Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Identifieur interne : 001026 ( PubMed/Checkpoint ); précédent : 001025; suivant : 001027Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
Auteurs : B. Rajakumar [Canada] ; B A Flumerfelt ; A W Hrycyshyn ; N. RajakumarSource :
- Cell transplantation [ 0963-6897 ] ; 2007.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (drug effects), Brain Tissue Transplantation, Choline (metabolism), Disease Models, Animal, Female, Indazoles (pharmacology), Methamphetamine (pharmacology), NADPH Dehydrogenase (metabolism), Neostriatum (drug effects), Neurons (drug effects), Neurons (enzymology), Neurons (metabolism), Neurons (pathology), Nitric Oxide (metabolism), Parkinson Disease (pathology), Pedunculopontine Tegmental Nucleus (drug effects), Pedunculopontine Tegmental Nucleus (metabolism), Pedunculopontine Tegmental Nucleus (pathology), Pregnancy, Rats, Rats, Sprague-Dawley, Rotation, Somatostatin (metabolism), Time Factors, Tyrosine 3-Monooxygenase (metabolism), Ventral Tegmental Area (drug effects), Ventral Tegmental Area (metabolism), Ventral Tegmental Area (pathology).
- MESH :
- chemical , metabolism : Choline, NADPH Dehydrogenase, Nitric Oxide, Somatostatin, Tyrosine 3-Monooxygenase.
- drug effects : Behavior, Animal, Neostriatum, Neurons, Pedunculopontine Tegmental Nucleus, Ventral Tegmental Area.
- enzymology : Neurons.
- metabolism : Neurons, Pedunculopontine Tegmental Nucleus, Ventral Tegmental Area.
- pathology : Neurons, Parkinson Disease, Pedunculopontine Tegmental Nucleus, Ventral Tegmental Area.
- chemical , pharmacology : Indazoles, Methamphetamine.
- Animals, Brain Tissue Transplantation, Disease Models, Animal, Female, Pregnancy, Rats, Rats, Sprague-Dawley, Rotation, Time Factors.
Abstract
The role that nitric oxide may play in modulating graft function in long-term fetal ventral mesencephalic grafts in an animal model of Parkinson's disease was investigated. Mature grafts harvested from the entire fetal ventral mesencephalon possessed a large number of neuronal nitric oxide synthase (nNOS)/NADPH-diaphorase-containing neurons throughout the graft intermingled with dopaminergic neurons. The morphological and neurochemical characteristics of these NADPH-diaphorase neurons resembled those in centers adjacent to the substantia nigra of adult brain but not that of the striatum. Pretreatment with the nNOS blocker, 7-nitroindazole, resulted in contralateral rotations following methamphetamine challenge in long-term grafted animals that previously showed normalized rotational behavior. In contrast, mature grafts derived from fetal ventral mesencephalon without the midline areas possessed only a few nNOS-containing neurons within the grafts, and a similar methamphetamine challenge following 7-nitroindazole pretreatment in long-term grafted rats that previously showed normalized rotational behavior resulted in random movements. Our results indicate that nitric oxide-containing neurons inadvertently included during grafting may affect graft function, and excluding the midline areas of the ventral mesencephalon during tissue harvesting may minimize this effect.
