Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
Identifieur interne : 001F15 ( Pmc/Corpus ); précédent : 001F14; suivant : 001F16Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
Auteurs : Gordon Fehringer ; Peter Kraft ; Paul D. Pharoah ; Rosalind A. Eeles ; Nilanjan Chatterjee ; Fred Schumacher ; Joellen Schildkraut ; Sara Lindström ; Paul Brennan ; Heike Bickeböller ; Richard S. Houlston ; Maria Teresa Landi ; Neil Caporaso ; Angela Risch ; Ali Amin Al Olama ; Sonja I. Berndt ; Edward Giovannucci ; Henrik Grönberg ; Zsofia Kote-Jarai ; Jing Ma ; Kenneth Muir ; Meir Stampfer ; Victoria L. Stevens ; Fredrik Wiklund ; Walter Willett ; Ellen L. Goode ; Jennifer Permuth ; Harvey A. Risch ; Brett M. Reid ; Stephane Bezieau ; Hermann Brenner ; Andrew T. Chan ; Jenny Chang-Claude ; Thomas J. Hudson ; Jonathan K. Kocarnik ; Polly A. Newcomb ; Robert E. Schoen ; Martha L. Slattery ; Emily White ; Muriel A. Adank ; Habibul Ahsan ; Kristiina Aittom Ki ; Laura Baglietto ; Carl Blomquist ; Federico Canzian ; Kamila Czene ; Isabel Dos-Santos-Silva ; A. Heather Eliassen ; Jonine Figueroa ; Dieter Flesch-Janys ; Olivia Fletcher ; Montserrat Garcia-Closas ; Mia M. Gaudet ; Nichola Johnson ; Per Hall ; Aditi Hazra ; Rebecca Hein ; Albert Hofman ; John L. Hopper ; Astrid Irwanto ; Mattias Johansson ; Rudolf Kaaks ; Muhammad G. Kibriya ; Peter Lichtner ; Jianjun Liu ; Eiliv Lund ; Enes Makalic ; Alfons Meindl ; Bertram Müller-Myhsok ; Taru A. Muranen ; Heli Nevanlinna ; Petra H. Peeters ; Julian Peto ; Ross L. Prentice ; Nazneen Rahman ; Maria Jose Sanchez ; Daniel F. Schmidt ; Rita K. Schmutzler ; Melissa C. Southey ; Rulla Tamimi ; Ruth C. Travis ; Clare Turnbull ; Andre G. Uitterlinden ; Zhaoming Wang ; Alice S. Whittemore ; Xiaohong R. Yang ; Wei Zheng ; Thorunn Rafnar ; Julius Gudmundsson ; Simon N. Stacey ; Kari Stefansson ; Patrick Sulem ; Y. Ann Chen ; Jonathan P. Tyrer ; David C. Christiani ; Yongyue Wei ; Hongbing Shen ; Zhibin Hu ; Xiao-Ou Shu ; Kouya Shiraishi ; Atsushi Takahashi ; Yohan Bossé ; Ma N Obeidat ; David Nickle ; Wim Timens ; Matthew L. Freedman ; Qiyuan Li ; Daniela Seminara ; Stephen J. Chanock ; Jian Gong ; Ulrike Peters ; Stephen B. Gruber ; Christopher I. Amos ; Thomas A. Sellers ; Douglas F. Easton ; David J. Hunter ; Christopher A. Haiman ; Brian E. Henderson ; Rayjean J. HungSource :
- Cancer research [ 0008-5472 ] ; 2016.
