Striatal blood–brain barrier permeability in Parkinson's disease
Identifieur interne : 000204 ( Pmc/Checkpoint ); précédent : 000203; suivant : 000205Striatal blood–brain barrier permeability in Parkinson's disease
Auteurs : Madison T. Gray [Canada] ; John M. Woulfe [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2015.
Abstract
Url:
DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
PubMed Central: 4420870
Affiliations:
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PMC:4420870Le document en format XML
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<series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title>
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
</div>
</front>
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<pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cereb Blood Flow Metab</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Cereb. Blood Flow Metab</journal-id>
<journal-title-group><journal-title>Journal of Cerebral Blood Flow & Metabolism</journal-title>
</journal-title-group>
<issn pub-type="ppub">0271-678X</issn>
<issn pub-type="epub">1559-7016</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
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<article-meta><article-id pub-id-type="pmid">25757748</article-id>
<article-id pub-id-type="pmc">4420870</article-id>
<article-id pub-id-type="pii">jcbfm201532</article-id>
<article-id pub-id-type="doi">10.1038/jcbfm.2015.32</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>Striatal blood–brain barrier permeability in Parkinson's disease</article-title>
<alt-title alt-title-type="running">Striatal BBB in Parkinson's</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gray</surname>
<given-names>Madison T</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woulfe</surname>
<given-names>John M</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
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<aff id="aff1"><label>1</label>
<institution>Faculty of Medicine, University of Ottawa</institution>
, Ottawa, Ontario,<country>Canada</country>
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<aff id="aff2"><label>2</label>
<institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
, Ottawa, Ontario,<country>Canada</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Department of Pathology and Laboratory Medicine, The Ottawa Hospital</institution>
, Ottawa, Ontario,<country>Canada</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
<institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
, Box 926, 501 Smyth Road, Ottawa, Ontario, <country>Canada</country>
. E-mail: <email>jwoulfe@ottawahospital.on.ca</email>
</corresp>
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<pub-date pub-type="ppub"><month>05</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>03</month>
<year>2015</year>
</pub-date>
<volume>35</volume>
<issue>5</issue>
<fpage>747</fpage>
<lpage>750</lpage>
<history><date date-type="received"><day>23</day>
<month>10</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>09</day>
<month>01</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>03</day>
<month>02</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-holder>
</permissions>
<abstract><p><italic>In vivo</italic>
studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
</abstract>
<kwd-group><kwd><italic>α</italic>
-synuclein</kwd>
<kwd>blood–brain barrier</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>striatum</kwd>
</kwd-group>
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