Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Identifieur interne : 007082 ( Main/Curation ); précédent : 007081; suivant : 007083Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Auteurs : H. G. Mar Fan [Canada, Australie] ; N. Houédé-Tchen [Canada, France] ; I. Chemerynsky [Canada] ; Q.-L. Yi [Canada] ; W. Xu [Canada] ; B. Harvey [Canada] ; I. F. Tannock [Canada]Source :
- Annals of Oncology [ 0923-7534 ] ; 2010-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte, Femme, Homme, Prospective.
English descriptors
- KwdEn :
Abstract
Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.
Url:
DOI: 10.1093/annonc/mdp394
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002657
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :002657
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000989
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007616
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002649
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :003937
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002272
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :007D40
Links to Exploration step
ISTEX:CEB5D91EC219FA79B882A73687C17E1E14B61864Curation
No country items
I. F. Tannock<affiliation><wicri:noCountry code="syntax">???</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houédé-Tchen">N. Houédé-Tchen</name>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CEB5D91EC219FA79B882A73687C17E1E14B61864</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1093/annonc/mdp394</idno>
<idno type="url">https://api.istex.fr/document/CEB5D91EC219FA79B882A73687C17E1E14B61864/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002657</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002657</idno>
<idno type="wicri:Area/Istex/Curation">002657</idno>
<idno type="wicri:Area/Istex/Checkpoint">000989</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000989</idno>
<idno type="wicri:doubleKey">0923-7534:2010:Mar Fan H:menopausal:symptoms:in</idno>
<idno type="wicri:Area/Main/Merge">007616</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0265852</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002649</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003937</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002272</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002272</idno>
<idno type="wicri:doubleKey">0923-7534:2010:Mar Fan H:menopausal:symptoms:in</idno>
<idno type="wicri:Area/Main/Merge">007D40</idno>
<idno type="wicri:Area/Main/Curation">007082</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Oncology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houédé-Tchen">N. Houédé-Tchen</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biostatistics, Canadian Blood Services, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
<affiliation><wicri:noCountry code="syntax">???</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Oncology</title>
<idno type="ISSN">0923-7534</idno>
<idno type="eISSN">1569-8041</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2010-05">2010-05</date>
<biblScope unit="volume">21</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="983">983</biblScope>
<biblScope unit="page" to="987">987</biblScope>
</imprint>
<idno type="ISSN">0923-7534</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0923-7534</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Breast cancer</term>
<term>Chemotherapy</term>
<term>Fatigue</term>
<term>Female</term>
<term>Human</term>
<term>Menopause</term>
<term>Prospective</term>
<term>Quality of life</term>
<term>Symptomatology</term>
<term>Woman</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Cancer du sein</term>
<term>Chimiothérapie</term>
<term>Fatigue</term>
<term>Femelle</term>
<term>Femme</term>
<term>Homme</term>
<term>Ménopause</term>
<term>Prospective</term>
<term>Qualité de vie</term>
<term>Symptomatologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Femme</term>
<term>Homme</term>
<term>Prospective</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div>
</front>
</TEI>
<double idat="0923-7534:2010:Mar Fan H:menopausal:symptoms:in"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Princess Alexandra Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houede-Tchen">N. Houede-Tchen</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Medical Oncology, Institut Bergonié</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Canadian Blood Services</s1>
<s2>Ottawa, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Ottawa, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Family and Community Medicine, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0265852</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0265852 INIST</idno>
<idno type="RBID">Pascal:10-0265852</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002649</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003937</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002272</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002272</idno>
<idno type="wicri:doubleKey">0923-7534:2010:Mar Fan H:menopausal:symptoms:in</idno>
<idno type="wicri:Area/Main/Merge">007D40</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medical Oncology, Princess Alexandra Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Brisbane, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houede-Tchen">N. Houede-Tchen</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Medical Oncology, Institut Bergonié</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Biostatistics, Canadian Blood Services</s1>
<s2>Ottawa, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Ottawa, Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Family and Community Medicine, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of oncology</title>
<title level="j" type="abbreviated">Ann. oncol.</title>
<idno type="ISSN">0923-7534</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of oncology</title>
<title level="j" type="abbreviated">Ann. oncol.</title>
<idno type="ISSN">0923-7534</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Breast cancer</term>
<term>Chemotherapy</term>
<term>Fatigue</term>
<term>Female</term>
<term>Human</term>
<term>Menopause</term>
<term>Prospective</term>
<term>Quality of life</term>
<term>Symptomatology</term>
<term>Woman</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ménopause</term>
<term>Symptomatologie</term>
<term>Homme</term>
<term>Femelle</term>
<term>Adulte</term>
<term>Femme</term>
<term>Chimiothérapie</term>
<term>Prospective</term>
<term>Cancer du sein</term>
<term>Fatigue</term>
<term>Qualité de vie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
<term>Adulte</term>
<term>Femme</term>
<term>Prospective</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houédé-Tchen">N. Houédé-Tchen</name>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:CEB5D91EC219FA79B882A73687C17E1E14B61864</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1093/annonc/mdp394</idno>
<idno type="url">https://api.istex.fr/document/CEB5D91EC219FA79B882A73687C17E1E14B61864/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002657</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002657</idno>
<idno type="wicri:Area/Istex/Curation">002657</idno>
<idno type="wicri:Area/Istex/Checkpoint">000989</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000989</idno>
<idno type="wicri:doubleKey">0923-7534:2010:Mar Fan H:menopausal:symptoms:in</idno>
<idno type="wicri:Area/Main/Merge">007616</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</title>
<author><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Medical Oncology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Houede Tchen, N" sort="Houede Tchen, N" uniqKey="Houede Tchen N" first="N." last="Houédé-Tchen">N. Houédé-Tchen</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Oncology, Institut Bergonié, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yi, Q L" sort="Yi, Q L" uniqKey="Yi Q" first="Q.-L." last="Yi">Q.-L. Yi</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biostatistics, Canadian Blood Services, Ottawa, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, W" sort="Xu, W" uniqKey="Xu W" first="W." last="Xu">W. Xu</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. Harvey</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Family and Community Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I. F." last="Tannock">I. F. Tannock</name>
<affiliation wicri:level="4"><country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
<affiliation><wicri:noCountry code="syntax">???</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Canada</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Oncology</title>
<idno type="ISSN">0923-7534</idno>
<idno type="eISSN">1569-8041</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2010-05">2010-05</date>
<biblScope unit="volume">21</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="983">983</biblScope>
<biblScope unit="page" to="987">987</biblScope>
</imprint>
<idno type="ISSN">0923-7534</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0923-7534</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div>
</front>
</TEI>
</ISTEX>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007082 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 007082 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Curation |type= RBID |clé= ISTEX:CEB5D91EC219FA79B882A73687C17E1E14B61864 |texte= Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study }}
This area was generated with Dilib version V0.6.33. |