Abstract
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with
Url:
DOI: 10.1158/0008-5472.CAN-15-2980
PubMed: 27197191
PubMed Central: 5010493
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name><affiliation><nlm:aff id="A7">University of Virginia, Charlottesville, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:aff id="A9">University of Göttingen, Medical School, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A16">University of Manchester, Manchester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27197191</idno><idno type="pmc">5010493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493</idno><idno type="RBID">PMC:5010493</idno><idno type="doi">10.1158/0008-5472.CAN-15-2980</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001F15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title><author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name><affiliation><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Eeles, Rosalind A" sort="Eeles, Rosalind A" uniqKey="Eeles R" first="Rosalind A." last="Eeles">Rosalind A. Eeles</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name><affiliation><nlm:aff id="A7">University of Virginia, Charlottesville, USA</nlm:aff></affiliation></author><author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation></author><author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name><affiliation><nlm:aff id="A9">University of Göttingen, Medical School, Göttingen, Germany</nlm:aff></affiliation></author><author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name><affiliation><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff></affiliation><affiliation><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name><affiliation><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name><affiliation><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name><affiliation><nlm:aff id="A16">University of Manchester, Manchester, UK</nlm:aff></affiliation><affiliation><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff></affiliation></author><author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff></affiliation></author><author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff></affiliation></author><author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name><affiliation><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff></affiliation></author><author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:aff id="A22">Service de Génétique Médicale, Nantes, France</nlm:aff></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:aff id="A23">Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name><affiliation><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name><affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff></affiliation></author><author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name><affiliation><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name><affiliation><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name><affiliation><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name><affiliation><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name><affiliation><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name><affiliation><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name><affiliation><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff></affiliation></author><author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name><affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff></affiliation></author><author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name><affiliation><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name><affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff></affiliation></author><author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name><affiliation><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff></affiliation></author><author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name><affiliation><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name><affiliation><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff></affiliation><affiliation><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name><affiliation><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name><affiliation><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff></affiliation><affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name><affiliation><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff></affiliation></author><author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name><affiliation><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff></affiliation></author><author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name><affiliation><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff></affiliation></author><author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name><affiliation><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff></affiliation></author><author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff></affiliation></author><author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name><affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff></affiliation></author><author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name><affiliation><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name><affiliation><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff></affiliation><affiliation><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff></affiliation></author><author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name><affiliation><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name><affiliation><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff></affiliation></author><author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name><affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name><affiliation><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff></affiliation></author><author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name><affiliation><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff></affiliation></author><author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name><affiliation><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name><affiliation><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff></affiliation></author><author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name><affiliation><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff></affiliation></author><author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name><affiliation><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff></affiliation></author><author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name><affiliation><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff></affiliation></author><author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name><affiliation><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff></affiliation></author><author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name><affiliation><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff></affiliation></author><author