PubMed: 17708335
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:17708335Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.</title><author><name sortKey="Rajakumar, B" sort="Rajakumar, B" uniqKey="Rajakumar B" first="B" last="Rajakumar">B. Rajakumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Flumerfelt, B A" sort="Flumerfelt, B A" uniqKey="Flumerfelt B" first="B A" last="Flumerfelt">B A Flumerfelt</name></author><author><name sortKey="Hrycyshyn, A W" sort="Hrycyshyn, A W" uniqKey="Hrycyshyn A" first="A W" last="Hrycyshyn">A W Hrycyshyn</name></author><author><name sortKey="Rajakumar, N" sort="Rajakumar, N" uniqKey="Rajakumar N" first="N" last="Rajakumar">N. Rajakumar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17708335</idno><idno type="pmid">17708335</idno><idno type="wicri:Area/PubMed/Corpus">001101</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001101</idno><idno type="wicri:Area/PubMed/Curation">001101</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001101</idno><idno type="wicri:Area/PubMed/Checkpoint">001101</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001101</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.</title><author><name sortKey="Rajakumar, B" sort="Rajakumar, B" uniqKey="Rajakumar B" first="B" last="Rajakumar">B. Rajakumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Flumerfelt, B A" sort="Flumerfelt, B A" uniqKey="Flumerfelt B" first="B A" last="Flumerfelt">B A Flumerfelt</name></author><author><name sortKey="Hrycyshyn, A W" sort="Hrycyshyn, A W" uniqKey="Hrycyshyn A" first="A W" last="Hrycyshyn">A W Hrycyshyn</name></author><author><name sortKey="Rajakumar, N" sort="Rajakumar, N" uniqKey="Rajakumar N" first="N" last="Rajakumar">N. Rajakumar</name></author></analytic><series><title level="j">Cell transplantation</title><idno type="ISSN">0963-6897</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Behavior, Animal (drug effects)</term><term>Brain Tissue Transplantation</term><term>Choline (metabolism)</term><term>Disease Models, Animal</term><term>Female</term><term>Indazoles (pharmacology)</term><term>Methamphetamine (pharmacology)</term><term>NADPH Dehydrogenase (metabolism)</term><term>Neostriatum (drug effects)</term><term>Neurons (drug effects)</term><term>Neurons (enzymology)</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Nitric Oxide (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Pedunculopontine Tegmental Nucleus (drug effects)</term><term>Pedunculopontine Tegmental Nucleus (metabolism)</term><term>Pedunculopontine Tegmental Nucleus (pathology)</term><term>Pregnancy</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rotation</term><term>Somatostatin (metabolism)</term><term>Time Factors</term><term>Tyrosine 3-Monooxygenase (metabolism)</term><term>Ventral Tegmental Area (drug effects)</term><term>Ventral Tegmental Area (metabolism)</term><term>Ventral Tegmental Area (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Choline</term><term>NADPH Dehydrogenase</term><term>Nitric Oxide</term><term>Somatostatin</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Neostriatum</term><term>Neurons</term><term>Pedunculopontine Tegmental Nucleus</term><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Pedunculopontine Tegmental Nucleus</term><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurons</term><term>Parkinson Disease</term><term>Pedunculopontine Tegmental Nucleus</term><term>Ventral Tegmental Area</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Indazoles</term><term>Methamphetamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brain Tissue Transplantation</term><term>Disease Models, Animal</term><term>Female</term><term>Pregnancy</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Rotation</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role that nitric oxide may play in modulating graft function in long-term fetal ventral mesencephalic grafts in an animal model of Parkinson's disease was investigated. Mature grafts harvested from the entire fetal ventral mesencephalon possessed a large number of neuronal nitric oxide synthase (nNOS)/NADPH-diaphorase-containing neurons throughout the graft intermingled with dopaminergic neurons. The morphological and neurochemical characteristics of these NADPH-diaphorase neurons resembled those in centers adjacent to the substantia nigra of adult brain but not that of the striatum. Pretreatment with the nNOS blocker, 7-nitroindazole, resulted in contralateral rotations following methamphetamine challenge in long-term grafted animals that previously showed normalized rotational behavior. In contrast, mature grafts derived from fetal ventral mesencephalon without the midline areas possessed only a few nNOS-containing neurons within the grafts, and a similar methamphetamine challenge following 7-nitroindazole pretreatment in long-term grafted rats that previously showed normalized rotational behavior resulted in random movements. Our results indicate that nitric oxide-containing neurons inadvertently included during grafting may affect graft function, and excluding the midline areas of the ventral mesencephalon during tissue harvesting may minimize this effect.