Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Identifieur interne : 001915 ( Main/Merge ); précédent : 001914; suivant : 001916Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Auteurs : Alexis Elbaz [France] ; Owen A. Ross [États-Unis] ; John P. A. Ioannidis [Grèce, États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Frédéric Moisan [France] ; Jan Aasly [Norvège] ; Grazia Annesi [Italie] ; Maria Bozi [Grèce] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Alain Destée [France] ; Carlo Ferrarese [Italie] ; Alessandro Ferraris [Italie] ; J. Mark Gibson [Irlande (pays)] ; Suzana Gispert [Allemagne] ; Georgios M. Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne] ; Christine Klein [Allemagne] ; Rejko Krüger [Allemagne] ; Jean-Charles Lambert [France] ; Katja Lohmann [Allemagne] ; Simone Van De Loo [Allemagne] ; Marie-Anne Loriot [France] ; Timothy Lynch [Irlande (pays)] ; George D. Mellick [Australie] ; Eugénie Mutez [France] ; Christer Nilsson [Suède] ; Grzegorz Opala [Pologne] ; Andreas Puschmann [Suède] ; Aldo Quattrone [Italie] ; Manu Sharma [Allemagne] ; Peter A. Silburn [Australie] ; Leonidas Stefanis [Grèce] ; Ryan J. Uitti [États-Unis] ; Enza Maria Valente [Italie] ; Carles Vilari O-Güell [États-Unis, Canada] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis, Canada]Source :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Abstract
We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.
Url:
- https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082599
DOI: 10.1002/ana.22321
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Soto-Ortolaza</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><idno type="DOI">10.1002/ana.22321</idno><idno type="ArticleID">ANA22321</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</div></front></TEI><double doi="10.1002/ana.22321"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22321</idno><idno type="url">https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001865</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001865</idno><idno type="wicri:Area/Istex/Curation">001865</idno><idno type="wicri:Area/Istex/Checkpoint">000422</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000422</idno><idno type="wicri:doubleKey">0364-5134:2011:Elbaz A:independent:and:joint</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13</wicri:regionArea><wicri:noRegion>75651 Paris Cedex 13</wicri:noRegion><wicri:noRegion>75651 Paris Cedex 13</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F‐75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck</wicri:regionArea><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Goethe University, Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>UMR 837 INSERM, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Univ Lille Nord de France, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>University Hospital, CHRU, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens</wicri:regionArea><wicri:noRegion>Athens</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Grèce</country><wicri:regionArea>Institute of Biomedical Research and Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurology, NorthShore University HealthSystem, Evanston</wicri:cityArea></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><idno type="DOI">10.1002/ana.22321</idno><idno type="ArticleID">ANA22321</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Independent and joint effects of the <italic>MAPT</italic> and <italic>SNCA</italic> genes in Parkinson's disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A4"> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neurology; St Olav Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Neurology; St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A7"> Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><nlm:aff id="A8"> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A14"> Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="A21"> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><nlm:aff id="A22"> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06</wicri:regionArea><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris Descartes, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A24"> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15</wicri:regionArea><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A25"> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="1"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21391235</idno><idno type="pmc">3082599</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082599</idno><idno type="RBID">PMC:3082599</idno><idno type="doi">10.1002/ana.22321</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000415</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000415</idno><idno type="wicri:Area/Pmc/Curation">000415</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000415</idno><idno type="wicri:Area/Pmc/Checkpoint">000936</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000936</idno><idno type="wicri:Area/Ncbi/Merge">000E38</idno><idno type="wicri:Area/Ncbi/Curation">000E38</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E38</idno><idno type="wicri:doubleKey">0364-5134:2011:Elbaz A:independent:and:joint</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Independent and joint effects of the <italic>MAPT</italic> and <italic>SNCA</italic> genes in Parkinson's disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A4"> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea><wicri:noRegion>Ioannina</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neurology; St Olav Hospital, Trondheim, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea> Department of Neurology; St Olav Hospital, Trondheim</wicri:regionArea><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation wicri:level="1"><nlm:aff id="A7"> Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation wicri:level="1"><nlm:aff id="A8"> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><nlm:aff id="A14"> Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="3"><nlm:aff id="A21"> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion><wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion></affiliation></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation wicri:level="1"><nlm:aff id="A22"> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06</wicri:regionArea><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion><wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Université Paris Descartes, F-75005, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A24"> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15</wicri:regionArea><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion><wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><nlm:aff id="A25"> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea><wicri:noRegion>University College Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea><wicri:noRegion>59045, Lille</wicri:noRegion><wicri:noRegion>59045, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea><wicri:noRegion>59000, Lille</wicri:noRegion><wicri:noRegion>59000, Lille</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea><wicri:noRegion>59037, Lille</wicri:noRegion><wicri:noRegion>59037, Lille</wicri:noRegion></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea><wicri:noRegion>Katowice</wicri:noRegion></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea><wicri:noRegion>Lund University</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea><wicri:noRegion>Germaneto</wicri:noRegion></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea><wicri:noRegion>University of Athens Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea><wicri:noRegion>San Giovanni Rotondo</wicri:noRegion></affiliation></author><author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><wicri:noRegion>FL</wicri:noRegion></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea><wicri:noRegion>Larissa</wicri:noRegion></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation wicri:level="1"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea><wicri:noRegion>IL</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea><wicri:noRegion>V5Z4H4 BC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">We studied the independent and joint effects of the genes encoding alpha-synuclein (<italic>SNCA</italic>) and microtubule associated protein tau (<italic>MAPT</italic>) in Parkinson's disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">Participants of Caucasian ancestry were genotyped for a total of four <italic>SNCA</italic> (rs2583988, rs181489, rs356219, rs11931074) and two <italic>MAPT</italic> (rs1052553, rs242557) SNPs. Individual and joint effects of <italic>SNCA</italic> and <italic>MAPT</italic> SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied both on a multiplicative and an additive scale, and using a case-control and case-only approach.</p></sec><sec id="S3"><title>Results</title><p id="P3">Fifteen GEO-PD sites contributed a total of 5302 cases and 4161 controls. All four <italic>SNCA</italic> SNPs and the <italic>MAPT</italic> H1-haplotype defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For <italic>SNCA</italic>, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the four <italic>SNCA</italic> SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</p></sec><sec id="S4"><title>Interpretation</title><p id="P4">This study confirms the association between PD and both <italic>SNCA</italic> SNPs and the H1 <italic>MAPT</italic> haplotype. It shows, based on a variety of approaches, that the joint action of variants in these two loci is consistent with independent effects of the genes without additional interacting effects.</p></sec></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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