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Clinical features at first visit and rapid disease progression in Parkinson's disease.

Identifieur interne : 001026 ( PubMed/Curation ); précédent : 001025; suivant : 001027

Clinical features at first visit and rapid disease progression in Parkinson's disease.

Auteurs : Leslie W. Ferguson [Canada] ; Michele L. Rajput ; Nazeem Muhajarine ; Syed M. Shah ; Alexander Rajput

Source :

Parkinsonism & related disorders [ 1353-8020 ] ; 2008.

RBID : pubmed:18321757

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Multivariate Analysis, Parkinson Disease (complications), Parkinson Disease (epidemiology), Retrospective Studies.
MESH :
- complications : Parkinson Disease.
- epidemiology : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Multivariate Analysis, Retrospective Studies.

Abstract

We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.

DOI: 10.1016/j.parkreldis.2007.10.012
PubMed: 18321757

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Le document en format XML

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<author><name sortKey="Ferguson, Leslie W" sort="Ferguson, Leslie W" uniqKey="Ferguson L" first="Leslie W" last="Ferguson">Leslie W. Ferguson</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada. lwf127@mail.usask.ca</nlm:affiliation>
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<wicri:regionArea>Division of Neurology, Royal University Hospital, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8</wicri:regionArea>
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<author><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L" last="Rajput">Michele L. Rajput</name>
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<front><div type="abstract" xml:lang="en">We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.</div>
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<Abstract><AbstractText>We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.</AbstractText>
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Clinical features at first visit and rapid disease progression in Parkinson's disease.

Clinical features at first visit and rapid disease progression in Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki