Rahman [Royaume-Uni] ; Maria Jose Sanchez [Espagne] ; Daniel F. Schmidt [Australie] ; Rita K. Schmutzler [Allemagne] ; Melissa C. Southey [Australie] ; Rulla Tamimi ; Ruth C. Travis [Royaume-Uni] ; Clare Turnbull [Royaume-Uni] ; Andre G. Uitterlinden [Pays-Bas] ; Zhaoming Wang [États-Unis] ; Alice S. Whittemore [États-Unis] ; Xiaohong R. Yang [États-Unis] ; Wei Zheng [États-Unis] ; Thorunn Rafnar [Islande] ; Julius Gudmundsson [Islande] ; Simon N. Stacey [Islande] ; Kari Stefansson [Islande] ; Patrick Sulem [Islande] ; Y. Ann Chen [États-Unis] ; Jonathan P. Tyrer [Royaume-Uni] ; David C. Christiani ; Yongyue Wei ; Hongbing Shen [République populaire de Chine] ; Zhibin Hu [République populaire de Chine] ; Xiao-Ou Shu [États-Unis] ; Kouya Shiraishi [Japon] ; Atsushi Takahashi [Japon] ; Yohan Bossé [Canada] ; Ma N Obeidat [Canada] ; David Nickle [États-Unis] ; Wim Timens [Pays-Bas] ; Matthew L. Freedman [États-Unis] ; Qiyuan Li ; Daniela Seminara [États-Unis] ; Stephen J. Chanock [États-Unis] ; Jian Gong [États-Unis] ; Ulrike Peters [États-Unis] ; Stephen B. Gruber [États-Unis] ; Christopher I. Amos [Liban] ; Thomas A. Sellers [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; David J. Hunter ; Christopher A. Haiman [États-Unis] ; Brian E. Henderson [États-Unis] ; Rayjean J. Hung [Canada]Source :
- Cancer research [ 0008-5472 ] ; 2016.
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Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with
Url:
DOI: 10.1158/0008-5472.CAN-15-2980
PubMed: 27197191
PubMed Central: 5010493
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Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff><wicri:noCountry code="subfield">Rochester Minnesota</wicri:noCountry></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff><wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff><wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff><wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff><wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea><wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea><wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff><wicri:noCountry code="subfield">Xiamen China</wicri:noCountry></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea><wicri:noRegion>Dartmouth College</wicri:noRegion></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27197191</idno><idno type="pmc">5010493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493</idno><idno type="RBID">PMC:5010493</idno><idno type="doi">10.1158/0008-5472.CAN-15-2980</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001F15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F15</idno><idno type="wicri:Area/Pmc/Curation">001D71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D71</idno><idno type="wicri:Area/Pmc/Checkpoint">000A39</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A39</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001991</idno><idno type="wicri:Area/PubMed/Curation">001967</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001967</idno><idno type="wicri:Area/PubMed/Checkpoint">001967</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001967</idno><idno type="wicri:Area/Ncbi/Merge">003566</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name><affiliation wicri:level="1"><nlm:aff id="A7">University of Virginia, Charlottesville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Virginia, Charlottesville</wicri:regionArea><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:aff id="A9">University of Göttingen, Medical School, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name><affiliation wicri:level="1"><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="4"><nlm:aff id="A16">University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff><wicri:noCountry code="subfield">Rochester Minnesota</wicri:noCountry></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff><wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff><wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff><wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff><wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea><wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea><wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff><wicri:noCountry code="subfield">Xiamen China</wicri:noCountry></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea><wicri:noRegion>Dartmouth College</wicri:noRegion></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term><term>Colorectal Neoplasms (genetics)</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Lung Neoplasms (genetics)</term><term>Male</term><term>Ovarian Neoplasms (genetics)</term><term>Prostatic Neoplasms (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs de l'ovaire (génétique)</term><term>Tumeurs de la prostate (génétique)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du sein (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Lung Neoplasms</term><term>Ovarian Neoplasms</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term><term>Tumeurs de l'ovaire</term><term>Tumeurs de la prostate</term><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with <italic>ADAM15/THBS3</italic> gene expression in lung. We also identified a known breast cancer locus <italic>CASP8/ALS2CR12</italic> associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast <italic>BRCA2</italic> locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.</p></div></front></TEI><double pmid="27197191"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name><affiliation wicri:level="1"><nlm:aff id="A7">University of Virginia, Charlottesville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Virginia, Charlottesville</wicri:regionArea><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:aff id="A9">University of Göttingen, Medical School, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name><affiliation wicri:level="1"><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="4"><nlm:aff id="A16">University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff><wicri:noCountry code="subfield">Rochester Minnesota</wicri:noCountry></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff><wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff><wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff><wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff><wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea><wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea><wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff><wicri:noCountry code="subfield">Xiamen China</wicri:noCountry></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea><wicri:noRegion>Dartmouth College</wicri:noRegion></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27197191</idno><idno type="pmc">5010493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493</idno><idno type="RBID">PMC:5010493</idno><idno type="doi">10.1158/0008-5472.CAN-15-2980</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001F15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F15</idno><idno type="wicri:Area/Pmc/Curation">001D71</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D71</idno><idno type="wicri:Area/Pmc/Checkpoint">000A39</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name><affiliation wicri:level="1"><nlm:aff id="A7">University of Virginia, Charlottesville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Virginia, Charlottesville</wicri:regionArea><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:aff id="A9">University of Göttingen, Medical School, Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea><wicri:noRegion>Salzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name><affiliation wicri:level="1"><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="4"><nlm:aff id="A16">University of Manchester, Manchester, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff><wicri:noCountry code="subfield">Rochester Minnesota</wicri:noCountry></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale School of Public Health, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff><wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea><placeName><settlement type="city">Pittsburgh</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff><wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff><wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion><wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff><wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff><wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea><wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea><wicri:noRegion>Nashville</wicri:noRegion></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea><wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff><wicri:noCountry code="subfield">Xiamen China</wicri:noCountry></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea><wicri:noRegion>Bethesda</wicri:noRegion></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea><wicri:noRegion>Seattle</wicri:noRegion></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff><country xml:lang="fr">Liban</country><wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea><wicri:noRegion>Dartmouth College</wicri:noRegion></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea><wicri:noRegion>Tampa</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff><wicri:noCountry code="subfield">Boston MA</wicri:noCountry></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with <italic>ADAM15/THBS3</italic> gene expression in lung. We also identified a known breast cancer locus <italic>CASP8/ALS2CR12</italic> associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast <italic>BRCA2</italic> locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D" last="Pharoah">Paul D. Pharoah</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A" last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation wicri:level="2"><nlm:affiliation>University of Virginia, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:affiliation>University of Göttingen, Medical School, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge University, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="4"><nlm:affiliation>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C" last="Willett">Walter C. Willett</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Permuth, Jennifer B" sort="Permuth, Jennifer B" uniqKey="Permuth J" first="Jennifer B" last="Permuth">Jennifer B. Permuth</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:affiliation>Yale School of Public Health, New Haven, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale School of Public Health, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M" last="Reid">Brett M. Reid</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:affiliation>Service de Génétique Médicale, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="2"><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Ontario Institute for Cancer Research, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K" last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>University of Utah Health Sciences Center, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A Heather" last="Eliassen">A Heather Eliassen</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea</wicri:regionArea><wicri:noRegion>Umea</wicri:noRegion></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:affiliation>German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:affiliation>Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="3"><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R" last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Buchanan, Daniel D" sort="Buchanan, Daniel D" uniqKey="Buchanan D" first="Daniel D" last="Buchanan">Daniel D. Buchanan</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="2"><nlm:affiliation>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Mayo Clinic, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O" last="Woods">Michael O. Woods</name><affiliation wicri:level="1"><nlm:affiliation>Memorial University of Newfoundland, St. John's, Newfoundland, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Memorial University of Newfoundland, St. John's, Newfoundland</wicri:regionArea><wicri:noRegion>Newfoundland</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y Ann" last="Chen">Y Ann Chen</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Merck Research Laboratories, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Merck & Co, Merck Research Laboratories, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:affiliation>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation wicri:level="1"><nlm:affiliation>Xiamen University, Xiamen, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiamen University, Xiamen</wicri:regionArea><wicri:noRegion>Xiamen</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:affiliation>Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea>Geisel School of Medicine, Dartmouth College, Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A" last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27197191</idno><idno type="pmid">27197191</idno><idno type="doi">10.1158/0008-5472.CAN-15-2980</idno><idno type="wicri:Area/PubMed/Corpus">001991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001991</idno><idno type="wicri:Area/PubMed/Curation">001967</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001967</idno><idno type="wicri:Area/PubMed/Checkpoint">001967</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001967</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D" last="Pharoah">Paul D. Pharoah</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A" last="Eeles">Rosalind A. Eeles</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation wicri:level="2"><nlm:affiliation>University of Virginia, Charlottesville, Virginia.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>University of Virginia, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation wicri:level="3"><nlm:affiliation>University of Göttingen, Medical School, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation wicri:level="1"><nlm:affiliation>Cambridge University, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation wicri:level="4"><nlm:affiliation>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry</wicri:regionArea><orgName type="university">Université de Manchester</orgName><placeName><settlement type="city">Manchester</settlement><region type="nation">Angleterre</region><region nuts="2" type="region">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C" last="Willett">Walter C. Willett</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Permuth, Jennifer B" sort="Permuth, Jennifer B" uniqKey="Permuth J" first="Jennifer B" last="Permuth">Jennifer B. Permuth</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation wicri:level="2"><nlm:affiliation>Yale School of Public Health, New Haven, Connecticut.