Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Identifieur interne : 001991 ( PubMed/Corpus ); précédent : 001990; suivant : 001992Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
Auteurs : Gordon Fehringer ; Peter Kraft ; Paul D. Pharoah ; Rosalind A. Eeles ; Nilanjan Chatterjee ; Fredrick R. Schumacher ; Joellen M. Schildkraut ; Sara Lindström ; Paul Brennan ; Heike Bickeböller ; Richard S. Houlston ; Maria Teresa Landi ; Neil Caporaso ; Angela Risch ; Ali Amin Al Olama ; Sonja I. Berndt ; Edward L. Giovannucci ; Henrik Grönberg ; Zsofia Kote-Jarai ; Jing Ma ; Kenneth Muir ; Meir J. Stampfer ; Victoria L. Stevens ; Fredrik Wiklund ; Walter C. Willett ; Ellen L. Goode ; Jennifer B. Permuth ; Harvey A. Risch ; Brett M. Reid ; Stephane Bezieau ; Hermann Brenner ; Andrew T. Chan ; Jenny Chang-Claude ; Thomas J. Hudson ; Jonathan K. Kocarnik ; Polly A. Newcomb ; Robert E. Schoen ; Martha L. Slattery ; Emily White ; Muriel A. Adank ; Habibul Ahsan ; Kristiina Aittom Ki ; Laura Baglietto ; Carl Blomquist ; Federico Canzian ; Kamila Czene ; Isabel Dos-Santos-Silva ; A Heather Eliassen ; Jonine D. Figueroa ; Dieter Flesch-Janys ; Olivia Fletcher ; Montserrat Garcia-Closas ; Mia M. Gaudet ; Nichola Johnson ; Per Hall ; Aditi Hazra ; Rebecca Hein ; Albert Hofman ; John L. Hopper ; Astrid Irwanto ; Mattias Johansson ; Rudolf Kaaks ; Muhammad G. Kibriya ; Peter Lichtner ; Jianjun Liu ; Eiliv Lund ; Enes Makalic ; Alfons Meindl ; Bertram Müller-Myhsok ; Taru A. Muranen ; Heli Nevanlinna ; Petra H. Peeters ; Julian Peto ; Ross L. Prentice ; Nazneen Rahman ; Maria Jose Sanchez ; Daniel F. Schmidt ; Rita K. Schmutzler ; Melissa C. Southey ; Rulla Tamimi ; Ruth C. Travis ; Clare Turnbull ; Andre G. Uitterlinden ; Zhaoming Wang ; Alice S. Whittemore ; Xiaohong R. Yang ; Wei Zheng ; Daniel D. Buchanan ; Graham Casey ; David V. Conti ; Christopher K. Edlund ; Steven Gallinger ; Robert W. Haile ; Mark Jenkins ; Loïc Le Marchand ; Li Li ; Noralene M. Lindor ; Stephanie L. Schmit ; Stephen N. Thibodeau ; Michael O. Woods ; Thorunn Rafnar ; Julius Gudmundsson ; Simon N. Stacey ; Kari Stefansson ; Patrick Sulem ; Y Ann Chen ; Jonathan P. Tyrer ; David C. Christiani ; Yongyue Wei ; Hongbing Shen ; Zhibin Hu ; Xiao-Ou Shu ; Kouya Shiraishi ; Atsushi Takahashi ; Yohan Bossé ; Ma'En Obeidat ; David Nickle ; Wim Timens ; Matthew L. Freedman ; Qiyuan Li ; Daniela Seminara ; Stephen J. Chanock ; Jian Gong ; Ulrike Peters ; Stephen B. Gruber ; Christopher I. Amos ; Thomas A. Sellers ; Douglas F. Easton ; David J. Hunter ; Christopher A. Haiman ; Brian E. Henderson ; Rayjean J. HungSource :
- Cancer research [ 1538-7445 ] ; 2016.
English descriptors
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- MESH :
Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.
DOI: 10.1158/0008-5472.CAN-15-2980
PubMed: 27197191
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pubmed:27197191Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D" last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A" last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:affiliation>University of Virginia, Charlottesville, Virginia.</nlm:affiliation></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:affiliation>University of Göttingen, Medical School, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:affiliation>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation><nlm:affiliation>Cambridge University, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:affiliation>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C" last="Willett">Walter C. Willett</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Permuth, Jennifer B" sort="Permuth, Jennifer B" uniqKey="Permuth J" first="Jennifer B" last="Permuth">Jennifer B. Permuth</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation><nlm:affiliation>Yale School of Public Health, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M" last="Reid">Brett M. Reid</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:affiliation>Service de Génétique Médicale, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario.</nlm:affiliation></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K" last="Kocarnik">Jonathan K. Kocarnik</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, Utah.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A Heather" last="Eliassen">A Heather Eliassen</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:affiliation>University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:affiliation>German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:affiliation>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:affiliation>Technische Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R" last="Yang">Xiaohong R. Yang</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Buchanan, Daniel D" sort="Buchanan, Daniel D" uniqKey="Buchanan D" first="Daniel D" last="Buchanan">Daniel D. Buchanan</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation><nlm:affiliation>Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O" last="Woods">Michael O. Woods</name><affiliation><nlm:affiliation>Memorial University of Newfoundland, St. John's, Newfoundland, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y Ann" last="Chen">Y Ann Chen</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation><nlm:affiliation>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:affiliation>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation><nlm:affiliation>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation><nlm:affiliation>Merck & Co, Merck Research Laboratories, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation><nlm:affiliation>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name><affiliation><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:affiliation>Xiamen University, Xiamen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation><nlm:affiliation>Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.</nlm:affiliation></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A" last="Sellers">Thomas A. Sellers</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27197191</idno><idno type="pmid">27197191</idno><idno type="doi">10.1158/0008-5472.CAN-15-2980</idno><idno type="wicri:Area/PubMed/Corpus">001991</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001991</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D" last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A" last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:affiliation>University of Virginia, Charlottesville, Virginia.</nlm:affiliation></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:affiliation>University of Göttingen, Medical School, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S" last="Houlston">Richard S. Houlston</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:affiliation>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Amin Al Olama, Ali" sort="Amin Al Olama, Ali" uniqKey="Amin Al Olama A" first="Ali" last="Amin Al Olama">Ali Amin Al Olama</name><affiliation><nlm:affiliation>Cambridge University, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:affiliation>Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:affiliation>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L" last="Stevens">Victoria L. Stevens</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Willett, Walter C" sort="Willett, Walter C" uniqKey="Willett W" first="Walter C" last="Willett">Walter C. Willett</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Permuth, Jennifer B" sort="Permuth, Jennifer B" uniqKey="Permuth J" first="Jennifer B" last="Permuth">Jennifer B. Permuth</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A" last="Risch">Harvey A. Risch</name><affiliation><nlm:affiliation>Yale School of Public Health, New Haven, Connecticut.</nlm:affiliation></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M" last="Reid">Brett M. Reid</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:affiliation>Service de Génétique Médicale, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Massachusetts General Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, Ontario.</nlm:affiliation></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K" last="Kocarnik">Jonathan K. Kocarnik</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>University of Utah Health Sciences Center, Salt Lake City, Utah.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A" last="Adank">Muriel A. Adank</name><affiliation><nlm:affiliation>VU University Medical Center, Amsterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A Heather" last="Eliassen">A Heather Eliassen</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Figueroa, Jonine D" sort="Figueroa, Jonine D" uniqKey="Figueroa J" first="Jonine D" last="Figueroa">Jonine D. Figueroa</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:affiliation>University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M" last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:affiliation>Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G" last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:affiliation>University of Chicago, Chicago, Illinois.