ParkinsonCanadaV1, Pmc, Checkpoint, bibRecord, 000204

Striatal blood–brain barrier permeability in Parkinson's disease

Identifieur interne : 000204 ( Pmc/Checkpoint ); précédent : 000203; suivant : 000205

Striatal blood–brain barrier permeability in Parkinson's disease

Auteurs : Madison T. Gray [Canada] ; John M. Woulfe [Canada]

Source :

Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2015.

RBID : PMC:4420870

Abstract

In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420870

DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
PubMed Central: 4420870

Affiliations:

Canada

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PMC:4420870

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
 studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
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  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Cereb Blood Flow Metab</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject>
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<title-group><article-title>Striatal blood–brain barrier permeability in Parkinson's disease</article-title>
<alt-title alt-title-type="running">Striatal BBB in Parkinson's</alt-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Gray</surname>
<given-names>Madison T</given-names>
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<author-notes><corresp id="caf1"><label>*</label>
<institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
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. E-mail: <email>jwoulfe@ottawahospital.on.ca</email>
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<pub-date pub-type="ppub"><month>05</month>
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<permissions><copyright-statement>Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-statement>
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<copyright-holder>International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-holder>
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<abstract><p><italic>In vivo</italic>
 studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
</abstract>
<kwd-group><kwd><italic>α</italic>
-synuclein</kwd>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Striatal blood–brain barrier permeability in Parkinson's disease

Striatal blood–brain barrier permeability in Parkinson's disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki