Independent and joint effects of the MAPT and SNCA genes in Parkinson's disease
Identifieur interne : 000E38 ( Ncbi/Checkpoint ); précédent : 000E37; suivant : 000E39Independent and joint effects of the MAPT and SNCA genes in Parkinson's disease
Auteurs : Alexis Elbaz [France] ; Owen A. Ross [États-Unis] ; John P. A. Ioannidis [Grèce, États-Unis] ; Alexandra I. Soto-Ortolaza [États-Unis] ; Frédéric Moisan [France] ; Jan Aasly [Norvège] ; Grazia Annesi [Italie] ; Maria Bozi [Grèce] ; Laura Brighina [Italie] ; Marie-Christine Chartier-Harlin [France] ; Alain Destée [France] ; Carlo Ferrarese [Italie] ; Alessandro Ferraris [Italie] ; J. Mark Gibson [Irlande (pays)] ; Suzana Gispert [Allemagne] ; Georgios M. Hadjigeorgiou [Grèce] ; Barbara Jasinska-Myga [Pologne] ; Christine Klein [Allemagne] ; Rejko Krüger [Allemagne] ; Jean-Charles Lambert [France] ; Katja Lohmann [Allemagne] ; Simone Van De Loo [Allemagne] ; Marie-Anne Loriot [France] ; Timothy Lynch [Irlande (pays)] ; George D. Mellick [Australie] ; Eugénie Mutez [France] ; Christer Nilsson [Suède] ; Grzegorz Opala [Pologne] ; Andreas Puschmann [Suède] ; Aldo Quattrone [Italie] ; Manu Sharma [Allemagne] ; Peter A. Silburn [Australie] ; Leonidas Stefanis [Grèce] ; Ryan J. Uitti [États-Unis] ; Enza Maria Valente [Italie] ; Carles Vilari O-Güell [États-Unis, Canada] ; Karin Wirdefeldt [Suède] ; Zbigniew K. Wszolek [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Demetrius M. Maraganore [États-Unis] ; Matthew J. Farrer [États-Unis, Canada]Source :
- Annals of neurology [ 0364-5134 ] ; 2011.
Abstract
We studied the independent and joint effects of the genes encoding alpha-synuclein (
Participants of Caucasian ancestry were genotyped for a total of four
Fifteen GEO-PD sites contributed a total of 5302 cases and 4161 controls. All four
This study confirms the association between PD and both
Url:
DOI: 10.1002/ana.22321
PubMed: 21391235
PubMed Central: 3082599
Affiliations:
- Allemagne, Australie, Canada, France, Grèce, Irlande (pays), Italie, Norvège, Pologne, Suède, États-Unis
- Bade-Wurtemberg, District de Tübingen, Floride, Hauts-de-France, Massachusetts, Nord-Pas-de-Calais, Svealand, Trøndelag, Île-de-France
- Lille, Paris, Stockholm, Trondheim, Tübingen
- Université Lille 2, Université Lille Nord de France, Université Paris-Descartes
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PMC:3082599Le document en format XML
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and <italic>SNCA</italic>
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<author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
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<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
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<affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
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<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
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<country xml:lang="fr">Pologne</country>
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<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
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<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
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<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
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<author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
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<author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
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<author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name>
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<affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff>
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<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
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<wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea>
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<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
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<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff>
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<author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea>
<wicri:noRegion>59045, Lille</wicri:noRegion>
<wicri:noRegion>59045, Lille</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea>
<wicri:noRegion>59000, Lille</wicri:noRegion>
<wicri:noRegion>59000, Lille</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea>
<wicri:noRegion>59037, Lille</wicri:noRegion>
<wicri:noRegion>59037, Lille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
<affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea>
<wicri:noRegion>Germaneto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name>
<affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
<affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="1"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z4H4 BC</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Independent and joint effects of the <italic>MAPT</italic>
and <italic>SNCA</italic>
genes in Parkinson's disease</title>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name>
<affiliation wicri:level="1"><nlm:aff id="A4"> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina</wicri:regionArea>
<wicri:noRegion>Ioannina</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5"> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Tufts Clinical and Translational Science Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name>
<affiliation wicri:level="3"><nlm:aff id="A1"> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM, Unit 708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A2"> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> UPMC Univ Paris 06, UMR-S 708, F-75005, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name>
<affiliation wicri:level="3"><nlm:aff id="A6"> Department of Neurology; St Olav Hospital, Trondheim, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea> Department of Neurology; St Olav Hospital, Trondheim</wicri:regionArea>
<placeName><settlement type="city">Trondheim</settlement>
<region type="région" nuts="2">Trøndelag</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
<affiliation wicri:level="1"><nlm:aff id="A7"> Institute of Neurological Sciences, National Research Council, Cosenza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Institute of Neurological Sciences, National Research Council, Cosenza</wicri:regionArea>
<wicri:noRegion>Cosenza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
<affiliation wicri:level="1"><nlm:aff id="A8"> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> General Hospital of Syros, Syros, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea>
<wicri:noRegion>59045, Lille</wicri:noRegion>
<wicri:noRegion>59045, Lille</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea>
<wicri:noRegion>59000, Lille</wicri:noRegion>
<wicri:noRegion>59000, Lille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea>
<wicri:noRegion>59045, Lille</wicri:noRegion>
<wicri:noRegion>59045, Lille</wicri:noRegion>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea>
<wicri:noRegion>59000, Lille</wicri:noRegion>
<wicri:noRegion>59000, Lille</wicri:noRegion>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea>
<wicri:noRegion>59037, Lille</wicri:noRegion>
<wicri:noRegion>59037, Lille</wicri:noRegion>
<placeName><settlement type="city">Lille</settlement>
<region type="region" nuts="2">Hauts-de-France</region>
<region type="old region" nuts="2">Nord-Pas-de-Calais</region>
</placeName>
<orgName type="university" n="3">Université Lille 2</orgName>
<orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName>
</affiliation>
</author>
<author><name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
<affiliation wicri:level="1"><nlm:aff id="A9"> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Dept of Neurology and Neuroscience, Univ of Milano-Bicocca, Ospedale San Gerardo, Monza</wicri:regionArea>
<wicri:noRegion>Monza</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
<affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
<affiliation wicri:level="1"><nlm:aff id="A14"> Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Department of Neurology, Royal Victoria Hospital, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
<affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
<affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="3"><nlm:aff id="A21"> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM U744, Institut Pasteur de Lille, Université Lille Nord de France, UDSL, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<affiliation wicri:level="1"><nlm:aff id="A19"> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:regionArea>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
<wicri:noRegion>University of Luebeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name>
<affiliation wicri:level="1"><nlm:aff id="A15"> Dept. Neurology, Goethe University Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Dept. Neurology, Goethe University Frankfurt am Main</wicri:regionArea>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
<wicri:noRegion>Goethe University Frankfurt am Main</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name>
<affiliation wicri:level="1"><nlm:aff id="A22"> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> INSERM, UMR-S 775, Bases moléculaires de la réponse aux xénobiotiques, 45 rue des Saints-Pères, 75270 Paris Cedex 06</wicri:regionArea>
<wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion>
<wicri:noRegion>75270 Paris Cedex 06</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A23"> Université Paris Descartes, F-75005, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Université Paris Descartes, F-75005, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
<region type="région" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Paris-Descartes</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A24"> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Assistance-Publique Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Biochimie, Pharmacogénétique et Oncologie Moléculaire, 20 rue Leblanc, 75908 Paris Cedex 15</wicri:regionArea>
<wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion>
<wicri:noRegion>75908 Paris Cedex 15</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><nlm:aff id="A25"> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea> Dublin Neurological Institute at the Mater Misericordiae University Hospital, and Conway Institute of Biomolecular & Biomedical Research, University College Dublin</wicri:regionArea>
<wicri:noRegion>University College Dublin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<affiliation wicri:level="1"><nlm:aff id="A10"> Inserm, U837, F-59045, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Inserm, U837, F-59045, Lille</wicri:regionArea>
<wicri:noRegion>59045, Lille</wicri:noRegion>
<wicri:noRegion>59045, Lille</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11"> Univ Lille Nord de France, F-59000, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> Univ Lille Nord de France, F-59000, Lille</wicri:regionArea>
<wicri:noRegion>59000, Lille</wicri:noRegion>
<wicri:noRegion>59000, Lille</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A12"> CHRU, F-59037, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea> CHRU, F-59037, Lille</wicri:regionArea>
<wicri:noRegion>59037, Lille</wicri:noRegion>
<wicri:noRegion>59037, Lille</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
<affiliation wicri:level="1"><nlm:aff id="A18"> Department of Neurology, Medical University of Silesia, Katowice, Poland</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea> Department of Neurology, Medical University of Silesia, Katowice</wicri:regionArea>
<wicri:noRegion>Katowice</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<affiliation wicri:level="1"><nlm:aff id="A29"> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Science, Section of Geriatric Psychiatry, Lund University</wicri:regionArea>
<wicri:noRegion>Lund University</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30"> Department of Neurology, Skåne University Hospital, Lund, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Neurology, Skåne University Hospital, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<affiliation wicri:level="1"><nlm:aff id="A31"> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Institute of Neurology, University Magna Graecia, Catanzaro, and Neuroimaging Research Unit, National Research Council, Germaneto</wicri:regionArea>
<wicri:noRegion>Germaneto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name>
<affiliation wicri:level="3"><nlm:aff id="A20"> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea> Center of Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, and German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<affiliation wicri:level="1"><nlm:aff id="A26"> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A27"> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Department of Neurology, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A28"> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> Neurology Research Centre, Royal Brisbane and Women's Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A32"> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea> School of Medicine and Centre for Clinical Research, University of Queensland, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name>
<affiliation wicri:level="1"><nlm:aff id="A33"> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, and Second Department of Neurology, University of Athens Medical School</wicri:regionArea>
<wicri:noRegion>University of Athens Medical School</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
<affiliation wicri:level="1"><nlm:aff id="A13"> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea> Mendel Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo</wicri:regionArea>
<wicri:noRegion>San Giovanni Rotondo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z4H4 BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
<affiliation wicri:level="3"><nlm:aff id="A35"> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea> Department of Clinical Neuroscience and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
<affiliation wicri:level="1"><nlm:aff id="A34"> Department of Neurology, Mayo Clinic, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea>
<wicri:noRegion>FL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
<affiliation wicri:level="1"><nlm:aff id="A16"> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Department of Neurology, Laboratory of Neurogenetics, Faculty of Medicine, University of Thessaly, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17"> Institute of Biomedical Research & Technology, CERETETH, Larissa, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea> Institute of Biomedical Research & Technology, CERETETH, Larissa</wicri:regionArea>
<wicri:noRegion>Larissa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<affiliation wicri:level="1"><nlm:aff id="A36"> Department of Neurology, NorthShore University HealthSystem, Evanston, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Department of Neurology, NorthShore University HealthSystem, Evanston, IL</wicri:regionArea>
<wicri:noRegion>IL</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<affiliation wicri:level="2"><nlm:aff id="A3"> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea> Division of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A37"> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea> Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, V5Z4H4 BC</wicri:regionArea>
<wicri:noRegion>V5Z4H4 BC</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Annals of neurology</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">We studied the independent and joint effects of the genes encoding alpha-synuclein (<italic>SNCA</italic>
) and microtubule associated protein tau (<italic>MAPT</italic>
) in Parkinson's disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P2">Participants of Caucasian ancestry were genotyped for a total of four <italic>SNCA</italic>
(rs2583988, rs181489, rs356219, rs11931074) and two <italic>MAPT</italic>
(rs1052553, rs242557) SNPs. Individual and joint effects of <italic>SNCA</italic>
and <italic>MAPT</italic>
SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied both on a multiplicative and an additive scale, and using a case-control and case-only approach.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Fifteen GEO-PD sites contributed a total of 5302 cases and 4161 controls. All four <italic>SNCA</italic>
SNPs and the <italic>MAPT</italic>
H1-haplotype defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For <italic>SNCA</italic>
, the strongest associations were observed for SNPs located at the 3′ end of the gene. There was no evidence of statistical interaction between any of the four <italic>SNCA</italic>
SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale.</p>
</sec>
<sec id="S4"><title>Interpretation</title>
<p id="P4">This study confirms the association between PD and both <italic>SNCA</italic>
SNPs and the H1 <italic>MAPT</italic>
haplotype. It shows, based on a variety of approaches, that the joint action of variants in these two loci is consistent with independent effects of the genes without additional interacting effects.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pologne</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Floride</li>
<li>Hauts-de-France</li>
<li>Massachusetts</li>
<li>Nord-Pas-de-Calais</li>
<li>Svealand</li>
<li>Trøndelag</li>
<li>Île-de-France</li>
</region>
<settlement><li>Lille</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Trondheim</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université Lille 2</li>
<li>Université Lille Nord de France</li>
<li>Université Paris-Descartes</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
</region>
<name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<name sortKey="Chartier Harlin, Marie Christine" sort="Chartier Harlin, Marie Christine" uniqKey="Chartier Harlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name>
<name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name>
<name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name>
<name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name>
<name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name>
<name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name>
<name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name>
<name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
<name sortKey="Mutez, Eugenie" sort="Mutez, Eugenie" uniqKey="Mutez E" first="Eugénie" last="Mutez">Eugénie Mutez</name>
</country>
<country name="États-Unis"><region name="Floride"><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
</region>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name>
<name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name>
<name sortKey="Soto Ortolaza, Alexandra I" sort="Soto Ortolaza, Alexandra I" uniqKey="Soto Ortolaza A" first="Alexandra I" last="Soto-Ortolaza">Alexandra I. Soto-Ortolaza</name>
<name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name>
</noRegion>
<name sortKey="Bozi, Maria" sort="Bozi, Maria" uniqKey="Bozi M" first="Maria" last="Bozi">Maria Bozi</name>
<name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name>
<name sortKey="Stefanis, Leonidas" sort="Stefanis, Leonidas" uniqKey="Stefanis L" first="Leonidas" last="Stefanis">Leonidas Stefanis</name>
<name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
<name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name>
</country>
<country name="Norvège"><region name="Trøndelag"><name sortKey="Aasly, Jan" sort="Aasly, Jan" uniqKey="Aasly J" first="Jan" last="Aasly">Jan Aasly</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name>
</noRegion>
<name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name>
<name sortKey="Ferrarese, Carlo" sort="Ferrarese, Carlo" uniqKey="Ferrarese C" first="Carlo" last="Ferrarese">Carlo Ferrarese</name>
<name sortKey="Ferraris, Alessandro" sort="Ferraris, Alessandro" uniqKey="Ferraris A" first="Alessandro" last="Ferraris">Alessandro Ferraris</name>
<name sortKey="Quattrone, Aldo" sort="Quattrone, Aldo" uniqKey="Quattrone A" first="Aldo" last="Quattrone">Aldo Quattrone</name>
<name sortKey="Valente, Enza Maria" sort="Valente, Enza Maria" uniqKey="Valente E" first="Enza Maria" last="Valente">Enza Maria Valente</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name>
</noRegion>
<name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Gispert, Suzana" sort="Gispert, Suzana" uniqKey="Gispert S" first="Suzana" last="Gispert">Suzana Gispert</name>
</noRegion>
<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name>
<name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name>
<name sortKey="Van De Loo, Simone" sort="Van De Loo, Simone" uniqKey="Van De Loo S" first="Simone" last="Van De Loo">Simone Van De Loo</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Jasinska Myga, Barbara" sort="Jasinska Myga, Barbara" uniqKey="Jasinska Myga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name>
</noRegion>
<name sortKey="Opala, Grzegorz" sort="Opala, Grzegorz" uniqKey="Opala G" first="Grzegorz" last="Opala">Grzegorz Opala</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
</noRegion>
<name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<name sortKey="Mellick, George D" sort="Mellick, George D" uniqKey="Mellick G" first="George D." last="Mellick">George D. Mellick</name>
<name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
<name sortKey="Silburn, Peter A" sort="Silburn, Peter A" uniqKey="Silburn P" first="Peter A." last="Silburn">Peter A. Silburn</name>
</country>
<country name="Suède"><noRegion><name sortKey="Nilsson, Christer" sort="Nilsson, Christer" uniqKey="Nilsson C" first="Christer" last="Nilsson">Christer Nilsson</name>
</noRegion>
<name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name>
<name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name>
</country>
<country name="Canada"><noRegion><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
</noRegion>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
</country>
</tree>
</affiliations>
</record>
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