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name><affiliation><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff></affiliation></author><author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name><affiliation><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff></affiliation></author><author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name><affiliation><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff></affiliation></author><author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name><affiliation><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff></affiliation></author><author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name><affiliation><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff></affiliation></author><author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name><affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name><affiliation><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff></affiliation></author><author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name><affiliation><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff></affiliation></author><author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name><affiliation><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff></affiliation></author><author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name><affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff></affiliation></author><author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name><affiliation><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff></affiliation></author><author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name><affiliation><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="ISSN">0008-5472</idno><idno type="eISSN">1538-7445</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with <italic>ADAM15/THBS3</italic> gene expression in lung. We also identified a known breast cancer locus <italic>CASP8/ALS2CR12</italic> associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast <italic>BRCA2</italic> locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">2984705R</journal-id><journal-id journal-id-type="pubmed-jr-id">2786</journal-id><journal-id journal-id-type="nlm-ta">Cancer Res</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Res.</journal-id><journal-title-group><journal-title>Cancer research</journal-title></journal-title-group><issn pub-type="ppub">0008-5472</issn><issn pub-type="epub">1538-7445</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27197191</article-id><article-id pub-id-type="pmc">5010493</article-id><article-id pub-id-type="doi">10.1158/0008-5472.CAN-15-2980</article-id><article-id pub-id-type="manuscript">NIHMS780930</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fehringer</surname><given-names>Gordon</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kraft</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul D.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Eeles</surname><given-names>Rosalind A.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chatterjee</surname><given-names>Nilanjan</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schumacher</surname><given-names>Fred</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Schildkraut</surname><given-names>Joellen</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Lindström</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Brennan</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Bickeböller</surname><given-names>Heike</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Houlston</surname><given-names>Richard S.</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Landi</surname><given-names>Maria Teresa</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Caporaso</surname><given-names>Neil</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="A10">10</xref><xref ref-type="aff" rid="A11">11</xref><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Olama</surname><given-names>Ali Amin Al</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Berndt</surname><given-names>Sonja I</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Giovannucci</surname><given-names>Edward</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Grönberg</surname><given-names>Henrik</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Kote-Jarai</surname><given-names>Zsofia</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Muir</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Stampfer</surname><given-names>Meir</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Stevens</surname><given-names>Victoria L.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Wiklund</surname><given-names>Fredrik</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Willett</surname><given-names>Walter</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Goode</surname><given-names>Ellen L.</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Permuth</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Risch</surname><given-names>Harvey A.</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Reid</surname><given-names>Brett M.</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Bezieau</surname><given-names>Stephane</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Hermann</given-names></name><xref ref-type="aff" rid="A23">23</xref><xref ref-type="aff" rid="A24">24</xref><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Andrew T.</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Hudson</surname><given-names>Thomas J.</given-names></name><xref ref-type="aff" rid="A28">28</xref></contrib><contrib contrib-type="author"><name><surname>Kocarnik</surname><given-names>Jonathan K.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Newcomb</surname><given-names>Polly A.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Schoen</surname><given-names>Robert E.</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Slattery</surname><given-names>Martha L.</given-names></name><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>White</surname><given-names>Emily</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Adank</surname><given-names>Muriel A.</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Ahsan</surname><given-names>Habibul</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Aittomäki</surname><given-names>Kristiina</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Baglietto</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Blomquist</surname><given-names>Carl</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Canzian</surname><given-names>Federico</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Czene</surname><given-names>Kamila</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>dos-Santos-Silva</surname><given-names>Isabel</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Eliassen</surname><given-names>A. Heather</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>Jonine</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Flesch-Janys</surname><given-names>Dieter</given-names></name><xref ref-type="aff" rid="A38">38</xref></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>Olivia</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Garcia-Closas</surname><given-names>Montserrat</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gaudet</surname><given-names>Mia M.