AustralieFrV1, Main, Curation, bibRecord, 002F77

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Identifieur interne : 002F77 ( Main/Curation ); précédent : 002F76; suivant : 002F78

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Auteurs : Anika Reuter [Allemagne] ; Scott E. Panozza [Australie] ; Christophe Macri [Australie] ; Claire Dumont [Australie] ; Jessica Li [Australie] ; Haiyin Liu [Australie] ; Elodie Segura [France] ; Javier Vega-Ramos [Australie] ; Nishma Gupta [Australie] ; Irina Caminschi [Australie] ; Jose A. Villadangos [Australie] ; Angus P R. Johnston [Australie] ; Justine D. Mintern [Australie]

Source :

Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2015.

RBID : pubmed:25653426

Descripteurs français

English descriptors

KwdEn :
- Animals, Antibodies (immunology), Antigen Presentation (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Antigens, CD11b (immunology), Antigens, CD11c (immunology), Antigens, CD40 (immunology), Cells, Cultured, Dendritic Cells (immunology), Dendritic Cells (metabolism), Endocytosis (immunology), Histocompatibility Antigens Class I (immunology), Histocompatibility Antigens Class II (immunology), Humans, Lectins, C-Type (immunology), Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens, Receptors, Cell Surface (immunology), Receptors, Immunologic (immunology), Vaccination (methods), Vaccines (administration & dosage), Vaccines (immunology).
MESH :
- chemical , administration & dosage : Vaccines.
- chemical , immunology : Antibodies, Antigens, CD, Antigens, CD11b, Antigens, CD11c, Antigens, CD40, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Lectins, C-Type, Receptors, Cell Surface, Receptors, Immunologic, Vaccines.
- immunology : Antigen Presentation, Dendritic Cells, Endocytosis.
- chemical , metabolism : Antigens, CD, Dendritic Cells.
- methods : Vaccination.
- Animals, Cells, Cultured, Humans, Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens.

Abstract

Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.

DOI: 10.4049/jimmunol.1402535
PubMed: 25653426

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002F37
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :002E59
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E59
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002235
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :002235
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002235
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002F78

Links to Exploration step

pubmed:25653426

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.</title>
<author><name sortKey="Reuter, Anika" sort="Reuter, Anika" uniqKey="Reuter A" first="Anika" last="Reuter">Anika Reuter</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz, Germany;</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz</wicri:regionArea>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Panozza, Scott E" sort="Panozza, Scott E" uniqKey="Panozza S" first="Scott E" last="Panozza">Scott E. Panozza</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macri, Christophe" sort="Macri, Christophe" uniqKey="Macri C" first="Christophe" last="Macri">Christophe Macri</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dumont, Claire" sort="Dumont, Claire" uniqKey="Dumont C" first="Claire" last="Dumont">Claire Dumont</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jessica" sort="Li, Jessica" uniqKey="Li J" first="Jessica" last="Li">Jessica Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004</wicri:regionArea>
<wicri:noRegion>Victoria 3004</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Haiyin" sort="Liu, Haiyin" uniqKey="Liu H" first="Haiyin" last="Liu">Haiyin Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05</wicri:regionArea>
<wicri:noRegion>75248 Paris Cedex 05</wicri:noRegion>
<wicri:noRegion>75248 Paris Cedex 05</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name>
<affiliation wicri:level="4"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name>
<affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25653426</idno>
<idno type="pmid">25653426</idno>
<idno type="doi">10.4049/jimmunol.1402535</idno>
<idno type="wicri:Area/PubMed/Corpus">002F37</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F37</idno>
<idno type="wicri:Area/PubMed/Curation">002E59</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002E59</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002E59</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002E59</idno>
<idno type="wicri:Area/Ncbi/Merge">002235</idno>
<idno type="wicri:Area/Ncbi/Curation">002235</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002235</idno>
<idno type="wicri:Area/Main/Merge">002F78</idno>
<idno type="wicri:Area/Main/Curation">002F77</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.</title>
<author><name sortKey="Reuter, Anika" sort="Reuter, Anika" uniqKey="Reuter A" first="Anika" last="Reuter">Anika Reuter</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz, Germany;</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz</wicri:regionArea>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
<wicri:noRegion>55099 Mainz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Panozza, Scott E" sort="Panozza, Scott E" uniqKey="Panozza S" first="Scott E" last="Panozza">Scott E. Panozza</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macri, Christophe" sort="Macri, Christophe" uniqKey="Macri C" first="Christophe" last="Macri">Christophe Macri</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dumont, Claire" sort="Dumont, Claire" uniqKey="Dumont C" first="Claire" last="Dumont">Claire Dumont</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jessica" sort="Li, Jessica" uniqKey="Li J" first="Jessica" last="Li">Jessica Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004</wicri:regionArea>
<wicri:noRegion>Victoria 3004</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Haiyin" sort="Liu, Haiyin" uniqKey="Liu H" first="Haiyin" last="Liu">Haiyin Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05</wicri:regionArea>
<wicri:noRegion>75248 Paris Cedex 05</wicri:noRegion>
<wicri:noRegion>75248 Paris Cedex 05</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name>
<affiliation wicri:level="4"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name>
<affiliation wicri:level="1"><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052</wicri:regionArea>
<wicri:noRegion>Victoria 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</nlm:affiliation>
<country wicri:rule="url">Australie</country>
<wicri:regionArea>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title>
<idno type="eISSN">1550-6606</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies (immunology)</term>
<term>Antigen Presentation (immunology)</term>
<term>Antigens, CD (immunology)</term>
<term>Antigens, CD (metabolism)</term>
<term>Antigens, CD11b (immunology)</term>
<term>Antigens, CD11c (immunology)</term>
<term>Antigens, CD40 (immunology)</term>
<term>Cells, Cultured</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (metabolism)</term>
<term>Endocytosis (immunology)</term>
<term>Histocompatibility Antigens Class I (immunology)</term>
<term>Histocompatibility Antigens Class II (immunology)</term>
<term>Humans</term>
<term>Lectins, C-Type (immunology)</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
<term>Receptors, Cell Surface (immunology)</term>
<term>Receptors, Immunologic (immunology)</term>
<term>Vaccination (methods)</term>
<term>Vaccines (administration & dosage)</term>
<term>Vaccines (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps (immunologie)</term>
<term>Antigènes CD (immunologie)</term>
<term>Antigènes CD (métabolisme)</term>
<term>Antigènes CD11b (immunologie)</term>
<term>Antigènes CD11c (immunologie)</term>
<term>Antigènes CD40 (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe I (immunologie)</term>
<term>Antigènes d'histocompatibilité de classe II (immunologie)</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Cellules dendritiques (métabolisme)</term>
<term>Endocytose (immunologie)</term>
<term>Humains</term>
<term>Lectines de type C (immunologie)</term>
<term>Présentation d'antigène (immunologie)</term>
<term>Récepteurs de surface cellulaire (immunologie)</term>
<term>Récepteurs immunologiques (immunologie)</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination ()</term>
<term>Vaccins (administration et posologie)</term>
<term>Vaccins (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term>
<term>Antigens, CD</term>
<term>Antigens, CD11b</term>
<term>Antigens, CD11c</term>
<term>Antigens, CD40</term>
<term>Histocompatibility Antigens Class I</term>
<term>Histocompatibility Antigens Class II</term>
<term>Lectins, C-Type</term>
<term>Receptors, Cell Surface</term>
<term>Receptors, Immunologic</term>
<term>Vaccines</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps</term>
<term>Antigènes CD</term>
<term>Antigènes CD11b</term>
<term>Antigènes CD11c</term>
<term>Antigènes CD40</term>
<term>Antigènes d'histocompatibilité de classe I</term>
<term>Antigènes d'histocompatibilité de classe II</term>
<term>Cellules dendritiques</term>
<term>Endocytose</term>
<term>Lectines de type C</term>
<term>Présentation d'antigène</term>
<term>Récepteurs de surface cellulaire</term>
<term>Récepteurs immunologiques</term>
<term>Vaccins</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen Presentation</term>
<term>Dendritic Cells</term>
<term>Endocytosis</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term>
<term>Dendritic Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term>
<term>Cellules dendritiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Humans</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Minor Histocompatibility Antigens</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Antigènes mineurs d'histocompatibilité</term>
<term>Cellules cultivées</term>
<term>Humains</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Vaccination</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F77 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002F77 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:25653426
   |texte=   Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i   -Sk "pubmed:25653426" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki