Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.
Identifieur interne : 002F37 ( PubMed/Corpus ); précédent : 002F36; suivant : 002F38Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.
Auteurs : Anika Reuter ; Scott E. Panozza ; Christophe Macri ; Claire Dumont ; Jessica Li ; Haiyin Liu ; Elodie Segura ; Javier Vega-Ramos ; Nishma Gupta ; Irina Caminschi ; Jose A. Villadangos ; Angus P R. Johnston ; Justine D. MinternSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2015.
English descriptors
- KwdEn :
- Animals, Antibodies (immunology), Antigen Presentation (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Antigens, CD11b (immunology), Antigens, CD11c (immunology), Antigens, CD40 (immunology), Cells, Cultured, Dendritic Cells (immunology), Dendritic Cells (metabolism), Endocytosis (immunology), Histocompatibility Antigens Class I (immunology), Histocompatibility Antigens Class II (immunology), Humans, Lectins, C-Type (immunology), Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens, Receptors, Cell Surface (immunology), Receptors, Immunologic (immunology), Vaccination (methods), Vaccines (administration & dosage), Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines.
- chemical , immunology : Antibodies, Antigens, CD, Antigens, CD11b, Antigens, CD11c, Antigens, CD40, Histocompatibility Antigens Class I, Histocompatibility Antigens Class II, Lectins, C-Type, Receptors, Cell Surface, Receptors, Immunologic, Vaccines.
- immunology : Antigen Presentation, Dendritic Cells, Endocytosis.
- chemical , metabolism : Antigens, CD, Dendritic Cells.
- methods : Vaccination.
- Animals, Cells, Cultured, Humans, Mice, Inbred C57BL, Mice, Knockout, Minor Histocompatibility Antigens.
Abstract
Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.
DOI: 10.4049/jimmunol.1402535
PubMed: 25653426
Links to Exploration step
pubmed:25653426Le document en format XML
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Panozza</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Macri, Christophe" sort="Macri, Christophe" uniqKey="Macri C" first="Christophe" last="Macri">Christophe Macri</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Dumont, Claire" sort="Dumont, Claire" uniqKey="Dumont C" first="Claire" last="Dumont">Claire Dumont</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jessica" sort="Li, Jessica" uniqKey="Li J" first="Jessica" last="Li">Jessica Li</name><affiliation><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Haiyin" sort="Liu, Haiyin" uniqKey="Liu H" first="Haiyin" last="Liu">Haiyin Liu</name><affiliation><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name><affiliation><nlm:affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</nlm:affiliation></affiliation></author><author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name><affiliation><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name><affiliation><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name><affiliation><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name><affiliation><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25653426</idno><idno type="pmid">25653426</idno><idno type="doi">10.4049/jimmunol.1402535</idno><idno type="wicri:Area/PubMed/Corpus">002F37</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002F37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.</title><author><name sortKey="Reuter, Anika" sort="Reuter, Anika" uniqKey="Reuter A" first="Anika" last="Reuter">Anika Reuter</name><affiliation><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz, Germany;</nlm:affiliation></affiliation></author><author><name sortKey="Panozza, Scott E" sort="Panozza, Scott E" uniqKey="Panozza S" first="Scott E" last="Panozza">Scott E. Panozza</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Macri, Christophe" sort="Macri, Christophe" uniqKey="Macri C" first="Christophe" last="Macri">Christophe Macri</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Dumont, Claire" sort="Dumont, Claire" uniqKey="Dumont C" first="Claire" last="Dumont">Claire Dumont</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jessica" sort="Li, Jessica" uniqKey="Li J" first="Jessica" last="Li">Jessica Li</name><affiliation><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Haiyin" sort="Liu, Haiyin" uniqKey="Liu H" first="Haiyin" last="Liu">Haiyin Liu</name><affiliation><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Segura, Elodie" sort="Segura, Elodie" uniqKey="Segura E" first="Elodie" last="Segura">Elodie Segura</name><affiliation><nlm:affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</nlm:affiliation></affiliation></author><author><name sortKey="Vega Ramos, Javier" sort="Vega Ramos, Javier" uniqKey="Vega Ramos J" first="Javier" last="Vega-Ramos">Javier Vega-Ramos</name><affiliation><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Nishma" sort="Gupta, Nishma" uniqKey="Gupta N" first="Nishma" last="Gupta">Nishma Gupta</name><affiliation><nlm:affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</nlm:affiliation></affiliation></author><author><name sortKey="Caminschi, Irina" sort="Caminschi, Irina" uniqKey="Caminschi I" first="Irina" last="Caminschi">Irina Caminschi</name><affiliation><nlm:affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Villadangos, Jose A" sort="Villadangos, Jose A" uniqKey="Villadangos J" first="Jose A" last="Villadangos">Jose A. Villadangos</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</nlm:affiliation></affiliation></author><author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P R" last="Johnston">Angus P R. Johnston</name><affiliation><nlm:affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mintern, Justine D" sort="Mintern, Justine D" uniqKey="Mintern J" first="Justine D" last="Mintern">Justine D. Mintern</name><affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of immunology (Baltimore, Md. : 1950)</title><idno type="eISSN">1550-6606</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies (immunology)</term><term>Antigen Presentation (immunology)</term><term>Antigens, CD (immunology)</term><term>Antigens, CD (metabolism)</term><term>Antigens, CD11b (immunology)</term><term>Antigens, CD11c (immunology)</term><term>Antigens, CD40 (immunology)</term><term>Cells, Cultured</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (metabolism)</term><term>Endocytosis (immunology)</term><term>Histocompatibility Antigens Class I (immunology)</term><term>Histocompatibility Antigens Class II (immunology)</term><term>Humans</term><term>Lectins, C-Type (immunology)</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Minor Histocompatibility Antigens</term><term>Receptors, Cell Surface (immunology)</term><term>Receptors, Immunologic (immunology)</term><term>Vaccination (methods)</term><term>Vaccines (administration & dosage)</term><term>Vaccines (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies</term><term>Antigens, CD</term><term>Antigens, CD11b</term><term>Antigens, CD11c</term><term>Antigens, CD40</term><term>Histocompatibility Antigens Class I</term><term>Histocompatibility Antigens Class II</term><term>Lectins, C-Type</term><term>Receptors, Cell Surface</term><term>Receptors, Immunologic</term><term>Vaccines</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antigen Presentation</term><term>Dendritic Cells</term><term>Endocytosis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term><term>Dendritic Cells</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Humans</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Minor Histocompatibility Antigens</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25653426</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>09</Day></DateCreated><DateCompleted><Year>2015</Year><Month>06</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1550-6606</ISSN><JournalIssue CitedMedium="Internet"><Volume>194</Volume><Issue>6</Issue><PubDate><Year>2015</Year><Month>Mar</Month><Day>15</Day></PubDate></JournalIssue><Title>Journal of immunology (Baltimore, Md. : 1950)</Title><ISOAbbreviation>J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.</ArticleTitle><Pagination><MedlinePgn>2696-705</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4049/jimmunol.1402535</ELocationID><Abstract><AbstractText>Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameters of DC receptor internalization and determined how they impact Ag presentation outcomes. First, using mixed bone marrow chimeras, we established that Ag-targeted, but not nontargeted, DCs are responsible for Ag presentation in settings of Ab-targeted vaccination in vivo. Next, we analyzed parameters of DEC205 (CD205), Clec9A, CD11c, CD11b, and CD40 endocytosis and obtained quantitative measurements of internalization speed, surface turnover, and delivered Ag load. Exploiting these parameters in MHC class I (MHC I) and MHC class II (MHC II) Ag presentation assays, we showed that receptor expression level, proportion of surface turnover, or speed of receptor internalization did not impact MHC I or MHC II Ag presentation efficiency. Furthermore, the Ag load delivered to DCs did not correlate with the efficiency of MHC I or MHC II Ag presentation. In contrast, targeting Ag to CD8(+) or CD8(-) DCs enhanced MHC I or MHC II Ag presentation, respectively. Therefore, receptor expression levels, speed of internalization, and/or the amount of Ag delivered can be excluded as major determinants that dictate Ag presentation efficiency in setting of Ab-targeted vaccination.</AbstractText><CopyrightInformation>Copyright © 2015 by The American Association of Immunologists, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Reuter</LastName><ForeName>Anika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Max Planck Graduate Center, 55128 Mainz, Germany; Institute of Physical Chemistry, 55099 Mainz, Germany;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panozza</LastName><ForeName>Scott E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macri</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dumont</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Haiyin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Segura</LastName><ForeName>Elodie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>INSERM Unité 932, 75248 Paris Cedex 05, France; Institut Curie, Centre de Recherche, 75248 Paris Cedex 05, France;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vega-Ramos</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Nishma</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia;</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caminschi</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villadangos</LastName><ForeName>Jose A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia; and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnston</LastName><ForeName>Angus P R</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mintern</LastName><ForeName>Justine D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia; jmintern@unimelb.edu.au angus.johnston@monash.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Immunol</MedlineTA><NlmUniqueID>2985117R</NlmUniqueID><ISSNLinking>0022-1767</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000906">Antibodies</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015703">Antigens, CD</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D039481">Antigens, 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Histocompatibility Antigens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011956">Receptors, Cell Surface</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011971">Receptors, Immunologic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014612">Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000906" MajorTopicYN="N">Antibodies</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017951" MajorTopicYN="N">Antigen Presentation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName 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UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015778" MajorTopicYN="N">Minor Histocompatibility Antigens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011956" MajorTopicYN="N">Receptors, Cell Surface</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011971" MajorTopicYN="N">Receptors, Immunologic</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014612" MajorTopicYN="N">Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>6</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25653426</ArticleId><ArticleId IdType="pii">jimmunol.1402535</ArticleId><ArticleId IdType="doi">10.4049/jimmunol.1402535</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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