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Nichola</given-names></name><xref ref-type="aff" rid="A39">39</xref></contrib><contrib contrib-type="author"><name><surname>Hall</surname><given-names>Per</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Hazra</surname><given-names>Aditi</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Hein</surname><given-names>Rebecca</given-names></name><xref ref-type="aff" rid="A40">40</xref><xref ref-type="aff" rid="A41">41</xref></contrib><contrib contrib-type="author"><name><surname>Hofman</surname><given-names>Albert</given-names></name><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Hopper</surname><given-names>John L.</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Irwanto</surname><given-names>Astrid</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Johansson</surname><given-names>Mattias</given-names></name><xref ref-type="aff" rid="A8">8</xref><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Kaaks</surname><given-names>Rudolf</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Kibriya</surname><given-names>Muhammad G.</given-names></name><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Lichtner</surname><given-names>Peter</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jianjun</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Lund</surname><given-names>Eiliv</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Makalic</surname><given-names>Enes</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Meindl</surname><given-names>Alfons</given-names></name><xref ref-type="aff" rid="A48">48</xref></contrib><contrib contrib-type="author"><name><surname>Müller-Myhsok</surname><given-names>Bertram</given-names></name><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Muranen</surname><given-names>Taru A.</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Nevanlinna</surname><given-names>Heli</given-names></name><xref ref-type="aff" rid="A34">34</xref></contrib><contrib contrib-type="author"><name><surname>Peeters</surname><given-names>Petra H.</given-names></name><xref ref-type="aff" rid="A50">50</xref></contrib><contrib contrib-type="author"><name><surname>Peto</surname><given-names>Julian</given-names></name><xref ref-type="aff" rid="A37">37</xref></contrib><contrib contrib-type="author"><name><surname>Prentice</surname><given-names>Ross L.</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Rahman</surname><given-names>Nazneen</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Sanchez</surname><given-names>Maria Jose</given-names></name><xref ref-type="aff" rid="A52">52</xref><xref ref-type="aff" rid="A53">53</xref><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Daniel F.</given-names></name><xref ref-type="aff" rid="A43">43</xref></contrib><contrib contrib-type="author"><name><surname>Schmutzler</surname><given-names>Rita K.</given-names></name><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>Southey</surname><given-names>Melissa C.</given-names></name><xref ref-type="aff" rid="A35">35</xref></contrib><contrib contrib-type="author"><name><surname>Tamimi</surname><given-names>Rulla</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Travis</surname><given-names>Ruth C.</given-names></name><xref ref-type="aff" rid="A56">56</xref></contrib><contrib contrib-type="author"><name><surname>Turnbull</surname><given-names>Clare</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G.</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Zhaoming</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S.</given-names></name><xref ref-type="aff" rid="A57">57</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Xiaohong R.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Wei</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Rafnar</surname><given-names>Thorunn</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Gudmundsson</surname><given-names>Julius</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Stacey</surname><given-names>Simon N.</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Stefansson</surname><given-names>Kari</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Sulem</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="A60">60</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Y. Ann</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Tyrer</surname><given-names>Jonathan P.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Christiani</surname><given-names>David C.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wei</surname><given-names>Yongyue</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Hongbing</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Zhibin</given-names></name><xref ref-type="aff" rid="A61">61</xref></contrib><contrib contrib-type="author"><name><surname>Shu</surname><given-names>Xiao-Ou</given-names></name><xref ref-type="aff" rid="A59">59</xref></contrib><contrib contrib-type="author"><name><surname>Shiraishi</surname><given-names>Kouya</given-names></name><xref ref-type="aff" rid="A62">62</xref></contrib><contrib contrib-type="author"><name><surname>Takahashi</surname><given-names>Atsushi</given-names></name><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Bossé</surname><given-names>Yohan</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Obeidat</surname><given-names>Ma’en</given-names></name><xref ref-type="aff" rid="A65">65</xref></contrib><contrib contrib-type="author"><name><surname>Nickle</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Timens</surname><given-names>Wim</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>Matthew L.</given-names></name><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Qiyuan</given-names></name><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Seminara</surname><given-names>Daniela</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Chanock</surname><given-names>Stephen J.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Jian</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Peters</surname><given-names>Ulrike</given-names></name><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Gruber</surname><given-names>Stephen B.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Amos</surname><given-names>Christopher I.</given-names></name><xref ref-type="aff" rid="A70">70</xref></contrib><contrib contrib-type="author"><name><surname>Sellers</surname><given-names>Thomas A.</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Easton</surname><given-names>Douglas F.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hunter</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Haiman</surname><given-names>Christopher A.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Henderson</surname><given-names>Brian E.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Hung</surname><given-names>Rayjean J.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><on-behalf-of>on behalf of Ovarian Cancer Association Consortium (OCAC);</on-behalf-of><on-behalf-of>on behalf of The PRACTICAL Consortium; on behalf of Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); on behalf of Colorectal Transdisciplinary (CORECT) Study; on behalf of African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</aff><aff id="A2"><label>2</label>Harvard T.H. Chan School of Public Health, Boston MA</aff><aff id="A3"><label>3</label>University of Cambridge, Cambridge, UK</aff><aff id="A4"><label>4</label>Institute of Cancer Research, London, UK</aff><aff id="A5"><label>5</label>National Cancer Instititute, Bethesda, USA</aff><aff id="A6"><label>6</label>University of Southern California, Los Angeles, USA</aff><aff id="A7"><label>7</label>University of Virginia, Charlottesville, USA</aff><aff id="A8"><label>8</label>International Agency for Research on Cancer, Lyon, France</aff><aff id="A9"><label>9</label>University of Göttingen, Medical School, Göttingen, Germany</aff><aff id="A10"><label>10</label>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</aff><aff id="A11"><label>11</label>Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</aff><aff id="A12"><label>12</label>Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</aff><aff id="A13"><label>13</label>Cambridge University, Cambridge, United Kingdom</aff><aff id="A14"><label>14</label>Karolinska Institutet, Stockholm, Sweden</aff><aff id="A15"><label>15</label>Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</aff><aff id="A16"><label>16</label>University of Manchester, Manchester, UK</aff><aff id="A17"><label>17</label>The University of Warwick, Coventry, UK</aff><aff id="A18"><label>18</label>Epidemiology Research Program, American Cancer Society, Atlanta GA</aff><aff id="A19"><label>19</label>Mayo Clinic, Rochester Minnesota</aff><aff id="A20"><label>20</label>Moffitt Cancer Center, Tampa, USA</aff><aff id="A21"><label>21</label>Yale School of Public Health, New Haven, Connecticut, USA</aff><aff id="A22"><label>22</label>Service de Génétique Médicale, Nantes, France</aff><aff id="A23"><label>23</label>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A24"><label>24</label>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A25"><label>25</label>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A26"><label>26</label>Massachusetts General Hospital, Boston, USA</aff><aff id="A27"><label>27</label>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</aff><aff id="A28"><label>28</label>Ontario Institute for Cancer Research, Toronto Ontario</aff><aff id="A29"><label>29</label>Fred Hutchinson Cancer Research Center, Seattle, USA</aff><aff id="A30"><label>30</label>University of Pittsburgh Medical Center, Pittsburgh, USA</aff><aff id="A31"><label>31</label>University of Utah Health Sciences Center, Salt Lake City, Utah, USA</aff><aff id="A32"><label>32</label>VU University Medical Center, Amsterdam, The Netherlands</aff><aff id="A33"><label>33</label>University of Chicago, Chicago, IL, USA</aff><aff id="A34"><label>34</label>University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A35"><label>35</label>The University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A36"><label>36</label>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</aff><aff id="A37"><label>37</label>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</aff><aff id="A38"><label>38</label>University Medical Center Hamburg-Eppendorf, Hamburg Germany</aff><aff id="A39"><label>39</label>Breakthrough Research Centre, The Institute of Cancer Research, London, UK</aff><aff id="A40"><label>40</label>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</aff><aff id="A41"><label>41</label>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</aff><aff id="A42"><label>42</label>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="A43"><label>43</label>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</aff><aff id="A44"><label>44</label>Genome Institute of Singapore, Singapore</aff><aff id="A45"><label>45</label>Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</aff><aff id="A46"><label>46</label>German Research Center for Environmental Health, Neuherberg, Germany</aff><aff id="A47"><label>47</label>Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</aff><aff id="A48"><label>48</label>Technische Universität München, Munich, Germany</aff><aff id="A49"><label>49</label>Max Planck Institute of Psychiatry, Munich, Germany</aff><aff id="A50"><label>50</label>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</aff><aff id="A51"><label>51</label>Institute of Cancer Research, Sutton, U.K</aff><aff id="A52"><label>52</label>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</aff><aff id="A53"><label>53</label>Hospitales Universitarios de Granada/Universidad de Granada, Spain</aff><aff id="A54"><label>54</label>CIBER de Epidemiología y Salud Pública CIBERESP, Spain</aff><aff id="A55"><label>55</label>University of Cologne, Cologne, Germany</aff><aff id="A56"><label>56</label>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</aff><aff id="A57"><label>57</label>Stanford University, Stanford, CA, USA</aff><aff id="A58"><label>58</label>Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</aff><aff id="A59"><label>59</label>Vanderbilt University, Nashville, USA</aff><aff id="A60"><label>60</label>deCODE genetics, Amgen, Reykjavik, Iceland</aff><aff id="A61"><label>61</label>Nanjing Medical University School of Public Health, Nanjing, China</aff><aff id="A62"><label>62</label>Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</aff><aff id="A63"><label>63</label>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</aff><aff id="A64"><label>64</label>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</aff><aff id="A65"><label>65</label>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</aff><aff id="A66"><label>66</label>Merck & Co, MRL, Seattle, Washington, United States</aff><aff id="A67"><label>67</label>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</aff><aff id="A68"><label>68</label>Dana-Farber Cancer Institute, Boston, USA</aff><aff id="A69"><label>69</label>Xiamen University, Xiamen China</aff><aff id="A70"><label>70</label>Geisel School of Medicine, Dartmouth College, Lebanon</aff><author-notes><corresp id="FN1">Corresponding author: Rayjean J. Hung, Ph.D., M.S., Senior Investigator, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 60 Murray St. Rm L5-215, Box 18, Toronto ON M5T 3L9. Canada, <email>rayjean.hung@lunenfeld.ca</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>9</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>3</month><year>2017</year></pub-date><volume>76</volume><issue>17</issue><fpage>5103</fpage><lpage>5114</lpage><pmc-comment>elocation-id from pubmed: 10.1158/0008-5472.CAN-15-2980</pmc-comment>
<abstract><p id="P1">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with <italic>ADAM15/THBS3</italic> gene expression in lung. We also identified a known breast cancer locus <italic>CASP8/ALS2CR12</italic> associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast <italic>BRCA2</italic> locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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