Striatal blood–brain barrier permeability in Parkinson's disease
Identifieur interne : 000530 ( Main/Merge ); précédent : 000529; suivant : 000531Striatal blood–brain barrier permeability in Parkinson's disease
Auteurs : Madison T. Gray [Canada] ; John M. Woulfe [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Biomarkers (metabolism), Blood Proteins (metabolism), Blood-Brain Barrier (metabolism), Blood-Brain Barrier (pathology), Capillary Permeability, Erythrocytes (metabolism), Erythrocytes (pathology), Female, Humans, Iron (metabolism), Male, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- chemical , metabolism : Biomarkers, Blood Proteins, Iron.
- metabolism : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- pathology : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- Aged, Aged, 80 and over, Capillary Permeability, Female, Humans, Male, Middle Aged.
Abstract
Url:
DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
PubMed Central: 4420870
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PMC:4420870Le document en format XML
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
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