Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.
Identifieur interne : 001188 ( PubMed/Curation ); précédent : 001187; suivant : 001189Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.
Auteurs : Pravat K. Mandal [Inde] ; Deepika Shukla [Inde] ; Varan Govind [États-Unis] ; Yves Boulard [France] ; Lars Ersland [Norvège]Source :
- Journal of Alzheimer's disease : JAD [ 1875-8908 ] ; 2017.
Abstract
Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., "extended" and "folded". The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.
DOI: 10.3233/JAD-170350
PubMed: 28527221
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Mandal</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon</wicri:regionArea></affiliation></author><author><name sortKey="Shukla, Deepika" sort="Shukla, Deepika" uniqKey="Shukla D" first="Deepika" last="Shukla">Deepika Shukla</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon</wicri:regionArea></affiliation></author><author><name sortKey="Govind, Varan" sort="Govind, Varan" uniqKey="Govind V" first="Varan" last="Govind">Varan Govind</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Miller School of Medicine, University of Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Miller School of Medicine, University of Miami, FL</wicri:regionArea></affiliation></author><author><name sortKey="Boulard, Yves" sort="Boulard, Yves" uniqKey="Boulard Y" first="Yves" last="Boulard">Yves Boulard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology, Saclay Institute of Biology and Technology, CEA-Saclay, Gif-sur-Yvette Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology, Saclay Institute of Biology and Technology, CEA-Saclay, Gif-sur-Yvette Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Ersland, Lars" sort="Ersland, Lars" uniqKey="Ersland L" first="Lars" last="Ersland">Lars Ersland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28527221</idno><idno type="pmid">28527221</idno><idno type="doi">10.3233/JAD-170350</idno><idno type="wicri:Area/PubMed/Corpus">001198</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001198</idno><idno type="wicri:Area/PubMed/Curation">001188</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001188</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.</title><author><name sortKey="Mandal, Pravat K" sort="Mandal, Pravat K" uniqKey="Mandal P" first="Pravat K" last="Mandal">Pravat K. Mandal</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon</wicri:regionArea></affiliation></author><author><name sortKey="Shukla, Deepika" sort="Shukla, Deepika" uniqKey="Shukla D" first="Deepika" last="Shukla">Deepika Shukla</name><affiliation wicri:level="1"><nlm:affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon</wicri:regionArea></affiliation></author><author><name sortKey="Govind, Varan" sort="Govind, Varan" uniqKey="Govind V" first="Varan" last="Govind">Varan Govind</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Miller School of Medicine, University of Miami, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Miller School of Medicine, University of Miami, FL</wicri:regionArea></affiliation></author><author><name sortKey="Boulard, Yves" sort="Boulard, Yves" uniqKey="Boulard Y" first="Yves" last="Boulard">Yves Boulard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology, Saclay Institute of Biology and Technology, CEA-Saclay, Gif-sur-Yvette Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology, Saclay Institute of Biology and Technology, CEA-Saclay, Gif-sur-Yvette Cedex</wicri:regionArea></affiliation></author><author><name sortKey="Ersland, Lars" sort="Ersland, Lars" uniqKey="Ersland L" first="Lars" last="Ersland">Lars Ersland</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's disease : JAD</title><idno type="eISSN">1875-8908</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., "extended" and "folded". The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28527221</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>20</Day></DateCreated><DateRevised><Year>2017</Year><Month>08</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1875-8908</ISSN><JournalIssue CitedMedium="Internet"><Volume>59</Volume><Issue>2</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>Journal of Alzheimer's disease : JAD</Title><ISOAbbreviation>J. Alzheimers Dis.</ISOAbbreviation></Journal><ArticleTitle>Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy.</ArticleTitle><Pagination><MedlinePgn>537-541</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JAD-170350</ELocationID><Abstract><AbstractText>Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., "extended" and "folded". The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in in vivo MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in in vivo MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mandal</LastName><ForeName>Pravat K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shukla</LastName><ForeName>Deepika</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Govind</LastName><ForeName>Varan</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Radiology, Miller School of Medicine, University of Miami, FL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boulard</LastName><ForeName>Yves</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology, Saclay Institute of Biology and Technology, CEA-Saclay, Gif-sur-Yvette Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ersland</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS060874</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS094043</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Alzheimers Dis</MedlineTA><NlmUniqueID>9814863</NlmUniqueID><ISSNLinking>1387-2877</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Redox Rep. 2005;10(2):83-90</RefSource><PMID Version="1">15949128</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Free Radic Biol Med. 2007 Oct 15;43(8):1099-108</RefSource><PMID Version="1">17854705</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Inorg Biochem. 1999 Jun 15;75(2):117-21</RefSource><PMID Version="1">10450606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>NMR Biomed. 2015 Jul;28(7):923-4</RefSource><PMID Version="1">26094860</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>FEBS J. 2010 Dec;277(24):5086-96</RefSource><PMID Version="1">21078121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Chim Slov. 2013;60(1):61-9</RefSource><PMID Version="1">23841333</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Inorg Biochem. 2004 Jun;98(6):1151-9</RefSource><PMID Version="1">15149827</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2004 Jun;1019:346-9</RefSource><PMID Version="1">15247041</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>EMBO Rep. 2006 Mar;7(3):271-5</RefSource><PMID Version="1">16607396</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Pept Protein Res. 1987 May;29(5):638-46</RefSource><PMID Version="1">3610478</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Free Radic Res. 2008 Feb;42(2):162-70</RefSource><PMID Version="1">18297609</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Antioxid Redox Signal. 2000 Fall;2(3):413-20</RefSource><PMID Version="1">11229355</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Spectrochim Acta A Mol Biomol Spectrosc. 2015;149:505-15</RefSource><PMID Version="1">25978018</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Sci. 1998 Jun 11;158(1):24-9</RefSource><PMID Version="1">9667773</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>NMR Biomed. 2000 May;13(3):129-53</RefSource><PMID Version="1">10861994</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Dis Markers. 2006;22(1-2):83-93</RefSource><PMID Version="1">16410648</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antioxidant</Keyword><Keyword MajorTopicYN="N">brain</Keyword><Keyword MajorTopicYN="N">conformation</Keyword><Keyword MajorTopicYN="N">glutathione</Keyword><Keyword MajorTopicYN="N">magnetic resonance spectroscopy</Keyword><Keyword MajorTopicYN="N">molecular dynamics</Keyword><Keyword MajorTopicYN="N">nuclear magnetic resonance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28527221</ArticleId><ArticleId IdType="pii">JAD170350</ArticleId><ArticleId IdType="doi">10.3233/JAD-170350</ArticleId><ArticleId IdType="pmc">PMC5523836</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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