Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Identifieur interne : 001865 ( Istex/Corpus ); précédent : 001864; suivant : 001866Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
Auteurs : Alexis Elbaz ; Owen A. Ross ; John P. A. Ioannidis ; Alexandra I. Soto-Ortolaza ; Frédéric Moisan ; Jan Aasly ; Grazia Annesi ; Maria Bozi ; Laura Brighina ; Marie-Christine Chartier-Harlin ; Alain Destée ; Carlo Ferrarese ; Alessandro Ferraris ; J. Mark Gibson ; Suzana Gispert ; Georgios M. Hadjigeorgiou ; Barbara Jasinska-Myga ; Christine Klein ; Rejko Krüger ; Jean-Charles Lambert ; Katja Lohmann ; Simone Van De Loo ; Marie-Anne Loriot ; Timothy Lynch ; George D. Mellick ; Eugénie Mutez ; Christer Nilsson ; Grzegorz Opala ; Andreas Puschmann ; Aldo Quattrone ; Manu Sharma ; Peter A. Silburn ; Leonidas Stefanis ; Ryan J. Uitti ; Enza Maria Valente ; Carles Vilari O-Güell ; Karin Wirdefeldt ; Zbigniew K. Wszolek ; Georgia Xiromerisiou ; Demetrius M. Maraganore ; Matthew J. FarrerSource :
- Annals of Neurology [ 0364-5134 ] ; 2011-05.
Abstract
We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.
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DOI: 10.1002/ana.22321
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><mods:affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation><mods:affiliation>Department of Neurology, St Olav Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><mods:affiliation>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><mods:affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation><mods:affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Paris Descartes, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><mods:affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/ana.22321</idno><idno type="url">https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001865</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001865</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation><mods:affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</mods:affiliation></affiliation></author><author><name sortKey="Soto Rtolaza, Alexandra I" sort="Soto Rtolaza, Alexandra I" uniqKey="Soto Rtolaza A" first="Alexandra I." last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation><mods:affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name><affiliation><mods:affiliation>Department of Neurology, St Olav Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name><affiliation><mods:affiliation>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name><affiliation><mods:affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name><affiliation><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lambert, Jean Harles" sort="Lambert, Jean Harles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><mods:affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation><mods:affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name><affiliation><mods:affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</mods:affiliation></affiliation></author><author><name sortKey="Loriot, Marie Nne" sort="Loriot, Marie Nne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name><affiliation><mods:affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Paris Descartes, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name><affiliation><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation></author><author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name><affiliation><mods:affiliation>UMR 837 INSERM, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Univ Lille Nord de France, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>University Hospital, CHRU, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name><affiliation><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name><affiliation><mods:affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</mods:affiliation></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name><affiliation><mods:affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name><affiliation><mods:affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name><affiliation><mods:affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</mods:affiliation></affiliation></author><author><name sortKey="Vilari O Ell, Carles" sort="Vilari O Ell, Carles" uniqKey="Vilari O Ell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation><mods:affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><idno type="DOI">10.1002/ana.22321</idno><idno type="ArticleID">ANA22321</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Alexis Elbaz MD, PhD</name><affiliations><json:string>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</json:string><json:string>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</json:string><json:string>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</json:string></affiliations></json:item><json:item><name>Owen A. Ross PhD</name><affiliations><json:string>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</json:string></affiliations></json:item><json:item><name>John P. A. Ioannidis MD, PhD</name><affiliations><json:string>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</json:string><json:string>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</json:string></affiliations></json:item><json:item><name>Alexandra I. Soto‐Ortolaza BSc</name><affiliations><json:string>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</json:string></affiliations></json:item><json:item><name>Frédéric Moisan MSc</name><affiliations><json:string>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</json:string><json:string>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</json:string></affiliations></json:item><json:item><name>Jan Aasly MD</name><affiliations><json:string>Department of Neurology, St Olav Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>Grazia Annesi PhD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</json:string></affiliations></json:item><json:item><name>Maria Bozi MD</name><affiliations><json:string>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</json:string></affiliations></json:item><json:item><name>Laura Brighina MD, PhD</name><affiliations><json:string>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</json:string></affiliations></json:item><json:item><name>Marie‐Christine Chartier‐Harlin PhD</name><affiliations><json:string>UMR 837 INSERM, Lille, France</json:string><json:string>Univ Lille Nord de France, Lille, France</json:string></affiliations></json:item><json:item><name>Alain Destée MD, PhD</name><affiliations><json:string>UMR 837 INSERM, Lille, France</json:string><json:string>Univ Lille Nord de France, Lille, France</json:string><json:string>University Hospital, CHRU, Lille, France</json:string></affiliations></json:item><json:item><name>Carlo Ferrarese MD, PhD</name><affiliations><json:string>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</json:string></affiliations></json:item><json:item><name>Alessandro Ferraris MD, PhD</name><affiliations><json:string>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</json:string></affiliations></json:item><json:item><name>J. Mark Gibson MD</name><affiliations><json:string>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</json:string></affiliations></json:item><json:item><name>Suzana Gispert PhD</name><affiliations><json:string>Department of Neurology, Goethe University, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Georgios M. Hadjigeorgiou MD</name><affiliations><json:string>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</json:string><json:string>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</json:string></affiliations></json:item><json:item><name>Barbara Jasinska‐Myga MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string></affiliations></json:item><json:item><name>Christine Klein MD</name><affiliations><json:string>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</json:string></affiliations></json:item><json:item><name>Rejko Krüger MD, PhD</name><affiliations><json:string>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Jean‐Charles Lambert PhD</name><affiliations><json:string>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</json:string></affiliations></json:item><json:item><name>Katja Lohmann PhD</name><affiliations><json:string>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</json:string></affiliations></json:item><json:item><name>Simone van de Loo MD</name><affiliations><json:string>Department of Neurology, Goethe University, Frankfurt am Main, Germany</json:string></affiliations></json:item><json:item><name>Marie‐Anne Loriot PharmD, PhD</name><affiliations><json:string>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</json:string><json:string>University Paris Descartes, Paris, France</json:string><json:string>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</json:string></affiliations></json:item><json:item><name>Timothy Lynch MD</name><affiliations><json:string>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</json:string></affiliations></json:item><json:item><name>George D. Mellick MD, PhD</name><affiliations><json:string>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</json:string><json:string>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</json:string><json:string>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</json:string></affiliations></json:item><json:item><name>Eugénie Mutez MD</name><affiliations><json:string>UMR 837 INSERM, Lille, France</json:string><json:string>Univ Lille Nord de France, Lille, France</json:string><json:string>University Hospital, CHRU, Lille, France</json:string></affiliations></json:item><json:item><name>Christer Nilsson MD, PhD</name><affiliations><json:string>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Grzegorz Opala MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string></affiliations></json:item><json:item><name>Andreas Puschmann MD</name><affiliations><json:string>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</json:string><json:string>Department of Neurology, Skåne University Hospital, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Aldo Quattrone MD</name><affiliations><json:string>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</json:string></affiliations></json:item><json:item><name>Manu Sharma PhD</name><affiliations><json:string>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Peter A. Silburn MD, PhD</name><affiliations><json:string>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</json:string><json:string>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</json:string><json:string>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</json:string><json:string>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</json:string></affiliations></json:item><json:item><name>Leonidas Stefanis MD, PhD</name><affiliations><json:string>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</json:string></affiliations></json:item><json:item><name>Ryan J. Uitti MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, FL</json:string></affiliations></json:item><json:item><name>Enza Maria Valente MD, PhD</name><affiliations><json:string>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</json:string></affiliations></json:item><json:item><name>Carles Vilariño‐Güell PhD</name><affiliations><json:string>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</json:string><json:string>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item><json:item><name>Karin Wirdefeldt MD, PhD</name><affiliations><json:string>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Zbigniew K. Wszolek MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, FL</json:string></affiliations></json:item><json:item><name>Georgia Xiromerisiou MD</name><affiliations><json:string>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</json:string><json:string>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</json:string></affiliations></json:item><json:item><name>Demetrius M. Maraganore MD</name><affiliations><json:string>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</json:string></affiliations></json:item><json:item><name>Matthew J. Farrer PhD</name><affiliations><json:string>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</json:string><json:string>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</json:string></affiliations></json:item></author><articleId><json:string>ANA22321</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>5.528</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 801 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>325</abstractCharCount><pdfWordCount>6791</pdfWordCount><pdfCharCount>48683</pdfCharCount><pdfPageCount>15</pdfPageCount><abstractWordCount>44</abstractWordCount></qualityIndicators><title>Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><corporate><json:item><name>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium</name></json:item></corporate><genre><json:string>article</json:string></genre><host><title>Annals of Neurology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8249</json:string></doi><issn><json:string>0364-5134</json:string></issn><eissn><json:string>1531-8249</json:string></eissn><publisherId><json:string>ANA</json:string></publisherId><volume>69</volume><issue>5</issue><pages><first>778</first><last>792</last><total>15</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/ana.22321</json:string></doi><id>E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</id><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2011 American Neurological Association</p></availability><date>2011</date></publicationStmt><notesStmt><note>GEO‐PD (Genetic Epidemiology of Parkinson's Disease) collaborators and funding sources. France</note><note>Philippe Amouyel (INSERM, U744, Lille, France)</note><note>Christophe Tzourio (INSERM, U708, Paris, France)</note><note>Claire Mulot (INSERM, U775; CRB Epigenetec, Paris, France)</note><note>National Research Agency (ANR; Environment and Health SEST 2005; Neurological Diseases MNP 2009)</note><note>French Agency for Environmental and Occupational Health Safety (Afsset)</note><note>France Parkinson</note><note>USA: Justin A. Bacon and Stephanie A. Cobb (Mayo Clinic, Jacksonville)</note><note>Michael J. Fox Foundation</note><note>American Parkinson's Disease Association Research Grant</note><note>Mayo Clinic Jacksonville is a Morris K. Udall Parkinson's Disease Research Center of Excellence (National Institute of Neurological Disorders and Stroke [NINDS] P50 #NS40256)</note><note>National Institutes of Health (NIH) - No. 2R01ES10751;</note><note>Greece/USA: Funding: Scientific support for this project to J.P.A.I. was provided through the Tufts Clinical and Translational Science Institute (Tufts CTSI) under funding from the NIH/National Center for Research Resources - No. (UL1 RR025752; principal investigator: Harry Selker);</note><note>National Health and Medical Research Council (Australia) - No. #401537;</note><note>Geriatric Medical Foundation of Queensland</note><note>Princess Alexandra Hospital</note><note>Royal Brisbane and Women's Hospital Foundations</note><note>France (site B): Florence Pasquier and Régis Bordet (Steering Committee of the Paradigm Study)</note><note>Jean‐Philippe Legendre (CHRU‐Lille)</note><note>Foundation for Medical Research (FRM; Convergence 2006/413)</note><note>PHRC (Parkfanord 005/1913, Paradigme 2002/1918)</note><note>University of Lille 2 (Synucleothèque)</note><note>INSERM‐French Research Ministry for support for the biological resources centers (CHRU Lille</note><note>Institut Pasteur de Lille)</note><note>Germany (site C): Georg Auburger</note><note>Rüdiger Hilker</note><note>Nadine Abahuni (Goethe University Frankfurt)</note><note>Christof Geisen (Blood Bank Frankfurt)</note><note>BMBF NGFNplus - No. 01GS08138;</note><note>Germany (site D): Susen Winkler</note><note>Volkswagen Foundation</note><note>Hermann and Lilly Schilling Foundation</note><note>Germany (site E): Thomas Gasser, Olaf Riess, Daniela Berg, Claudia Schulte</note><note>German Research Council - No. [DFG, KR2119/3‐2];</note><note>Federal Ministry for Education and Research (BMBF, NGFNplus - No. 01GS08134;</note><note>Michael J. Fox Foundation</note><note>Greece (site F): Demitris Vassilatis</note><note>Eleftherios Stamboulis</note><note>Hellenic Secretariat of Research and Technology - No. ΠηνηΔ 2003;</note><note>Greece (site G): Efthimios Dardiotis (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note>Ioanna Patramani (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note>Persa‐Maria Kountra (Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note>Christina Vogiatzi (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note>Katerina Markou (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note>University of Thessaly, Research Committee - No. code: 2845;</note><note>Institute of Biomedical Research and Technology, CERETETH - No. code: 01‐04‐207;</note><note>Italy (site I): Patrizia Tarantino, Ferdinanda Annesi (Institute of Neurological Sciences, National Research Council, Cosenza, Italy)</note><note>Italy (site J): Anna Rita Bentivoglio, Arianna Guidubaldi, Matilde Caccialupi, Francesca De Nigris (Institute of Neurology, Catholic University, Rome, Italy)</note><note>Italian Ministry of Health (Ricerca Corrente 2010</note><note>Ricerca Finalizzata 2006</note><note>Progetto Giovani Ricercatori 2008)</note><note>Italy (site K): Chiara Riva (Department of Neuroscience and Biomedical Technologies, University of Milano‐Bicocca, Monza, Italy)</note><note>FIRB 2003 GENOPOLIS Project - No. RBLA038RMA_003;</note><note>Norway (site L):</note><note>Research Council of Norway - No. project 10314000;</note><note>Sweden (site N): Nancy L. Pedersen</note><note>NIH - No. ES10758;</note><note>Swedish Research Council, Swedish Society for Medical Research, Swedish Society of Medicine, Karolinska Institutet, and Parkinson Foundation in Sweden</note><note>Sweden (site P): Karin Nilsson (Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden)</note><note>Jan Reimer (Department of Neurology, Skåne University Hospital, Lund, Sweden</note><note>Region Skåne Competence Center, Skåne University Hospital, Malmö, Sweden)</note><note>Swedish Parkinson Academy</note><note>AFA Insurance Research Grant</note><note>Elsa Schmitz Foundation</note><note>Apotekare Hedberg's Foundation for Medical Research</note><note>Swedish Parkinson Fund</note><note>Royal Physiographic Society in Lund, Lund University Hospital Research Fund</note><note>USA (site O): Jay Van Gerpen, Jennifer Lash, Jill Searcy, Audrey Strongosky</note><note>Mayo Clinic Jacksonville, Morris K. Udall Parkinson's Disease Research Center of Excellence</note><note>NIH/NINDS - No. P50 #NS40256;</note><note>NIH/NINDS - No. R01 NS057567;</note><note>NIH/NINDS - No. RC2 NS070276‐01;</note><note>Mayo Clinic Florida Research Committee CR programs</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title><author><orgName>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium</orgName></author><author xml:id="author-1"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</affiliation><affiliation>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Owen A.</forename><surname>Ross</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation></author><author xml:id="author-3"><persName><forename type="first">John P. A.</forename><surname>Ioannidis</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</affiliation><affiliation>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</affiliation></author><author xml:id="author-4"><persName><forename type="first">Alexandra I.</forename><surname>Soto‐Ortolaza</surname></persName><roleName type="degree">BSc</roleName><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation></author><author xml:id="author-5"><persName><forename type="first">Frédéric</forename><surname>Moisan</surname></persName><roleName type="degree">MSc</roleName><affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Jan</forename><surname>Aasly</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, St Olav Hospital, Trondheim, Norway</affiliation></author><author xml:id="author-7"><persName><forename type="first">Grazia</forename><surname>Annesi</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</affiliation></author><author xml:id="author-8"><persName><forename type="first">Maria</forename><surname>Bozi</surname></persName><roleName type="degree">MD</roleName><affiliation>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</affiliation></author><author xml:id="author-9"><persName><forename type="first">Laura</forename><surname>Brighina</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation></author><author xml:id="author-10"><persName><forename type="first">Marie‐Christine</forename><surname>Chartier‐Harlin</surname></persName><roleName type="degree">PhD</roleName><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation></author><author xml:id="author-11"><persName><forename type="first">Alain</forename><surname>Destée</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation><affiliation>University Hospital, CHRU, Lille, France</affiliation></author><author xml:id="author-12"><persName><forename type="first">Carlo</forename><surname>Ferrarese</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation></author><author xml:id="author-13"><persName><forename type="first">Alessandro</forename><surname>Ferraris</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</affiliation></author><author xml:id="author-14"><persName><forename type="first">J. Mark</forename><surname>Gibson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation></author><author xml:id="author-15"><persName><forename type="first">Suzana</forename><surname>Gispert</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-16"><persName><forename type="first">Georgios M.</forename><surname>Hadjigeorgiou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</affiliation></author><author xml:id="author-17"><persName><forename type="first">Barbara</forename><surname>Jasinska‐Myga</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation></author><author xml:id="author-18"><persName><forename type="first">Christine</forename><surname>Klein</surname></persName><roleName type="degree">MD</roleName><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</affiliation></author><author xml:id="author-19"><persName><forename type="first">Rejko</forename><surname>Krüger</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</affiliation></author><author xml:id="author-20"><persName><forename type="first">Jean‐Charles</forename><surname>Lambert</surname></persName><roleName type="degree">PhD</roleName><affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</affiliation></author><author xml:id="author-21"><persName><forename type="first">Katja</forename><surname>Lohmann</surname></persName><roleName type="degree">PhD</roleName><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</affiliation></author><author xml:id="author-22"><persName><forename type="first">Simone</forename><surname>van de Loo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation></author><author xml:id="author-23"><persName><forename type="first">Marie‐Anne</forename><surname>Loriot</surname></persName><roleName type="degree">PharmD, PhD</roleName><affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</affiliation><affiliation>University Paris Descartes, Paris, France</affiliation><affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</affiliation></author><author xml:id="author-24"><persName><forename type="first">Timothy</forename><surname>Lynch</surname></persName><roleName type="degree">MD</roleName><affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</affiliation></author><author xml:id="author-25"><persName><forename type="first">George D.</forename><surname>Mellick</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</affiliation><affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</affiliation></author><author xml:id="author-26"><persName><forename type="first">Eugénie</forename><surname>Mutez</surname></persName><roleName type="degree">MD</roleName><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation><affiliation>University Hospital, CHRU, Lille, France</affiliation></author><author xml:id="author-27"><persName><forename type="first">Christer</forename><surname>Nilsson</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</affiliation></author><author xml:id="author-28"><persName><forename type="first">Grzegorz</forename><surname>Opala</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation></author><author xml:id="author-29"><persName><forename type="first">Andreas</forename><surname>Puschmann</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</affiliation><affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</affiliation></author><author xml:id="author-30"><persName><forename type="first">Aldo</forename><surname>Quattrone</surname></persName><roleName type="degree">MD</roleName><affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</affiliation></author><author xml:id="author-31"><persName><forename type="first">Manu</forename><surname>Sharma</surname></persName><roleName type="degree">PhD</roleName><affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</affiliation></author><author xml:id="author-32"><persName><forename type="first">Peter A.</forename><surname>Silburn</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</affiliation><affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</affiliation></author><author xml:id="author-33"><persName><forename type="first">Leonidas</forename><surname>Stefanis</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</affiliation></author><author xml:id="author-34"><persName><forename type="first">Ryan J.</forename><surname>Uitti</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</affiliation></author><author xml:id="author-35"><persName><forename type="first">Enza Maria</forename><surname>Valente</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</affiliation></author><author xml:id="author-36"><persName><forename type="first">Carles</forename><surname>Vilariño‐Güell</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author><author xml:id="author-37"><persName><forename type="first">Karin</forename><surname>Wirdefeldt</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</affiliation></author><author xml:id="author-38"><persName><forename type="first">Zbigniew K.</forename><surname>Wszolek</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</affiliation></author><author xml:id="author-39"><persName><forename type="first">Georgia</forename><surname>Xiromerisiou</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</affiliation></author><author xml:id="author-40"><persName><forename type="first">Demetrius M.</forename><surname>Maraganore</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</affiliation></author><author xml:id="author-41"><persName><forename type="first">Matthew J.</forename><surname>Farrer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</affiliation></author></analytic><monogr><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="pISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><idno type="DOI">10.1002/(ISSN)1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-05"></date><biblScope unit="volume">69</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="778">778</biblScope><biblScope unit="page" to="792">792</biblScope></imprint></monogr><idno type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</idno><idno type="DOI">10.1002/ana.22321</idno><idno type="ArticleID">ANA22321</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</p></abstract><abstract><p>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed‐ and random‐effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case–control and case‐only approach.</p></abstract><abstract><p>Fifteen GEO‐PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1‐haplotype–defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</p></abstract><abstract><p>This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Original Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-05-21">Received</change><change when="2010-10-22">Registration</change><change when="2011-05">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api-v5.istex.fr/document/E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8249</doi><issn type="print">0364-5134</issn><issn type="electronic">1531-8249</issn><idGroup><id type="product" value="ANA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="ANNALS OF NEUROLOGY">Annals of Neurology</title><title type="short">Ann Neurol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/ana.v69.5</doi><numberingGroup><numbering type="journalVolume" number="69">69</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2011-05">May 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ana.22321</doi><idGroup><id type="unit" value="ANA22321"></id></idGroup><countGroup><count type="pageTotal" number="15"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2011 American Neurological Association</copyright><eventGroup><event type="manuscriptReceived" date="2010-05-21"></event><event type="manuscriptRevised" date="2010-10-18"></event><event type="manuscriptAccepted" date="2010-10-22"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.8 mode:FullText" date="2011-04-22"></event><event type="publishedOnlineAccepted" date="2010-10-29"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-03-09"></event><event type="firstOnline" date="2011-03-09"></event><event type="publishedOnlineFinalForm" date="2011-04-22"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-03"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">778</numbering><numbering type="pageLast">792</numbering></numberingGroup><correspondenceTo>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANA.ANA22321.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="47"></count><count type="wordTotal" number="13472"></count></countGroup><titleGroup><title type="main" xml:lang="en">Independent and joint effects of the <i>MAPT</i> and <i>SNCA</i> genes in Parkinson disease</title><title type="short" xml:lang="en"><fi>MAPT</fi> and <fi>SNCA</fi> in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Alexis</givenNames><familyName>Elbaz</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>alexis.elbaz@upmc.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Owen A.</givenNames><familyName>Ross</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af4 #af5"><personName><givenNames>John P. 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Udall Parkinson's Disease Research Center of Excellence (National Institute of Neurological Disorders and Stroke [NINDS] P50 #NS40256)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>National Institutes of Health (NIH)</fundingAgency><fundingNumber>2R01ES10751</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Greece/USA: Funding: Scientific support for this project to J.P.A.I. was provided through the Tufts Clinical and Translational Science Institute (Tufts CTSI) under funding from the NIH/National Center for Research Resources</fundingAgency><fundingNumber>(UL1 RR025752; principal investigator: Harry Selker)</fundingNumber></fundingInfo><fundingInfo><fundingAgency>National Health and Medical Research Council (Australia)</fundingAgency><fundingNumber>#401537</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Geriatric Medical Foundation of Queensland</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Princess Alexandra Hospital</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Royal Brisbane and Women's Hospital Foundations</fundingAgency></fundingInfo><fundingInfo><fundingAgency>France (site B): Florence Pasquier and Régis Bordet (Steering Committee of the Paradigm Study)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Jean‐Philippe Legendre (CHRU‐Lille)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Foundation for Medical Research (FRM; Convergence 2006/413)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>PHRC (Parkfanord 005/1913, Paradigme 2002/1918)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>University of Lille 2 (Synucleothèque)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>INSERM‐French Research Ministry for support for the biological resources centers (CHRU Lille</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Institut Pasteur de Lille)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Germany (site C): Georg Auburger</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Rüdiger Hilker</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Nadine Abahuni (Goethe University Frankfurt)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Christof Geisen (Blood Bank Frankfurt)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>BMBF NGFNplus</fundingAgency><fundingNumber>01GS08138</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Germany (site D): Susen Winkler</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Volkswagen Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Hermann and Lilly Schilling Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Germany (site E): Thomas Gasser, Olaf Riess, Daniela Berg, Claudia Schulte</fundingAgency></fundingInfo><fundingInfo><fundingAgency>German Research Council</fundingAgency><fundingNumber>[DFG, KR2119/3‐2]</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Federal Ministry for Education and Research (BMBF, NGFNplus</fundingAgency><fundingNumber>01GS08134</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Michael J. Fox Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Greece (site F): Demitris Vassilatis</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Eleftherios Stamboulis</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Hellenic Secretariat of Research and Technology</fundingAgency><fundingNumber>ΠηνηΔ 2003</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Greece (site G): Efthimios Dardiotis (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ioanna Patramani (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Persa‐Maria Kountra (Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Christina Vogiatzi (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Katerina Markou (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>University of Thessaly, Research Committee</fundingAgency><fundingNumber>code: 2845</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Institute of Biomedical Research and Technology, CERETETH</fundingAgency><fundingNumber>code: 01‐04‐207</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Italy (site I): Patrizia Tarantino, Ferdinanda Annesi (Institute of Neurological Sciences, National Research Council, Cosenza, Italy)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Italy (site J): Anna Rita Bentivoglio, Arianna Guidubaldi, Matilde Caccialupi, Francesca De Nigris (Institute of Neurology, Catholic University, Rome, Italy)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Italian Ministry of Health (Ricerca Corrente 2010</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ricerca Finalizzata 2006</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Progetto Giovani Ricercatori 2008)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Italy (site K): Chiara Riva (Department of Neuroscience and Biomedical Technologies, University of Milano‐Bicocca, Monza, Italy)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>FIRB 2003 GENOPOLIS Project</fundingAgency><fundingNumber>RBLA038RMA_003</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Norway (site L):</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Research Council of Norway</fundingAgency><fundingNumber>project 10314000</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Sweden (site N): Nancy L. Pedersen</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIH</fundingAgency><fundingNumber>ES10758</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Swedish Research Council, Swedish Society for Medical Research, Swedish Society of Medicine, Karolinska Institutet, and Parkinson Foundation in Sweden</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Sweden (site P): Karin Nilsson (Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Jan Reimer (Department of Neurology, Skåne University Hospital, Lund, Sweden</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Region Skåne Competence Center, Skåne University Hospital, Malmö, Sweden)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Swedish Parkinson Academy</fundingAgency></fundingInfo><fundingInfo><fundingAgency>AFA Insurance Research Grant</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Elsa Schmitz Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Apotekare Hedberg's Foundation for Medical Research</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Swedish Parkinson Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Royal Physiographic Society in Lund, Lund University Hospital Research Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>USA (site O): Jay Van Gerpen, Jennifer Lash, Jill Searcy, Audrey Strongosky</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Mayo Clinic Jacksonville, Morris K. Udall Parkinson's Disease Research Center of Excellence</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NIH/NINDS</fundingAgency><fundingNumber>P50 #NS40256</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIH/NINDS</fundingAgency><fundingNumber>R01 NS057567</fundingNumber></fundingInfo><fundingInfo><fundingAgency>NIH/NINDS</fundingAgency><fundingNumber>RC2 NS070276‐01</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Mayo Clinic Florida Research Committee CR programs</fundingAgency></fundingInfo><supportingInformation><p> Additional supporting information can be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:03645134:media:ana22321:ANA_22321_sm_suppinfo"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Objective:</title><p>We studied the independent and joint effects of the genes encoding alpha‐synuclein (<i>SNCA</i>) and microtubule‐associated protein tau (<i>MAPT</i>) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Participants of Caucasian ancestry were genotyped for a total of 4 <i>SNCA</i> (rs2583988, rs181489, rs356219, rs11931074) and 2 <i>MAPT</i> (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of <i>SNCA</i> and <i>MAPT</i> SNPs were investigated using fixed‐ and random‐effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case–control and case‐only approach.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>Fifteen GEO‐PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 <i>SNCA</i> SNPs and the <i>MAPT</i> H1‐haplotype–defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For <i>SNCA</i>, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the 4 <i>SNCA</i> SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</p></section><section xml:id="abs1-4"><title type="main">Interpretation:</title><p>This study confirms the association between PD and both <i>SNCA</i> SNPs and the H1 <i>MAPT</i> haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>MAPT and SNCA in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Independent and joint effects of the MAPT and SNCA genes in Parkinson disease</title></titleInfo><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Elbaz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</affiliation><affiliation>INSERM U708, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Owen A.</namePart><namePart type="family">Ross</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John P. A.</namePart><namePart type="family">Ioannidis</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</affiliation><affiliation>Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandra I.</namePart><namePart type="family">Soto‐Ortolaza</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frédéric</namePart><namePart type="family">Moisan</namePart><namePart type="termsOfAddress">MSc</namePart><affiliation>INSERM, U708, Neuroepidemiology, F‐75013, Paris, France</affiliation><affiliation>UPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Aasly</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, St Olav Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grazia</namePart><namePart type="family">Annesi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Cosenza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maria</namePart><namePart type="family">Bozi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Brighina</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Christine</namePart><namePart type="family">Chartier‐Harlin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Destée</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation><affiliation>University Hospital, CHRU, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Ferrarese</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alessandro</namePart><namePart type="family">Ferraris</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. Mark</namePart><namePart type="family">Gibson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suzana</namePart><namePart type="family">Gispert</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georgios M.</namePart><namePart type="family">Hadjigeorgiou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Jasinska‐Myga</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Klein</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rejko</namePart><namePart type="family">Krüger</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Charles</namePart><namePart type="family">Lambert</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katja</namePart><namePart type="family">Lohmann</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Simone</namePart><namePart type="family">van de Loo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Goethe University, Frankfurt am Main, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Anne</namePart><namePart type="family">Loriot</namePart><namePart type="termsOfAddress">PharmD, PhD</namePart><affiliation>INSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, France</affiliation><affiliation>University Paris Descartes, Paris, France</affiliation><affiliation>Assistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy</namePart><namePart type="family">Lynch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George D.</namePart><namePart type="family">Mellick</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</affiliation><affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugénie</namePart><namePart type="family">Mutez</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>UMR 837 INSERM, Lille, France</affiliation><affiliation>Univ Lille Nord de France, Lille, France</affiliation><affiliation>University Hospital, CHRU, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christer</namePart><namePart type="family">Nilsson</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grzegorz</namePart><namePart type="family">Opala</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Puschmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden</affiliation><affiliation>Department of Neurology, Skåne University Hospital, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Aldo</namePart><namePart type="family">Quattrone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Manu</namePart><namePart type="family">Sharma</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter A.</namePart><namePart type="family">Silburn</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</affiliation><affiliation>Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</affiliation><affiliation>School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leonidas</namePart><namePart type="family">Stefanis</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ryan J.</namePart><namePart type="family">Uitti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Enza Maria</namePart><namePart type="family">Valente</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Mendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carles</namePart><namePart type="family">Vilariño‐Güell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karin</namePart><namePart type="family">Wirdefeldt</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zbigniew K.</namePart><namePart type="family">Wszolek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georgia</namePart><namePart type="family">Xiromerisiou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</affiliation><affiliation>Institute of Biomedical Research and Technology, CERETETH, Larissa, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetrius M.</namePart><namePart type="family">Maraganore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, NorthShore University HealthSystem, Evanston, IL</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthew J.</namePart><namePart type="family">Farrer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL</affiliation><affiliation>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium</namePart><description>INSERM, U708, Neuroepidemiology, F‐75013, Paris, FranceUPMC Univ Paris 06, UMR_S708, Neuroepidemiology, F‐75005, Paris, FranceDivision of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FLClinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, GreeceTufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, MADepartment of Neurology, St Olav Hospital, Trondheim, NorwayInstitute of Neurological Sciences, National Research Council, Cosenza, ItalyGeneral Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Athens, GreeceDepartment of Neurology and Neuroscience, University of Milano‐Bicocca, San Gerardo Hospital, Monza, ItalyUMR 837 INSERM, Lille, FranceUniv Lille Nord de France, Lille, FranceUniversity Hospital, CHRU, Lille, FranceMendel Laboratory IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, ItalyDepartment of Neurology, Royal Victoria Hospital, Belfast, IrelandDepartment of Neurology, Goethe University, Frankfurt am Main, GermanyDepartment of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, GreeceInstitute of Biomedical Research and Technology, CERETETH, Larissa, GreeceDepartment of Neurology, Medical University of Silesia, Katowice, PolandSection of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Lübeck, Lübeck, GermanyCenter of Neurology and Hertie‐Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases, Tübingen, GermanyINSERM, U744, Pasteur Institute from Lille, University of Lille‐Nord de France, Lille, FranceINSERM, UMR‐S 775, Molecular basis of response to xenobiotics, Paris, FranceUniversity Paris Descartes, Paris, FranceAssistance‐Publique Hôpitaux de Paris, Georges Pompidou European Hospital (HEGP), Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Paris, FranceDublin Neurological Institute at the Mater Misericordiae University Hospital and Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, IrelandNational Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, AustraliaDepartment of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, AustraliaNeurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, AustraliaDepartment of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, SwedenDepartment of Neurology, Skåne University Hospital, Lund, SwedenInstitute of Neurology, University Magna Graecia, Catanzaro and Neuroimaging Research Unit, National Research Council, Germaneto, ItalySchool of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, AustraliaDivision of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens and Second Department of Neurology, University of Athens Medical School, Athens, GreeceDepartment of Neurology, Mayo Clinic, Jacksonville, FLDepartment of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Neurology, NorthShore University HealthSystem, Evanston, ILCentre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada</description></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2011-05</dateIssued><dateCaptured encoding="w3cdtf">2010-05-21</dateCaptured><dateValid encoding="w3cdtf">2010-10-22</dateValid><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">5</extent><extent unit="references">47</extent><extent unit="words">13472</extent></physicalDescription><abstract>We studied the independent and joint effects of the genes encoding alpha‐synuclein (SNCA) and microtubule‐associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta‐analysis of individual data from case–control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO‐PD) consortium.</abstract><abstract>Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed‐ and random‐effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case–control and case‐only approach.</abstract><abstract>Fifteen GEO‐PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1‐haplotype–defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</abstract><abstract>This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011</abstract><note type="funding">GEO‐PD (Genetic Epidemiology of Parkinson's Disease) collaborators and funding sources. France</note><note type="funding">Philippe Amouyel (INSERM, U744, Lille, France)</note><note type="funding">Christophe Tzourio (INSERM, U708, Paris, France)</note><note type="funding">Claire Mulot (INSERM, U775; CRB Epigenetec, Paris, France)</note><note type="funding">National Research Agency (ANR; Environment and Health SEST 2005; Neurological Diseases MNP 2009)</note><note type="funding">French Agency for Environmental and Occupational Health Safety (Afsset)</note><note type="funding">France Parkinson</note><note type="funding">USA: Justin A. Bacon and Stephanie A. Cobb (Mayo Clinic, Jacksonville)</note><note type="funding">Michael J. Fox Foundation</note><note type="funding">American Parkinson's Disease Association Research Grant</note><note type="funding">Mayo Clinic Jacksonville is a Morris K. Udall Parkinson's Disease Research Center of Excellence (National Institute of Neurological Disorders and Stroke [NINDS] P50 #NS40256)</note><note type="funding">National Institutes of Health (NIH) - No. 2R01ES10751; </note><note type="funding">Greece/USA: Funding: Scientific support for this project to J.P.A.I. was provided through the Tufts Clinical and Translational Science Institute (Tufts CTSI) under funding from the NIH/National Center for Research Resources - No. (UL1 RR025752; principal investigator: Harry Selker); </note><note type="funding">National Health and Medical Research Council (Australia) - No. #401537; </note><note type="funding">Geriatric Medical Foundation of Queensland</note><note type="funding">Princess Alexandra Hospital</note><note type="funding">Royal Brisbane and Women's Hospital Foundations</note><note type="funding">France (site B): Florence Pasquier and Régis Bordet (Steering Committee of the Paradigm Study)</note><note type="funding">Jean‐Philippe Legendre (CHRU‐Lille)</note><note type="funding">Foundation for Medical Research (FRM; Convergence 2006/413)</note><note type="funding">PHRC (Parkfanord 005/1913, Paradigme 2002/1918)</note><note type="funding">University of Lille 2 (Synucleothèque)</note><note type="funding">INSERM‐French Research Ministry for support for the biological resources centers (CHRU Lille</note><note type="funding">Institut Pasteur de Lille)</note><note type="funding">Germany (site C): Georg Auburger</note><note type="funding">Rüdiger Hilker</note><note type="funding">Nadine Abahuni (Goethe University Frankfurt)</note><note type="funding">Christof Geisen (Blood Bank Frankfurt)</note><note type="funding">BMBF NGFNplus - No. 01GS08138; </note><note type="funding">Germany (site D): Susen Winkler</note><note type="funding">Volkswagen Foundation</note><note type="funding">Hermann and Lilly Schilling Foundation</note><note type="funding">Germany (site E): Thomas Gasser, Olaf Riess, Daniela Berg, Claudia Schulte</note><note type="funding">German Research Council - No. [DFG, KR2119/3‐2]; </note><note type="funding">Federal Ministry for Education and Research (BMBF, NGFNplus - No. 01GS08134; </note><note type="funding">Michael J. Fox Foundation</note><note type="funding">Greece (site F): Demitris Vassilatis</note><note type="funding">Eleftherios Stamboulis</note><note type="funding">Hellenic Secretariat of Research and Technology - No. ΠηνηΔ 2003; </note><note type="funding">Greece (site G): Efthimios Dardiotis (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note type="funding">Ioanna Patramani (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note type="funding">Persa‐Maria Kountra (Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note type="funding">Christina Vogiatzi (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note type="funding">Katerina Markou (Department of Neurology, Faculty of Medicine, University of Thessaly, Larissa, Greece)</note><note type="funding">University of Thessaly, Research Committee - No. code: 2845; </note><note type="funding">Institute of Biomedical Research and Technology, CERETETH - No. code: 01‐04‐207; </note><note type="funding">Italy (site I): Patrizia Tarantino, Ferdinanda Annesi (Institute of Neurological Sciences, National Research Council, Cosenza, Italy)</note><note type="funding">Italy (site J): Anna Rita Bentivoglio, Arianna Guidubaldi, Matilde Caccialupi, Francesca De Nigris (Institute of Neurology, Catholic University, Rome, Italy)</note><note type="funding">Italian Ministry of Health (Ricerca Corrente 2010</note><note type="funding">Ricerca Finalizzata 2006</note><note type="funding">Progetto Giovani Ricercatori 2008)</note><note type="funding">Italy (site K): Chiara Riva (Department of Neuroscience and Biomedical Technologies, University of Milano‐Bicocca, Monza, Italy)</note><note type="funding">FIRB 2003 GENOPOLIS Project - No. RBLA038RMA_003; </note><note type="funding">Norway (site L):</note><note type="funding">Research Council of Norway - No. project 10314000; </note><note type="funding">Sweden (site N): Nancy L. Pedersen</note><note type="funding">NIH - No. ES10758; </note><note type="funding">Swedish Research Council, Swedish Society for Medical Research, Swedish Society of Medicine, Karolinska Institutet, and Parkinson Foundation in Sweden</note><note type="funding">Sweden (site P): Karin Nilsson (Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Lund, Sweden)</note><note type="funding">Jan Reimer (Department of Neurology, Skåne University Hospital, Lund, Sweden</note><note type="funding">Region Skåne Competence Center, Skåne University Hospital, Malmö, Sweden)</note><note type="funding">Swedish Parkinson Academy</note><note type="funding">AFA Insurance Research Grant</note><note type="funding">Elsa Schmitz Foundation</note><note type="funding">Apotekare Hedberg's Foundation for Medical Research</note><note type="funding">Swedish Parkinson Fund</note><note type="funding">Royal Physiographic Society in Lund, Lund University Hospital Research Fund</note><note type="funding">USA (site O): Jay Van Gerpen, Jennifer Lash, Jill Searcy, Audrey Strongosky</note><note type="funding">Mayo Clinic Jacksonville, Morris K. Udall Parkinson's Disease Research Center of Excellence</note><note type="funding">NIH/NINDS - No. P50 #NS40256; </note><note type="funding">NIH/NINDS - No. R01 NS057567; </note><note type="funding">NIH/NINDS - No. RC2 NS070276‐01; </note><note type="funding">Mayo Clinic Florida Research Committee CR programs</note><relatedItem type="host"><titleInfo><title>Annals of Neurology</title></titleInfo><titleInfo type="abbreviated"><title>Ann Neurol.</title></titleInfo><genre type="journal">journal</genre><note type="content"> Additional supporting information can be found in the online version of this article.Supporting Info Item: Supporting Information - </note><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0364-5134</identifier><identifier type="eISSN">1531-8249</identifier><identifier type="DOI">10.1002/(ISSN)1531-8249</identifier><identifier type="PublisherID">ANA</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>778</start><end>792</end><total>15</total></extent></part></relatedItem><identifier type="istex">E4A05E8C03AFAA6BA06C06A7DEAF7FC3992FC948</identifier><identifier type="DOI">10.1002/ana.22321</identifier><identifier type="ArticleID">ANA22321</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 American Neurological Association</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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