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17708335</PMID><DateCreated><Year>2007</Year><Month>08</Month><Day>21</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0963-6897</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>5</Issue><PubDate><Year>2007</Year></PubDate></JournalIssue><Title>Cell transplantation</Title><ISOAbbreviation>Cell Transplant</ISOAbbreviation></Journal><ArticleTitle>Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>449-59</MedlinePgn></Pagination><Abstract><AbstractText>The role that nitric oxide may play in modulating graft function in long-term fetal ventral mesencephalic grafts in an animal model of Parkinson's disease was investigated. Mature grafts harvested from the entire fetal ventral mesencephalon possessed a large number of neuronal nitric oxide synthase (nNOS)/NADPH-diaphorase-containing neurons throughout the graft intermingled with dopaminergic neurons. The morphological and neurochemical characteristics of these NADPH-diaphorase neurons resembled those in centers adjacent to the substantia nigra of adult brain but not that of the striatum. Pretreatment with the nNOS blocker, 7-nitroindazole, resulted in contralateral rotations following methamphetamine challenge in long-term grafted animals that previously showed normalized rotational behavior. In contrast, mature grafts derived from fetal ventral mesencephalon without the midline areas possessed only a few nNOS-containing neurons within the grafts, and a similar methamphetamine challenge following 7-nitroindazole pretreatment in long-term grafted rats that previously showed normalized rotational behavior resulted in random movements. Our results indicate that nitric oxide-containing neurons inadvertently included during grafting may affect graft function, and excluding the midline areas of the ventral mesencephalon during tissue harvesting may minimize this effect.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rajakumar</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Anatomy & Cell Biology, University of Western Ontario, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flumerfelt</LastName><ForeName>B A</ForeName><Initials>BA</Initials></Author><Author ValidYN="Y"><LastName>Hrycyshyn</LastName><ForeName>A W</ForeName><Initials>AW</Initials></Author><Author ValidYN="Y"><LastName>Rajakumar</LastName><ForeName>N</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Transplant</MedlineTA><NlmUniqueID>9208854</NlmUniqueID><ISSNLinking>0963-6897</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007191">Indazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>44RAL3456C</RegistryNumber><NameOfSubstance UI="D008694">Methamphetamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance UI="D013004">Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.16.2</RegistryNumber><NameOfSubstance UI="D014446">Tyrosine 3-Monooxygenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.6.99.1</RegistryNumber><NameOfSubstance UI="D009252">NADPH Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>N91BDP6H0X</RegistryNumber><NameOfSubstance UI="D002794">Choline</NameOfSubstance></Chemical><Chemical><RegistryNumber>UX0N37CMVH</RegistryNumber><NameOfSubstance UI="C080122">7-nitroindazole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016380" MajorTopicYN="Y">Brain Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002794" MajorTopicYN="N">Choline</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007191" MajorTopicYN="N">Indazoles</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008694" MajorTopicYN="N">Methamphetamine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009252" MajorTopicYN="N">NADPH Dehydrogenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017072" MajorTopicYN="N">Neostriatum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045042" MajorTopicYN="N">Pedunculopontine Tegmental Nucleus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012399" MajorTopicYN="N">Rotation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013004" MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014446" MajorTopicYN="N">Tyrosine 3-Monooxygenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017557" MajorTopicYN="N">Ventral Tegmental Area</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>8</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>8</Month><Day>22</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17708335</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Flumerfelt, B A" sort="Flumerfelt, B A" uniqKey="Flumerfelt B" first="B A" last="Flumerfelt">B A Flumerfelt</name><name sortKey="Hrycyshyn, A W" sort="Hrycyshyn, A W" uniqKey="Hrycyshyn A" first="A W" last="Hrycyshyn">A W Hrycyshyn</name><name sortKey="Rajakumar, N" sort="Rajakumar, N" uniqKey="Rajakumar N" first="N" last="Rajakumar">N. Rajakumar</name></noCountry><country name="Canada"><noRegion><name sortKey="Rajakumar, B" sort="Rajakumar, B" uniqKey="Rajakumar B" first="B" last="Rajakumar">B. Rajakumar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001026 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 001026 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PubMed
|étape= Checkpoint
|type= RBID
|clé= pubmed:17708335
|texte= Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:17708335" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |