Clinical features at first visit and rapid disease progression in Parkinson's disease.
Identifieur interne : 000883 ( Ncbi/Checkpoint ); précédent : 000882; suivant : 000884Clinical features at first visit and rapid disease progression in Parkinson's disease.
Auteurs : Leslie W. Ferguson [Canada] ; Michele L. Rajput ; Nazeem Muhajarine ; Syed M. Shah ; Alexander RajputSource :
- Parkinsonism & related disorders [ 1353-8020 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- epidemiology : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Multivariate Analysis, Retrospective Studies.
Abstract
We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.
DOI: 10.1016/j.parkreldis.2007.10.012
PubMed: 18321757
Affiliations:
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pubmed:18321757Le document en format XML
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<term>Multivariate Analysis</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
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<front><div type="abstract" xml:lang="en">We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.</div>
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