Serveur d'exploration sur les relations entre la France et l'Australie

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Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.

Identifieur interne : 002E59 ( PubMed/Checkpoint ); précédent : 002E58; suivant : 002E60

Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.

Auteurs : Timothy J. Key [Royaume-Uni] ; Paul N. Appleby ; Ruth C. Travis ; Demetrius Albanes [États-Unis] ; Anthony J. Alberg [États-Unis] ; Aurelio Barricarte [Espagne] ; Amanda Black [États-Unis] ; Heiner Boeing [Allemagne] ; H Bas Bueno-De-Mesquita [Royaume-Uni] ; June M. Chan [États-Unis] ; Chu Chen ; Michael B. Cook [États-Unis] ; Jenny L. Donovan [Royaume-Uni] ; Pilar Galan [France] ; Rebecca Gilbert [Royaume-Uni] ; Graham G. Giles [Australie] ; Edward Giovannucci [États-Unis] ; Gary E. Goodman [États-Unis] ; Phyllis J. Goodman ; Marc J. Gunter [Royaume-Uni] ; Freddie C. Hamdy ; Markku Heliövaara [Finlande] ; Kathy J. Helzlsouer [États-Unis] ; Brian E. Henderson [États-Unis] ; Serge Hercberg [France] ; Judy Hoffman-Bolton [États-Unis] ; Robert N. Hoover [États-Unis] ; Mattias Johansson [Suède] ; Kay-Tee Khaw ; Irena B. King [États-Unis] ; Paul Knekt [Finlande] ; Laurence N. Kolonel [États-Unis] ; Loic Le Marchand [États-Unis] ; Satu M Nnistö [Finlande] ; Richard M. Martin [Royaume-Uni] ; Haakon E. Meyer [Norvège] ; Alison M. Mondul [États-Unis] ; Kristin A. Moy [États-Unis] ; David E. Neal [Royaume-Uni] ; Marian L. Neuhouser ; Domenico Palli [Italie] ; Elizabeth A. Platz [États-Unis] ; Camille Pouchieu [Australie] ; Harri Rissanen [Finlande] ; Jeannette M. Schenk [États-Unis] ; Gianluca Severi [Australie] ; Meir J. Stampfer [États-Unis] ; Anne Tj Nneland [Danemark] ; Mathilde Touvier [France] ; Antonia Trichopoulou ; Stephanie J. Weinstein [États-Unis] ; Regina G. Ziegler [États-Unis] ; Cindy Ke Zhou [États-Unis] ; Naomi E. Allen [Royaume-Uni]

Source :

RBID : pubmed:26447150

Descripteurs français

English descriptors

Abstract

Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.

DOI: 10.3945/ajcn.115.114306
PubMed: 26447150


Affiliations:


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pubmed:26447150

Le document en format XML

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<name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
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<name sortKey="King, Irena B" sort="King, Irena B" uniqKey="King I" first="Irena B" last="King">Irena B. King</name>
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<name sortKey="M Nnisto, Satu" sort="M Nnisto, Satu" uniqKey="M Nnisto S" first="Satu" last="M Nnistö">Satu M Nnistö</name>
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<nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</nlm:affiliation>
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<region type="state">Massachusetts</region>
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<title xml:lang="en">Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies.</title>
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<name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name>
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<name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name>
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<nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, San Francisco, CA;</nlm:affiliation>
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<region type="state">Californie</region>
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<name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
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<name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name>
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<name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
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<name sortKey="Gilbert, Rebecca" sort="Gilbert, Rebecca" uniqKey="Gilbert R" first="Rebecca" last="Gilbert">Rebecca Gilbert</name>
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<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
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<name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name>
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<name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name>
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<div type="abstract" xml:lang="en">Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</div>
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<ELocationID EIdType="doi" ValidYN="Y">10.3945/ajcn.115.114306</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, α-tocopherol, and γ-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For α-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). γ-Tocopherol was not associated with risk.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Overall prostate cancer risk was positively associated with retinol and inversely associated with α-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and α-tocopherol. Whether these associations reflect causal relations is unclear.</AbstractText>
<CopyrightInformation>© 2015 American Society for Nutrition.</CopyrightInformation>
</Abstract>
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<ForeName>Timothy J</ForeName>
<Initials>TJ</Initials>
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<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, tim.key@ceu.ox.ac.uk.</Affiliation>
</AffiliationInfo>
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<LastName>Appleby</LastName>
<ForeName>Paul N</ForeName>
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<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health.</Affiliation>
</AffiliationInfo>
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<LastName>Travis</LastName>
<ForeName>Ruth C</ForeName>
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<Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health.</Affiliation>
</AffiliationInfo>
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<ForeName>Demetrius</ForeName>
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<ForeName>Anthony J</ForeName>
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<ForeName>Aurelio</ForeName>
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<Affiliation>Navarre Public Health Institute, Pamplona, Spain, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Spain;</Affiliation>
</AffiliationInfo>
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<LastName>Black</LastName>
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<ForeName>Heiner</ForeName>
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<Affiliation>Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany;</Affiliation>
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<LastName>Hoffman-Bolton</LastName>
<ForeName>Judy</ForeName>
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<Affiliation>George W Comstock Center for Public Health Research and Prevention, Hagerstown, MD;</Affiliation>
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<ForeName>Mattias</ForeName>
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<ForeName>Irena B</ForeName>
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<ForeName>Laurence N</ForeName>
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<ForeName>Richard M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo>
<Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, United Kingdom;</Affiliation>
</AffiliationInfo>
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<ForeName>Haakon E</ForeName>
<Initials>HE</Initials>
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<Affiliation>Department of Community Medicine, Faculty of Medicine, University of Oslo and Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;</Affiliation>
</AffiliationInfo>
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<LastName>Mondul</LastName>
<ForeName>Alison M</ForeName>
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<LastName>Moy</LastName>
<ForeName>Kristin A</ForeName>
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<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
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<LastName>Neal</LastName>
<ForeName>David E</ForeName>
<Initials>DE</Initials>
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<Affiliation>Department of Oncology, University of Cambridge, Cambridge, United Kingdom;</Affiliation>
</AffiliationInfo>
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<LastName>Neuhouser</LastName>
<ForeName>Marian L</ForeName>
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<LastName>Palli</LastName>
<ForeName>Domenico</ForeName>
<Initials>D</Initials>
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<Affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy;</Affiliation>
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<LastName>Platz</LastName>
<ForeName>Elizabeth A</ForeName>
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<AffiliationInfo>
<Affiliation>Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;</Affiliation>
</AffiliationInfo>
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<LastName>Pouchieu</LastName>
<ForeName>Camille</ForeName>
<Initials>C</Initials>
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</AffiliationInfo>
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<ForeName>Harri</ForeName>
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<LastName>Severi</LastName>
<ForeName>Gianluca</ForeName>
<Initials>G</Initials>
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<Affiliation>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia;</Affiliation>
</AffiliationInfo>
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<LastName>Stampfer</LastName>
<ForeName>Meir J</ForeName>
<Initials>MJ</Initials>
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<Affiliation>Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;</Affiliation>
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<ForeName>Anne</ForeName>
<Initials>A</Initials>
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</AffiliationInfo>
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<LastName>Touvier</LastName>
<ForeName>Mathilde</ForeName>
<Initials>M</Initials>
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<LastName>Trichopoulou</LastName>
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<Initials>A</Initials>
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<Affiliation>Hellenic Health Foundation and Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece and.</Affiliation>
</AffiliationInfo>
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<LastName>Weinstein</LastName>
<ForeName>Stephanie J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
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<LastName>Ziegler</LastName>
<ForeName>Regina G</ForeName>
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<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
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<LastName>Zhou</LastName>
<ForeName>Cindy Ke</ForeName>
<Initials>CK</Initials>
<AffiliationInfo>
<Affiliation>Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD;</Affiliation>
</AffiliationInfo>
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<LastName>Allen</LastName>
<ForeName>Naomi E</ForeName>
<Initials>NE</Initials>
<AffiliationInfo>
<Affiliation>Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom;</Affiliation>
</AffiliationInfo>
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<CollectiveName>Endogenous Hormones Nutritional Biomarkers Prostate Cancer Collaborative Group</CollectiveName>
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<Month>10</Month>
<Day>07</Day>
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<country name="Danemark">
<region name="Hovedstaden">
<name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name>
</region>
</country>
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</affiliations>
</record>

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{{Explor lien
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