Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Identifieur interne : 002649 ( PascalFrancis/Corpus ); précédent : 002648; suivant : 002650Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study
Auteurs : H. G. Mar Fan ; N. Houede-Tchen ; I. Chemerynsky ; Q.-L. Yi ; W. Xu ; B. Harvey ; I. F. TannockSource :
- Annals of oncology [ 0923-7534 ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.
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Format Inist (serveur)
NO : | PASCAL 10-0265852 INIST |
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ET : | Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study |
AU : | MAR FAN (H. G.); HOUEDE-TCHEN (N.); CHEMERYNSKY (I.); YI (Q.-L.); XU (W.); HARVEY (B.); TANNOCK (I. F.) |
AF : | Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Department of Medical Oncology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (1 aut.); Department of Medical Oncology, Institut Bergonié/Bordeaux/France (2 aut.); Department of Biostatistics, Canadian Blood Services/Ottawa, Ontario/Canada (4 aut.); Department of Family and Community Medicine, University of Toronto/Toronto, Ontario/Canada (6 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Annals of oncology; ISSN 0923-7534; Royaume-Uni; Da. 2010; Vol. 21; No. 5; Pp. 983-987; Bibl. 18 ref. |
LA : | Anglais |
EA : | Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause. |
CC : | 002B02R; 002B20E02 |
FD : | Ménopause; Symptomatologie; Homme; Femelle; Adulte; Femme; Chimiothérapie; Prospective; Cancer du sein; Fatigue; Qualité de vie |
FG : | Traitement; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein |
ED : | Menopause; Symptomatology; Human; Female; Adult; Woman; Chemotherapy; Prospective; Breast cancer; Fatigue; Quality of life |
EG : | Treatment; Malignant tumor; Cancer; Mammary gland diseases; Breast disease |
SD : | Menopausia; Sintomatología; Hombre; Hembra; Adulto; Mujer; Quimioterapia; Prospectiva; Cáncer del pecho; Fatiga; Calidad vida |
LO : | INIST-22429.354000181132910130 |
ID : | 10-0265852 |
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<term>Human</term>
<term>Menopause</term>
<term>Prospective</term>
<term>Quality of life</term>
<term>Symptomatology</term>
<term>Woman</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Ménopause</term>
<term>Symptomatologie</term>
<term>Homme</term>
<term>Femelle</term>
<term>Adulte</term>
<term>Femme</term>
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<front><div type="abstract" xml:lang="en">Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</div>
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<fA14 i1="02"><s1>Department of Medical Oncology, Princess Alexandra Hospital</s1>
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<fA14 i1="03"><s1>Department of Medical Oncology, Institut Bergonié</s1>
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<fA14 i1="04"><s1>Department of Biostatistics, Canadian Blood Services</s1>
<s2>Ottawa, Ontario</s2>
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<fC01 i1="01" l="ENG"><s0>Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</s0>
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<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Prospective</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Prospective</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Prospectiva</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Cancer du sein</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Breast cancer</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Cáncer del pecho</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Fatigue</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Fatigue</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Fatiga</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Qualité de vie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Quality of life</s0>
<s5>12</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Calidad vida</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Traitement</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Treatment</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Tratamiento</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s2>NM</s2>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cancer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Cáncer</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de la glande mammaire</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammary gland diseases</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Glándula mamaria patología</s0>
<s2>NM</s2>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du sein</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Breast disease</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Seno patología</s0>
<s2>NM</s2>
<s5>39</s5>
</fC07>
<fN21><s1>172</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 10-0265852 INIST</NO>
<ET>Menopausal symptoms in women undergoing chemotherapy-induced and natural menopause: a prospective controlled study</ET>
<AU>MAR FAN (H. G.); HOUEDE-TCHEN (N.); CHEMERYNSKY (I.); YI (Q.-L.); XU (W.); HARVEY (B.); TANNOCK (I. F.)</AU>
<AF>Division of Medical Oncology and Hematology, Princess Margaret Hospital and University of Toronto/Toronto, Ontario/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut.); Department of Medical Oncology, Princess Alexandra Hospital/Brisbane, Queensland/Australie (1 aut.); Department of Medical Oncology, Institut Bergonié/Bordeaux/France (2 aut.); Department of Biostatistics, Canadian Blood Services/Ottawa, Ontario/Canada (4 aut.); Department of Family and Community Medicine, University of Toronto/Toronto, Ontario/Canada (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Annals of oncology; ISSN 0923-7534; Royaume-Uni; Da. 2010; Vol. 21; No. 5; Pp. 983-987; Bibl. 18 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Women with breast cancer frequently undergo menopause following adjuvant chemotherapy. Here, we investigated whether they have more severe symptoms than women undergoing natural menopause. Patients and methods: Forty-one women who had undergone menopause as a result of chemotherapy and 57 healthy women who had undergone recent natural menopause were evaluated on two occasions 1 year apart. The primary end point was the summed score of the self-report Functional Assessment of Cancer Therapy, endocrine symptoms (FACT-ES) scale. Quality of life was evaluated by the FACT-G questionnaire and fatigue by the FACT-F subscale. Results: There was a strong trend for patients to report worse FACT-ES scores than controls at the first (P = 0.05) and second (P = 0.04) time points. More patients had moderate/severe hot flashes than controls undergoing natural menopause (51 % versus 19%, P = 0.003). Patients reported worse fatigue than controls at the first assessment (P = 0.04), with no difference at the second. Menopausal symptoms were associated with fatigue for both groups. There was no difference between patients and controls in the quality-of-life scale, although assessment of patients is likely subject to adaptation and response-shift bias. Conclusions: Women undergoing chemotherapy-induced menopause may experience worse symptoms than women undergoing natural menopause.</EA>
<CC>002B02R; 002B20E02</CC>
<FD>Ménopause; Symptomatologie; Homme; Femelle; Adulte; Femme; Chimiothérapie; Prospective; Cancer du sein; Fatigue; Qualité de vie</FD>
<FG>Traitement; Tumeur maligne; Cancer; Pathologie de la glande mammaire; Pathologie du sein</FG>
<ED>Menopause; Symptomatology; Human; Female; Adult; Woman; Chemotherapy; Prospective; Breast cancer; Fatigue; Quality of life</ED>
<EG>Treatment; Malignant tumor; Cancer; Mammary gland diseases; Breast disease</EG>
<SD>Menopausia; Sintomatología; Hombre; Hembra; Adulto; Mujer; Quimioterapia; Prospectiva; Cáncer del pecho; Fatiga; Calidad vida</SD>
<LO>INIST-22429.354000181132910130</LO>
<ID>10-0265852</ID>
</server>
</inist>
</record>
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