Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy
Identifieur interne : 002E13 ( Pmc/Checkpoint ); précédent : 002E12; suivant : 002E14Glutathione Conformations and Its Implications for in vivo Magnetic Resonance Spectroscopy
Auteurs : Pravat K. Mandal [Inde, Australie] ; Deepika Shukla [Inde] ; Varan Govind [États-Unis] ; Yves Boulard [France] ; Lars Ersland [Norvège]Source :
- Journal of Alzheimer's Disease [ 1387-2877 ] ; ????.
Abstract
Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in
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DOI: 10.3233/JAD-170350
PubMed: 28527221
PubMed Central: 5523836
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Mandal</name><affiliation wicri:level="1"><nlm:aff id="aff1">Neuroimaging and Neurospectroscopy Laboratory,<institution>National Brain Research Center</institution>, Gurgaon,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Florey Institute of Neuroscience and Mental Health</institution>, Melbourne, VIC,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shukla, Deepika" sort="Shukla, Deepika" uniqKey="Shukla D" first="Deepika" last="Shukla">Deepika Shukla</name><affiliation wicri:level="1"><nlm:aff id="aff1">Neuroimaging and Neurospectroscopy Laboratory,<institution>National Brain Research Center</institution>, Gurgaon,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Govind, Varan" sort="Govind, Varan" uniqKey="Govind V" first="Varan" last="Govind">Varan Govind</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Radiology, Miller School of Medicine,<institution>University of Miami</institution>, FL,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boulard, Yves" sort="Boulard, Yves" uniqKey="Boulard Y" first="Yves" last="Boulard">Yves Boulard</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology,<institution>Saclay Institute of Biology and Technology</institution>, CEA-Saclay, Gif-sur-Yvette Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ersland, Lars" sort="Ersland, Lars" uniqKey="Ersland L" first="Lars" last="Ersland">Lars Ersland</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT – Norwegian Center for Mental Disorders Research,<institution>University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Alzheimer's Disease</title><idno type="ISSN">1387-2877</idno><idno type="eISSN">1875-8908</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in <italic>in vivo</italic> MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in <italic>in vivo</italic> MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Alzheimers Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Alzheimers Dis</journal-id><journal-id journal-id-type="publisher-id">JAD</journal-id><journal-title-group><journal-title>Journal of Alzheimer's Disease</journal-title></journal-title-group><issn pub-type="ppub">1387-2877</issn><issn pub-type="epub">1875-8908</issn><issn-l>1387-2877</issn-l><publisher><publisher-name>IOS Press</publisher-name><publisher-loc>Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28527221</article-id><article-id pub-id-type="pmc">5523836</article-id><article-id pub-id-type="publisher-id">JAD170350</article-id><article-id pub-id-type="doi">10.3233/JAD-170350</article-id><article-categories><subj-group subj-group-type="heading"><subject>Hypothesis</subject></subj-group></article-categories><title-group><article-title>Glutathione Conformations and Its Implications for <italic>in vivo</italic> Magnetic Resonance Spectroscopy</article-title><alt-title alt-title-type="left-running-head">P.K. Mandal et al.</alt-title><alt-title alt-title-type="right-running-head">Glutathione Conformations and <italic>in vivo</italic> MRS</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mandal</surname><given-names>Pravat K.</given-names></name><xref ref-type="aff" rid="aff1">a</xref><xref ref-type="aff" rid="aff2">b</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Shukla</surname><given-names>Deepika</given-names></name><xref ref-type="aff" rid="aff1">a</xref></contrib><contrib contrib-type="author"><name><surname>Govind</surname><given-names>Varan</given-names></name><xref ref-type="aff" rid="aff3">c</xref></contrib><contrib contrib-type="author"><name><surname>Boulard</surname><given-names>Yves</given-names></name><xref ref-type="aff" rid="aff4">d</xref></contrib><contrib contrib-type="author"><name><surname>Ersland</surname><given-names>Lars</given-names></name><xref ref-type="aff" rid="aff5">e</xref></contrib><aff id="aff1"><label>a</label>Neuroimaging and Neurospectroscopy Laboratory,<institution>National Brain Research Center</institution>, Gurgaon,<country>India</country></aff><aff id="aff2"><label>b</label><institution>The Florey Institute of Neuroscience and Mental Health</institution>, Melbourne, VIC,<country>Australia</country></aff><aff id="aff3"><label>c</label>Department of Radiology, Miller School of Medicine,<institution>University of Miami</institution>, FL,<country>USA</country></aff><aff id="aff4"><label>d</label>Department of Integrated Biology and Molecular Genetics, Laboratory of Integrated Biology,<institution>Saclay Institute of Biology and Technology</institution>, CEA-Saclay, Gif-sur-Yvette Cedex,<country>France</country></aff><aff id="aff5"><label>e</label>Department of Clinical Engineering, Haukeland University Hospital, Department of Biological and Medical Psychology, University of Bergen, NORMENT – Norwegian Center for Mental Disorders Research,<institution>University of Bergen</institution>, Bergen,<country>Norway</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Dr. Pravat K. Mandal, Professor, Neuroimaging and Neurospectroscopy Laboratory, National Brain Research Center, Gurgaon, India. Tel.: +91 9910318922; E-mails: <email>pravat.mandal@gmail.com</email>; <email>pravat@nbrc.ac.in</email>.</corresp></author-notes><pub-date date-type="preprint" publication-format="electronic"><day>17</day><month>5</month><year>2017</year></pub-date><pub-date date-type="pub" publication-format="electronic"><day>17</day><month>7</month><year>2017</year></pub-date><pub-date date-type="collection" publication-format="electronic"><year>2017</year></pub-date><volume>59</volume><issue>2</issue><fpage>537</fpage><lpage>541</lpage><history><date date-type="accepted"><day>10</day><month>5</month><year>2017</year></date></history><permissions><copyright-statement>© 2017 – IOS Press and the authors. All rights reserved</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by-nc/4.0/" license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License</ext-link>, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Glutathione (GSH) is a major antioxidant in humans that is involved in the detoxification of reactive radicals and peroxides. The molecular structural conformations of GSH depend on the surrounding micro-environment, and it has been experimentally evaluated using NMR and Raman spectroscopic techniques as well as by molecular dynamics simulation studies. The converging report indicates that GSH exists mainly in two major conformations, i.e., “extended” and “folded”. The NMR-derived information on the GSH conformers is essential to obtain optimal acquisition parameters in <italic>in vivo</italic> MRS experiments targeted for GSH detection. To further investigate the implications of GSH conformers in <italic>in vivo</italic> MRS studies and their relative proportions in healthy and pathological conditions, a multi-center clinical research study is necessary with a common protocol for GSH detection and quantification.</p></abstract><kwd-group><label>Keywords</label><kwd>Antioxidant</kwd><kwd>brain</kwd><kwd>conformation</kwd><kwd>glutathione</kwd><kwd>magnetic resonance spectroscopy</kwd><kwd>molecular dynamics</kwd><kwd>nuclear magnetic resonance</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Australie</li><li>France</li><li>Inde</li><li>Norvège</li><li>États-Unis</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Mandal, Pravat K" sort="Mandal, Pravat K" uniqKey="Mandal P" first="Pravat K." last="Mandal">Pravat K. Mandal</name></noRegion><name sortKey="Shukla, Deepika" sort="Shukla, Deepika" uniqKey="Shukla D" first="Deepika" last="Shukla">Deepika Shukla</name></country><country name="Australie"><noRegion><name sortKey="Mandal, Pravat K" sort="Mandal, Pravat K" uniqKey="Mandal P" first="Pravat K." last="Mandal">Pravat K. Mandal</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Govind, Varan" sort="Govind, Varan" uniqKey="Govind V" first="Varan" last="Govind">Varan Govind</name></noRegion></country><country name="France"><noRegion><name sortKey="Boulard, Yves" sort="Boulard, Yves" uniqKey="Boulard Y" first="Yves" last="Boulard">Yves Boulard</name></noRegion></country><country name="Norvège"><noRegion><name sortKey="Ersland, Lars" sort="Ersland, Lars" uniqKey="Ersland L" first="Lars" last="Ersland">Lars Ersland</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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