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Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study

Identifieur interne : 002649 ( PascalFrancis/Corpus ); précédent : 002648; suivant : 002650

Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study

Auteurs : H. G. Mar Fan ; N. Houede-Tchen ; I. Chemerynsky ; Q.-L. Yi ; W. Xu ; B. Harvey ; I. F. Tannock

Source :

RBID : Pascal:10-0265852

Descripteurs français

English descriptors

Abstract

Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0923-7534
A03   1    @0 Ann. oncol.
A05       @2 21
A06       @2 5
A08 01  1  ENG  @1 Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
A11 01  1    @1 MAR FAN (H. G.)
A11 02  1    @1 HOUEDE-TCHEN (N.)
A11 03  1    @1 CHEMERYNSKY (I.)
A11 04  1    @1 YI (Q.-L.)
A11 05  1    @1 XU (W.)
A11 06  1    @1 HARVEY (B.)
A11 07  1    @1 TANNOCK (I. F.)
A14 01      @1 Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut.
A14 02      @1 Department of Medical Oncology, Princess Alexandra Hospital @2 Brisbane, Queensland @3 AUS @Z 1 aut.
A14 03      @1 Department of Medical Oncology, Institut Bergonié @2 Bordeaux @3 FRA @Z 2 aut.
A14 04      @1 Department of Biostatistics, Canadian Blood Services @2 Ottawa, Ontario @3 CAN @Z 4 aut.
A14 05      @1 Department of Family and Community Medicine, University of Toronto @2 Toronto, Ontario @3 CAN @Z 6 aut.
A20       @1 983-987
A21       @1 2010
A23 01      @0 ENG
A43 01      @1 INIST @2 22429 @5 354000181132910130
A44       @0 0000 @1 © 2010 INIST-CNRS. All rights reserved.
A45       @0 18 ref.
A47 01  1    @0 10-0265852
A60       @1 P
A61       @0 A
A64 01  1    @0 Annals of oncology
A66 01      @0 GBR
C01 01    ENG  @0 Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.
C02 01  X    @0 002B02R
C02 02  X    @0 002B20E02
C03 01  X  FRE  @0 Ménopause @5 01
C03 01  X  ENG  @0 Menopause @5 01
C03 01  X  SPA  @0 Menopausia @5 01
C03 02  X  FRE  @0 Symptomatologie @5 02
C03 02  X  ENG  @0 Symptomatology @5 02
C03 02  X  SPA  @0 Sintomatología @5 02
C03 03  X  FRE  @0 Homme @5 03
C03 03  X  ENG  @0 Human @5 03
C03 03  X  SPA  @0 Hombre @5 03
C03 04  X  FRE  @0 Femelle @5 04
C03 04  X  ENG  @0 Female @5 04
C03 04  X  SPA  @0 Hembra @5 04
C03 05  X  FRE  @0 Adulte @5 05
C03 05  X  ENG  @0 Adult @5 05
C03 05  X  SPA  @0 Adulto @5 05
C03 06  X  FRE  @0 Femme @5 06
C03 06  X  ENG  @0 Woman @5 06
C03 06  X  SPA  @0 Mujer @5 06
C03 07  X  FRE  @0 Chimiothérapie @5 07
C03 07  X  ENG  @0 Chemotherapy @5 07
C03 07  X  SPA  @0 Quimioterapia @5 07
C03 08  X  FRE  @0 Prospective @5 09
C03 08  X  ENG  @0 Prospective @5 09
C03 08  X  SPA  @0 Prospectiva @5 09
C03 09  X  FRE  @0 Cancer du sein @2 NM @5 10
C03 09  X  ENG  @0 Breast cancer @2 NM @5 10
C03 09  X  SPA  @0 Cáncer del pecho @2 NM @5 10
C03 10  X  FRE  @0 Fatigue @5 11
C03 10  X  ENG  @0 Fatigue @5 11
C03 10  X  SPA  @0 Fatiga @5 11
C03 11  X  FRE  @0 Qualité de vie @5 12
C03 11  X  ENG  @0 Quality of life @5 12
C03 11  X  SPA  @0 Calidad vida @5 12
C07 01  X  FRE  @0 Traitement
C07 01  X  ENG  @0 Treatment
C07 01  X  SPA  @0 Tratamiento
C07 02  X  FRE  @0 Tumeur maligne @2 NM @5 37
C07 02  X  ENG  @0 Malignant tumor @2 NM @5 37
C07 02  X  SPA  @0 Tumor maligno @2 NM @5 37
C07 03  X  FRE  @0 Cancer @2 NM
C07 03  X  ENG  @0 Cancer @2 NM
C07 03  X  SPA  @0 Cáncer @2 NM
C07 04  X  FRE  @0 Pathologie de la glande mammaire @2 NM @5 38
C07 04  X  ENG  @0 Mammary gland diseases @2 NM @5 38
C07 04  X  SPA  @0 Glándula mamaria patología @2 NM @5 38
C07 05  X  FRE  @0 Pathologie du sein @2 NM @5 39
C07 05  X  ENG  @0 Breast disease @2 NM @5 39
C07 05  X  SPA  @0 Seno patología @2 NM @5 39
N21       @1 172
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 10-0265852 INIST
ET : Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
AU : MAR FAN (H. G.); HOUEDE-TCHEN (N.); CHEMERYNSKY (I.); YI (Q.-L.); XU (W.); HARVEY (B.); TANNOCK (I. F.)
AF : Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Department of Medical Oncology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (1 aut.); Department of Medical Oncology, Institut Bergonié/Bordeaux/France (2 aut.); Department of Biostatistics, Canadian Blood Services/Ottawa, Ontario/Canada (4 aut.); Department of Family and Community Medicine, University of Toronto/Toronto, Ontario/Canada (6 aut.)
DT : Publication en série; Niveau analytique
SO : Annals of oncology; ISSN 0923-7534; Royaume-Uni; Da. 2010; Vol. 21; No. 5; Pp. 983-987; Bibl. 18 ref.
LA : Anglais
EA : Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.
CC : 002B02R; 002B20E02
FD : Ménopause; Symptomatologie; Homme; Femelle; Adulte; Femme; Chimiothérapie; Prospective; Cancer du sein; Fatigue; Qualité de vie
FG : Traitement; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein
ED : Menopause; Symptomatology; Human; Female; Adult; Woman; Chemotherapy; Prospective; Breast cancer; Fatigue; Quality of life
EG : Treatment; Malignant tumor; Cancer; Mammary gland diseases; Breast disease
SD : Menopausia; Sintomatología; Hombre; Hembra; Adulto; Mujer; Quimioterapia; Prospectiva; Cáncer del pecho; Fatiga; Calidad vida
LO : INIST-22429.354000181132910130
ID : 10-0265852

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Pascal:10-0265852

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<term>Ménopause</term>
<term>Symptomatologie</term>
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<term>Femme</term>
<term>Chimiothérapie</term>
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<div type="abstract" xml:lang="en">Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div>
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<s1>Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>MAR FAN (H. G.)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>HOUEDE-TCHEN (N.)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>CHEMERYNSKY (I.)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>YI (Q.-L.)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>XU (W.)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>HARVEY (B.)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>TANNOCK (I. F.)</s1>
</fA11>
<fA14 i1="01">
<s1>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Department of Medical Oncology, Princess Alexandra Hospital</s1>
<s2>Brisbane, Queensland</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Department of Medical Oncology, Institut Bergonié</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Department of Biostatistics, Canadian Blood Services</s1>
<s2>Ottawa, Ontario</s2>
<s3>CAN</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05">
<s1>Department of Family and Community Medicine, University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20>
<s1>983-987</s1>
</fA20>
<fA21>
<s1>2010</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>22429</s2>
<s5>354000181132910130</s5>
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<fA44>
<s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>18 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>10-0265852</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Annals of oncology</s0>
</fA64>
<fA66 i1="01">
<s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B02R</s0>
</fC02>
<fC02 i1="02" i2="X">
<s0>002B20E02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Ménopause</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Menopause</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Menopausia</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Symptomatologie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Symptomatology</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Sintomatología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Homme</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Human</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Femelle</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Female</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Hembra</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Adulte</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Adult</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Adulto</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Femme</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Woman</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Mujer</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Chimiothérapie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Chemotherapy</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Quimioterapia</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Prospective</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Prospective</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Prospectiva</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Cancer du sein</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Breast cancer</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Cáncer del pecho</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Fatigue</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Fatigue</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Fatiga</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Qualité de vie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Quality of life</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Calidad vida</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Traitement</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Treatment</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Tratamiento</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie de la glande mammaire</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Mammary gland diseases</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Glándula mamaria patología</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Pathologie du sein</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Breast disease</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Seno patología</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fN21>
<s1>172</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
<server>
<NO>PASCAL 10-0265852 INIST</NO>
<ET>Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</ET>
<AU>MAR FAN (H. G.); HOUEDE-TCHEN (N.); CHEMERYNSKY (I.); YI (Q.-L.); XU (W.); HARVEY (B.); TANNOCK (I. F.)</AU>
<AF>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Department of Medical Oncology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (1 aut.); Department of Medical Oncology, Institut Bergonié/Bordeaux/France (2 aut.); Department of Biostatistics, Canadian Blood Services/Ottawa, Ontario/Canada (4 aut.); Department of Family and Community Medicine, University of Toronto/Toronto, Ontario/Canada (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Annals of oncology; ISSN 0923-7534; Royaume-Uni; Da. 2010; Vol. 21; No. 5; Pp. 983-987; Bibl. 18 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</EA>
<CC>002B02R; 002B20E02</CC>
<FD>Ménopause; Symptomatologie; Homme; Femelle; Adulte; Femme; Chimiothérapie; Prospective; Cancer du sein; Fatigue; Qualité de vie</FD>
<FG>Traitement; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein</FG>
<ED>Menopause; Symptomatology; Human; Female; Adult; Woman; Chemotherapy; Prospective; Breast cancer; Fatigue; Quality of life</ED>
<EG>Treatment; Malignant tumor; Cancer; Mammary gland diseases; Breast disease</EG>
<SD>Menopausia; Sintomatología; Hombre; Hembra; Adulto; Mujer; Quimioterapia; Prospectiva; Cáncer del pecho; Fatiga; Calidad vida</SD>
<LO>INIST-22429.354000181132910130</LO>
<ID>10-0265852</ID>
</server>
</inist>
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