</nlm:affiliation></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:affiliation>German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:affiliation>Genome Institute of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:affiliation>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:affiliation>Technische Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A" last="Muranen">Taru A. Muranen</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L" last="Prentice">Ross L. Prentice</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F" last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K" last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:affiliation>University of Cologne, Cologne, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:affiliation>Harvard Medical School, Boston Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:affiliation>Institute of Cancer Research, Sutton, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G" last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R" last="Yang">Xiaohong R. Yang</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Buchanan, Daniel D" sort="Buchanan, Daniel D" uniqKey="Buchanan D" first="Daniel D" last="Buchanan">Daniel D. Buchanan</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Edlund, Christopher K" sort="Edlund, Christopher K" uniqKey="Edlund C" first="Christopher K" last="Edlund">Christopher K. Edlund</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation><nlm:affiliation>Stanford University, Stanford, California.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark" sort="Jenkins, Mark" uniqKey="Jenkins M" first="Mark" last="Jenkins">Mark Jenkins</name><affiliation><nlm:affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loïc" last="Le Marchand">Loïc Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Lindor, Noralene M" sort="Lindor, Noralene M" uniqKey="Lindor N" first="Noralene M" last="Lindor">Noralene M. Lindor</name><affiliation><nlm:affiliation>Mayo Clinic, Scottsdale, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Schmit, Stephanie L" sort="Schmit, Stephanie L" uniqKey="Schmit S" first="Stephanie L" last="Schmit">Stephanie L. Schmit</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Thibodeau, Stephen N" sort="Thibodeau, Stephen N" uniqKey="Thibodeau S" first="Stephen N" last="Thibodeau">Stephen N. Thibodeau</name><affiliation><nlm:affiliation>Mayo Clinic, Rochester, Minnesota.</nlm:affiliation></affiliation></author><author><name sortKey="Woods, Michael O" sort="Woods, Michael O" uniqKey="Woods M" first="Michael O" last="Woods">Michael O. Woods</name><affiliation><nlm:affiliation>Memorial University of Newfoundland, St. John's, Newfoundland, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N" last="Stacey">Simon N. Stacey</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y Ann" last="Chen">Y Ann Chen</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C" last="Christiani">David C. Christiani</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation><nlm:affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:affiliation>Vanderbilt University, Nashville, Tennessee.</nlm:affiliation></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation><nlm:affiliation>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:affiliation>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation><nlm:affiliation>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Obeidat, Ma En" sort="Obeidat, Ma En" uniqKey="Obeidat M" first="Ma'En" last="Obeidat">Ma'En Obeidat</name><affiliation><nlm:affiliation>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation><nlm:affiliation>Merck & Co, Merck Research Laboratories, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation><nlm:affiliation>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L" last="Freedman">Matthew L. Freedman</name><affiliation><nlm:affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:affiliation>Xiamen University, Xiamen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>National Cancer Instititute, Bethesda, Maryland.</nlm:affiliation></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B" last="Gruber">Stephen B. Gruber</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I" last="Amos">Christopher I. Amos</name><affiliation><nlm:affiliation>Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.</nlm:affiliation></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A" last="Sellers">Thomas A. Sellers</name><affiliation><nlm:affiliation>Moffitt Cancer Center, Tampa, Florida.</nlm:affiliation></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name><affiliation><nlm:affiliation>University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name><affiliation><nlm:affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A" last="Haiman">Christopher A. Haiman</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E" last="Henderson">Brian E. Henderson</name><affiliation><nlm:affiliation>University of Southern California, Los Angeles, California.</nlm:affiliation></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J" last="Hung">Rayjean J. Hung</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term><term>Colorectal Neoplasms (genetics)</term><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Lung Neoplasms (genetics)</term><term>Male</term><term>Ovarian Neoplasms (genetics)</term><term>Prostatic Neoplasms (genetics)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Colorectal Neoplasms</term><term>Lung Neoplasms</term><term>Ovarian Neoplasms</term><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27197191</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>02</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>24</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7445</ISSN><JournalIssue CitedMedium="Internet"><Volume>76</Volume><Issue>17</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Cancer research</Title><ISOAbbreviation>Cancer Res.</ISOAbbreviation></Journal><ArticleTitle>Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.</ArticleTitle><Pagination><MedlinePgn>5103-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/0008-5472.CAN-15-2980</ELocationID><Abstract><AbstractText>Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.</AbstractText><CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fehringer</LastName><ForeName>Gordon</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pharoah</LastName><ForeName>Paul D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eeles</LastName><ForeName>Rosalind A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatterjee</LastName><ForeName>Nilanjan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schumacher</LastName><ForeName>Fredrick R</ForeName><Initials>FR</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schildkraut</LastName><ForeName>Joellen M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>University of Virginia, Charlottesville, Virginia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindström</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bickeböller</LastName><ForeName>Heike</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Göttingen, Medical School, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houlston</LastName><ForeName>Richard S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landi</LastName><ForeName>Maria Teresa</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caporaso</LastName><ForeName>Neil</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Risch</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria. Division of Epigenomics and Cancer Risk Factors, DKFZ - German Cancer Research Center, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin Al Olama</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cambridge University, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grönberg</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kote-Jarai</LastName><ForeName>Zsofia</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston Massachusetts. Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muir</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Manchester, Manchester, United Kingdom. The University of Warwick, Coventry, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stampfer</LastName><ForeName>Meir J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stevens</LastName><ForeName>Victoria L</ForeName><Initials>VL</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiklund</LastName><ForeName>Fredrik</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willett</LastName><ForeName>Walter C</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goode</LastName><ForeName>Ellen L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Mayo Clinic, Rochester, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Permuth</LastName><ForeName>Jennifer B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Moffitt Cancer Center, Tampa, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Risch</LastName><ForeName>Harvey A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Yale School of Public Health, New Haven, Connecticut.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reid</LastName><ForeName>Brett M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Moffitt Cancer Center, Tampa, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bezieau</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Génétique Médicale, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Massachusetts General Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang-Claude</LastName><ForeName>Jenny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Ontario Institute for Cancer Research, Toronto, Ontario.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kocarnik</LastName><ForeName>Jonathan K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newcomb</LastName><ForeName>Polly A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schoen</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slattery</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>University of Utah Health Sciences Center, Salt Lake City, Utah.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adank</LastName><ForeName>Muriel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>VU University Medical Center, Amsterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahsan</LastName><ForeName>Habibul</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Chicago, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aittomäki</LastName><ForeName>Kristiina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baglietto</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blomquist</LastName><ForeName>Carl</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canzian</LastName><ForeName>Federico</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czene</LastName><ForeName>Kamila</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dos-Santos-Silva</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eliassen</LastName><ForeName>A Heather</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Harvard Medical School, Boston Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueroa</LastName><ForeName>Jonine D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flesch-Janys</LastName><ForeName>Dieter</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fletcher</LastName><ForeName>Olivia</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia-Closas</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaudet</LastName><ForeName>Mia M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Nichola</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Breakthrough Research Centre, The Institute of Cancer Research, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hazra</LastName><ForeName>Aditi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hein</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany. Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Irwanto</LastName><ForeName>Astrid</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Genome Institute of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johansson</LastName><ForeName>Mattias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer, Lyon, France. Department of Biobank Research, Umea University, Umea, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kibriya</LastName><ForeName>Muhammad G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>University of Chicago, Chicago, Illinois.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lichtner</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jianjun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Genome Institute of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lund</LastName><ForeName>Eiliv</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Makalic</LastName><ForeName>Enes</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meindl</LastName><ForeName>Alfons</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller-Myhsok</LastName><ForeName>Bertram</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muranen</LastName><ForeName>Taru A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nevanlinna</LastName><ForeName>Heli</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peeters</LastName><ForeName>Petra H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peto</LastName><ForeName>Julian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prentice</LastName><ForeName>Ross L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rahman</LastName><ForeName>Nazneen</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Cancer Research, Sutton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez</LastName><ForeName>Maria Jose</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Granada, Spain. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. CIBER de Epidemiología y Salud Pública CIBERESP, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Daniel F</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmutzler</LastName><ForeName>Rita K</ForeName><Initials>RK</Initials><AffiliationInfo><Affiliation>University of Cologne, Cologne, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southey</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamimi</LastName><ForeName>Rulla</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Harvard Medical School, Boston Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turnbull</LastName><ForeName>Clare</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cancer Research, Sutton, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>Andre G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaoming</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whittemore</LastName><ForeName>Alice S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Stanford University, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Xiaohong R</ForeName><Initials>XR</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Vanderbilt University, Nashville, Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buchanan</LastName><ForeName>Daniel D</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casey</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conti</LastName><ForeName>David V</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edlund</LastName><ForeName>Christopher K</ForeName><Initials>CK</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallinger</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haile</LastName><ForeName>Robert W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>Stanford University, Stanford, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loïc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Case Comprehensive Cancer Center and Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindor</LastName><ForeName>Noralene M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Mayo Clinic, Scottsdale, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmit</LastName><ForeName>Stephanie L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thibodeau</LastName><ForeName>Stephen N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Mayo Clinic, Rochester, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woods</LastName><ForeName>Michael O</ForeName><Initials>MO</Initials><AffiliationInfo><Affiliation>Memorial University of Newfoundland, St. John's, Newfoundland, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rafnar</LastName><ForeName>Thorunn</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudmundsson</LastName><ForeName>Julius</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stacey</LastName><ForeName>Simon N</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stefansson</LastName><ForeName>Kari</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sulem</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>deCODE genetics, Amgen, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Y Ann</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Moffitt Cancer Center, Tampa, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyrer</LastName><ForeName>Jonathan P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Christiani</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Yongyue</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Hongbing</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Zhibin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Nanjing Medical University School of Public Health, Nanjing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Xiao-Ou</ForeName><Initials>XO</Initials><AffiliationInfo><Affiliation>Vanderbilt University, Nashville, Tennessee.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shiraishi</LastName><ForeName>Kouya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takahashi</LastName><ForeName>Atsushi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bossé</LastName><ForeName>Yohan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obeidat</LastName><ForeName>Ma'en</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of British Columbia Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nickle</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Merck & Co, Merck Research Laboratories, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Timens</LastName><ForeName>Wim</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freedman</LastName><ForeName>Matthew L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Dana-Farber Cancer Institute, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Qiyuan</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Xiamen University, Xiamen, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seminara</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>National Cancer Instititute, Bethesda, Maryland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gong</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruber</LastName><ForeName>Stephen B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amos</LastName><ForeName>Christopher I</ForeName><Initials>CI</Initials><AffiliationInfo><Affiliation>Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sellers</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Moffitt Cancer Center, Tampa, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Easton</LastName><ForeName>Douglas F</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Harvard T.H. Chan School of Public Health, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haiman</LastName><ForeName>Christopher A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>Brian E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>University of Southern California, Los Angeles, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hung</LastName><ForeName>Rayjean J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada. rayjean.hung@lunenfeld.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Ovarian Cancer Association Consortium (OCAC)</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>PRACTICAL 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No potential conflicts of interest were disclosed by other authors.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>03</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27197191</ArticleId><ArticleId IdType="pii">0008-5472.CAN-15-2980</ArticleId><ArticleId IdType="doi">10.1158/0008-5472.CAN-15-2980</ArticleId><ArticleId IdType="pmc">PMC5010493</ArticleId><ArticleId IdType="mid">NIHMS780930</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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