Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.
Identifieur interne : 002F77 ( Main/Curation ); précédent : 002F76; suivant : 002F78Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.
Auteurs : Anika Reuter [Allemagne] ; Scott E. Panozza [Australie] ; Christophe Macri [Australie] ; Claire Dumont [Australie] ; Jessica Li [Australie] ; Haiyin Liu [Australie] ; Elodie Segura [France] ; Javier Vega-Ramos [Australie] ; Nishma Gupta [Australie] ; Irina Caminschi [Australie] ; Jose A. Villadangos [Australie] ; Angus P R. Johnston [Australie] ; Justine D. Mintern [Australie]Source :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Anticorps (immunologie), Antigènes CD (immunologie), Antigènes CD (métabolisme), Antigènes CD11b (immunologie), Antigènes CD11c (immunologie), Antigènes CD40 (immunologie), Antigènes d'histocompatibilité de classe I (immunologie), Antigènes d'histocompatibilité de classe II (immunologie), Antigènes mineurs d'histocompatibilité, Cellules cultivées, Cellules dendritiques (immunologie), Cellules dendritiques (métabolisme), Endocytose (immunologie), Humains, Lectines de type C (immunologie), Présentation d'antigène (immunologie), Récepteurs de surface cellulaire (immunologie), Récepteurs immunologiques (immunologie), Souris de lignée C57BL, Souris knockout, Vaccination (), Vaccins (administration et posologie), Vaccins (immunologie).
- MESH :
- administration et posologie : Vaccins.
- immunologie : Anticorps, Antigènes CD, Antigènes CD11b, Antigènes CD11c, Antigènes CD40, Antigènes d'histocompatibilité de classe I, Antigènes d'histocompatibilité de classe II, Cellules dendritiques, Endocytose, Lectines de type C, Présentation d'antigène, Récepteurs de surface cellulaire, Récepteurs immunologiques, Vaccins.
- métabolisme : Antigènes CD, Cellules dendritiques.
- Animaux, Antigènes mineurs d'histocompatibilité, Cellules cultivées, Humains, Souris de lignée C57BL, Souris knockout, Vaccination.
English descriptors
- KwdEn :
- Animals, Antibodies (immunology), Antigen Presentation (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Antigens, CD11b (immunology), Antigens, CD11c (immunology), Antigens, CD40 (immunology), Cells, Cultured, Dendritic Cells (immunology), Dendritic Cells (metabolism), Endocytosis (immunology), Histocompatibility Antigens Class I (immunology), Histocompatibility Antigens Class II (immunology), Humans, Lectins, C-Type (immunology), Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens, Receptors, Cell Surface (immunology), Receptors, Immunologic (immunology), Vaccination (methods), Vaccines (administration & dosage), Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines.
- chemical , immunology : Antibodies, Antigens, CD, Antigens, CD11b, Antigens, CD11c, Antigens, CD40, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Lectins, C-Type, Receptors, Cell Surface, Receptors, Immunologic, Vaccines.
- immunology : Antigen Presentation, Dendritic Cells, Endocytosis.
- chemical , metabolism : Antigens, CD, Dendritic Cells.
- methods : Vaccination.
- Animals, Cells, Cultured, Humans, Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens.
Abstract
Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.
DOI: 10.4049/jimmunol.1402535
PubMed: 25653426
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pubmed:25653426Le document en format XML
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<author><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name>
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<author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name>
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<author><name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name>
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<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
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<author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name>
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<author><name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies (immunology)</term>
<term>Antigen Presentation (immunology)</term>
<term>Antigens, CD (immunology)</term>
<term>Antigens, CD (metabolism)</term>
<term>Antigens, CD11b (immunology)</term>
<term>Antigens, CD11c (immunology)</term>
<term>Antigens, CD40 (immunology)</term>
<term>Cells, Cultured</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (metabolism)</term>
<term>Endocytosis (immunology)</term>
<term>Histocompatibility Antigens Class I (immunology)</term>
<term>Histocompatibility Antigens Class II (immunology)</term>
<term>Humans</term>
<term>Lectins, C-Type (immunology)</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
<term>Receptors, Cell Surface (immunology)</term>
<term>Receptors, Immunologic (immunology)</term>
<term>Vaccination (methods)</term>
<term>Vaccines (administration & dosage)</term>
<term>Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps (immunologie)</term>
<term>Antigènes CD (immunologie)</term>
<term>Antigènes CD (métabolisme)</term>
<term>Antigènes CD11b (immunologie)</term>
<term>Antigènes CD11c (immunologie)</term>
<term>Antigènes CD40 (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe I (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe II (immunologie)</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (métabolisme)</term>
<term>Endocytose (immunologie)</term>
<term>Humains</term>
<term>Lectines de type C (immunologie)</term>
<term>Présentation d'antigène (immunologie)</term>
<term>Récepteurs de surface cellulaire (immunologie)</term>
<term>Récepteurs immunologiques (immunologie)</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination ()</term>
<term>Vaccins (administration et posologie)</term>
<term>Vaccins (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term>
<term>Antigens, CD</term>
<term>Antigens, CD11b</term>
<term>Antigens, CD11c</term>
<term>Antigens, CD40</term>
<term>Histocompatibility Antigens Class I</term>
<term>Histocompatibility Antigens Class II</term>
<term>Lectins, C-Type</term>
<term>Receptors, Cell Surface</term>
<term>Receptors, Immunologic</term>
<term>Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term>
<term>Antigènes CD</term>
<term>Antigènes CD11b</term>
<term>Antigènes CD11c</term>
<term>Antigènes CD40</term>
<term>Antigènes d'histocompatibilité de classe I</term>
<term>Antigènes d'histocompatibilité de classe II</term>
<term>Cellules dendritiques</term>
<term>Endocytose</term>
<term>Lectines de type C</term>
<term>Présentation d'antigène</term>
<term>Récepteurs de surface cellulaire</term>
<term>Récepteurs immunologiques</term>
<term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen Presentation</term>
<term>Dendritic Cells</term>
<term>Endocytosis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term>
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term>
<term>Cellules dendritiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</div>
</front>
</TEI>
</record>
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