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Yale School of Public Health, New Haven</wicri:cityArea></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M" last="Reid">Brett M. Reid</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation wicri:level="3"><nlm:affiliation>Service de Génétique Médicale, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation wicri:level="2"><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation wicri:level="2"><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario.</nlm:affiliation><country>Canada</country><placeName><region type="province">Ontario</region></placeName><wicri:cityArea>Ontario Institute for Cancer Research, Toronto</wicri:cityArea></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K" last="Kocarnik">Jonathan K. Kocarnik</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation wicri:level="2"><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>University of Utah Health Sciences Center, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation wicri:level="3"><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation wicri:level="3"><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A Heather" last="Eliassen">A Heather Eliassen</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation wicri:level="3"><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation wicri:level="1"><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Epidemiology Research Program, American Cancer Society, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation wicri:level="3"><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation wicri:level="3"><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation wicri:level="1"><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation wicri:level="1"><nlm:affiliation>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea</wicri:regionArea><wicri:noRegion>Umea</wicri:noRegion></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation wicri:level="3"><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation wicri:level="2"><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation wicri:level="1"><nlm:affiliation>German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation wicri:level="1"><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Genome Institute of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso</wicri:regionArea><wicri:noRegion>Tromso</wicri:noRegion></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation wicri:level="4"><nlm:affiliation>Technische Universität München, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Technische Universität München, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université technique de Munich</orgName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation wicri:level="1"><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</wicri:regionArea><wicri:noRegion>University Medical Center Utrecht</wicri:noRegion></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="3"><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation wicri:level="3"><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation wicri:level="1"><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Cologne, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation><wicri:noCountry code="subField">Boston Massachusetts</wicri:noCountry></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea><wicri:noRegion>Sutton</wicri:noRegion></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R" last="Yang">Xiaohong R. Yang</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Buchanan, Daniel D" sort="Buchanan, Daniel D" uniqKey="Buchanan D" first="Daniel D" last="Buchanan">Daniel D. Buchanan</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation wicri:level="2"><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Stanford University, Stanford</wicri:cityArea></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name><affiliation wicri:level="2"><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>Epidemiology Program, University of Hawaii Cancer Center, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="2"><nlm:affiliation>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Mayo Clinic, Scottsdale</wicri:cityArea></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O" last="Woods">Michael O. Woods</name><affiliation wicri:level="1"><nlm:affiliation>Memorial University of Newfoundland, St. John's, Newfoundland, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Memorial University of Newfoundland, St. John's, Newfoundland</wicri:regionArea><wicri:noRegion>Newfoundland</wicri:noRegion></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y Ann" last="Chen">Y Ann Chen</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation wicri:level="1"><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation wicri:level="1"><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation wicri:level="2"><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation wicri:level="3"><nlm:affiliation>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation wicri:level="1"><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation wicri:level="2"><nlm:affiliation>Merck & Co, Merck Research Laboratories, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Merck & Co, Merck Research Laboratories, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation wicri:level="4"><nlm:affiliation>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation wicri:level="1"><nlm:affiliation>Xiamen University, Xiamen, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Xiamen University, Xiamen</wicri:regionArea><wicri:noRegion>Xiamen</wicri:noRegion></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation wicri:level="2"><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Cancer Instititute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation wicri:level="2"><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation wicri:level="2"><nlm:affiliation>Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Hampshire</region></placeName><wicri:cityArea>Geisel School of Medicine, Dartmouth College, Hanover</wicri:cityArea></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A" last="Sellers">Thomas A. Sellers</name><affiliation wicri:level="2"><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Moffitt Cancer Center, Tampa</wicri:cityArea></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation wicri:level="2"><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard T.H. Chan School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation wicri:level="2"><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation wicri:level="1"><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term><term>Colorectal Neoplasms (genetics)</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Lung Neoplasms (genetics)</term><term>Male</term><term>Ovarian Neoplasms (genetics)</term><term>Prostatic Neoplasms (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Tumeurs colorectales (génétique)</term><term>Tumeurs de l'ovaire (génétique)</term><term>Tumeurs de la prostate (génétique)</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du sein (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Lung Neoplasms</term><term>Ovarian Neoplasms</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term><term>Tumeurs de l'ovaire</term><term>Tumeurs de la prostate</term><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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