Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Identifieur interne : 000989 ( Istex/Checkpoint ); précédent : 000988; suivant : 000990Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Auteurs : H. G. Mar Fan [Canada, Australie] ; N. Houédé-Tchen [Canada, France] ; I. Chemerynsky [Canada] ; Q.-L. Yi [Canada] ; W. Xu [Canada] ; B. Harvey [Canada] ; I. F. Tannock [Canada]Source :
- Annals of Oncology [ 0923-7534 ] ; 2010-05.
Abstract
Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51% versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.
Url:
DOI: 10.1093/annonc/mdp394
Affiliations:
- Australie, Canada, France
- Aquitaine, Nouvelle-Aquitaine, Ontario
- Bordeaux, Toronto
- Université de Toronto
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There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Ontario</li></region><settlement><li>Bordeaux</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><region name="Ontario"><name sortKey="Mar Fan, H G" sort="Mar Fan, H G" uniqKey="Mar Fan H" first="H. G." last="Mar Fan">H. G. Mar Fan</name></region><name sortKey="Chemerynsky, I" sort="Chemerynsky, I" uniqKey="Chemerynsky I" first="I." last="Chemerynsky">I. Chemerynsky</name><name sortKey="Harvey, B" sort="Harvey, B" uniqKey="Harvey B" first="B." last="Harvey">B. 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