Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy
Identifieur interne : 004844 ( Ncbi/Checkpoint ); précédent : 004843; suivant : 004845Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy
Auteurs : Pravat K. Mandal [Inde, Australie] ; Deepika Shukla [Inde] ; Varan Govind [États-Unis] ; Yves Boulard [France] ; Lars Ersland [Norvège]Source :
- Journal of Alzheimer's Disease [ 1387-2877 ] ; ????.
Abstract
Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in
Url:
DOI: 10.3233/JAD-170350
PubMed: 28527221
PubMed Central: 5523836
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in <italic>in vivo</italic>
MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in <italic>in vivo</italic>
MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.</p>
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