ParkinsonCanadaV1, Pmc, Corpus, bibRecord, 000002

Striatal blood–brain barrier permeability in Parkinson's disease

Identifieur interne : 000002 ( Pmc/Corpus ); précédent : 000001; suivant : 000003

Striatal blood–brain barrier permeability in Parkinson's disease

Auteurs : Madison T. Gray ; John M. Woulfe

Source :

Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2015.

RBID : PMC:4420870

Abstract

In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420870

DOI: 10.1038/jcbfm.2015.32
PubMed: 25757748
PubMed Central: 4420870

Links to Exploration step

PMC:4420870

Le document en format XML

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<author><name sortKey="Gray, Madison T" sort="Gray, Madison T" uniqKey="Gray M" first="Madison T" last="Gray">Madison T. Gray</name>
<affiliation><nlm:aff id="aff1"><institution>Faculty of Medicine, University of Ottawa</institution>
, Ottawa, Ontario,<country>Canada</country>
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<affiliation><nlm:aff id="aff2"><institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
, Ottawa, Ontario,<country>Canada</country>
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<author><name sortKey="Woulfe, John M" sort="Woulfe, John M" uniqKey="Woulfe J" first="John M" last="Woulfe">John M. Woulfe</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Striatal blood–brain barrier permeability in Parkinson's disease</title>
<author><name sortKey="Gray, Madison T" sort="Gray, Madison T" uniqKey="Gray M" first="Madison T" last="Gray">Madison T. Gray</name>
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<author><name sortKey="Woulfe, John M" sort="Woulfe, John M" uniqKey="Woulfe J" first="John M" last="Woulfe">John M. Woulfe</name>
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, Ottawa, Ontario,<country>Canada</country>
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<series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title>
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
 studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
</div>
</front>
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<pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Cereb Blood Flow Metab</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Cereb. Blood Flow Metab</journal-id>
<journal-title-group><journal-title>Journal of Cerebral Blood Flow & Metabolism</journal-title>
</journal-title-group>
<issn pub-type="ppub">0271-678X</issn>
<issn pub-type="epub">1559-7016</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
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<article-meta><article-id pub-id-type="pmid">25757748</article-id>
<article-id pub-id-type="pmc">4420870</article-id>
<article-id pub-id-type="pii">jcbfm201532</article-id>
<article-id pub-id-type="doi">10.1038/jcbfm.2015.32</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>Striatal blood–brain barrier permeability in Parkinson's disease</article-title>
<alt-title alt-title-type="running">Striatal BBB in Parkinson's</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Gray</surname>
<given-names>Madison T</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Woulfe</surname>
<given-names>John M</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
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<aff id="aff1"><label>1</label>
<institution>Faculty of Medicine, University of Ottawa</institution>
, Ottawa, Ontario,<country>Canada</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
, Ottawa, Ontario,<country>Canada</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>Department of Pathology and Laboratory Medicine, The Ottawa Hospital</institution>
, Ottawa, Ontario,<country>Canada</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
<institution>Centre for Cancer Therapeutics, Ottawa Hospital Research Institute</institution>
, Box 926, 501 Smyth Road, Ottawa, Ontario, <country>Canada</country>
. E-mail: <email>jwoulfe@ottawahospital.on.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>05</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>03</month>
<year>2015</year>
</pub-date>
<volume>35</volume>
<issue>5</issue>
<fpage>747</fpage>
<lpage>750</lpage>
<history><date date-type="received"><day>23</day>
<month>10</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>09</day>
<month>01</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>03</day>
<month>02</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>International Society for Cerebral Blood Flow & Metabolism, Inc.</copyright-holder>
</permissions>
<abstract><p><italic>In vivo</italic>
 studies have shown that blood–brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.</p>
</abstract>
<kwd-group><kwd><italic>α</italic>
-synuclein</kwd>
<kwd>blood–brain barrier</kwd>
<kwd>Parkinson's disease</kwd>
<kwd>striatum</kwd>
</kwd-group>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Striatal blood–brain barrier permeability in Parkinson's disease

Striatal blood–brain barrier permeability in Parkinson's disease

Source :

Abstract

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