Clinical features at first visit and rapid disease progression in Parkinson's disease.
Identifieur interne : 001026 ( PubMed/Corpus ); précédent : 001025; suivant : 001027Clinical features at first visit and rapid disease progression in Parkinson's disease.
Auteurs : Leslie W. Ferguson ; Michele L. Rajput ; Nazeem Muhajarine ; Syed M. Shah ; Alexander RajputSource :
- Parkinsonism & related disorders [ 1353-8020 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- epidemiology : Parkinson Disease.
- Adult, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Female, Humans, Male, Middle Aged, Multivariate Analysis, Retrospective Studies.
Abstract
We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.
DOI: 10.1016/j.parkreldis.2007.10.012
PubMed: 18321757
Links to Exploration step
pubmed:18321757Le document en format XML
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<author><name sortKey="Ferguson, Leslie W" sort="Ferguson, Leslie W" uniqKey="Ferguson L" first="Leslie W" last="Ferguson">Leslie W. Ferguson</name>
<affiliation><nlm:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada. lwf127@mail.usask.ca</nlm:affiliation>
</affiliation>
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<author><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L" last="Rajput">Michele L. Rajput</name>
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<author><name sortKey="Muhajarine, Nazeem" sort="Muhajarine, Nazeem" uniqKey="Muhajarine N" first="Nazeem" last="Muhajarine">Nazeem Muhajarine</name>
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<author><name sortKey="Shah, Syed M" sort="Shah, Syed M" uniqKey="Shah S" first="Syed M" last="Shah">Syed M. Shah</name>
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<author><name sortKey="Rajput, Alexander" sort="Rajput, Alexander" uniqKey="Rajput A" first="Alexander" last="Rajput">Alexander Rajput</name>
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<author><name sortKey="Shah, Syed M" sort="Shah, Syed M" uniqKey="Shah S" first="Syed M" last="Shah">Syed M. Shah</name>
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<series><title level="j">Parkinsonism & related disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Retrospective Studies</term>
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<term>Disease Progression</term>
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<front><div type="abstract" xml:lang="en">We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.</div>
</front>
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<Title>Parkinsonism & related disorders</Title>
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<Abstract><AbstractText>We report a retrospective multivariable analysis of the association between patient characteristics at first clinic visit and rapid disease progression in 1411 Parkinson's disease patients treated between 1985 and 2006. At first visit rapid progression was positively associated with age at onset > or = 70 years (OR=5.77), rigidity (OR=1.94), bradykinesia (OR=1.73), dementia (OR=2.61), and levodopa use (OR=1.74). Rapid progression was negatively associated with disease duration (OR=0.52), male sex (OR=0.49), and resting tremor at first visit (OR=0.44). Family history of movement disorders, while significant for univariable analysis, did not retain significance in multivariable analysis. This initial clinical profile may aid physicians in adjusting treatment and follow-up plans. Further prospective studies are needed to evaluate this relationship.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ferguson</LastName>
<ForeName>Leslie W</ForeName>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
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<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
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