Striatal blood-brain barrier permeability in Parkinson's disease.
Identifieur interne : 000511 ( PubMed/Corpus ); précédent : 000510; suivant : 000512Striatal blood-brain barrier permeability in Parkinson's disease.
Auteurs : Madison T. Gray ; John M. WoulfeSource :
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [ 1559-7016 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Biomarkers (metabolism), Blood Proteins (metabolism), Blood-Brain Barrier (metabolism), Blood-Brain Barrier (pathology), Capillary Permeability, Erythrocytes (metabolism), Erythrocytes (pathology), Female, Humans, Iron (metabolism), Male, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (pathology).
- MESH :
- chemical , metabolism : Biomarkers, Blood Proteins, Iron.
- metabolism : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- pathology : Blood-Brain Barrier, Erythrocytes, Parkinson Disease.
- Aged, Aged, 80 and over, Capillary Permeability, Female, Humans, Male, Middle Aged.
Abstract
In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.
DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
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pubmed:25757748Le document en format XML
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Woulfe</name><affiliation><nlm:affiliation>1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25757748</idno><idno type="pmid">25757748</idno><idno type="doi">10.1038/jcbfm.2015.32</idno><idno type="wicri:Area/PubMed/Corpus">000511</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000511</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Striatal blood-brain barrier permeability in Parkinson's disease.</title><author><name sortKey="Gray, Madison T" sort="Gray, Madison T" uniqKey="Gray M" first="Madison T" last="Gray">Madison T. Gray</name><affiliation><nlm:affiliation>1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Woulfe, John M" sort="Woulfe, John M" uniqKey="Woulfe J" first="John M" last="Woulfe">John M. Woulfe</name><affiliation><nlm:affiliation>1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</title><idno type="eISSN">1559-7016</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Biomarkers (metabolism)</term><term>Blood Proteins (metabolism)</term><term>Blood-Brain Barrier (metabolism)</term><term>Blood-Brain Barrier (pathology)</term><term>Capillary Permeability</term><term>Erythrocytes (metabolism)</term><term>Erythrocytes (pathology)</term><term>Female</term><term>Humans</term><term>Iron (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biomarkers</term><term>Blood Proteins</term><term>Iron</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Blood-Brain Barrier</term><term>Erythrocytes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Blood-Brain Barrier</term><term>Erythrocytes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Capillary Permeability</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25757748</PMID><DateCreated><Year>2015</Year><Month>04</Month><Day>30</Day></DateCreated><DateCompleted><Year>2015</Year><Month>06</Month><Day>11</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1559-7016</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism</Title><ISOAbbreviation>J. Cereb. Blood Flow Metab.</ISOAbbreviation></Journal><ArticleTitle>Striatal blood-brain barrier permeability in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>747-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/jcbfm.2015.32</ELocationID><Abstract><AbstractText>In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gray</LastName><ForeName>Madison T</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woulfe</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList 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