Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Identifieur interne : 004476 ( Main/Exploration ); précédent : 004475; suivant : 004477Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Auteurs : B. Gomez-Mancilla [Canada] ; P J BédardSource :
- Neuroscience letters [ 0304-3940 ] ; 1992.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Drug Therapy, Combination, Dyskinesia, Drug-Induced (physiopathology), Dyskinesia, Drug-Induced (prevention & control), Estradiol (therapeutic use), Female, Levodopa (therapeutic use), Levodopa (toxicity), Macaca fascicularis, Parkinson Disease, Secondary (drug therapy), Progesterone (therapeutic use).
- MESH :
- chemical , therapeutic use : Estradiol, Levodopa, Progesterone.
- chemical , toxicity : Levodopa.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug therapy : Parkinson Disease, Secondary.
- physiopathology : Dyskinesia, Drug-Induced.
- prevention & control : Dyskinesia, Drug-Induced.
- Animals, Drug Therapy, Combination, Female, Macaca fascicularis.
Abstract
A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.
PubMed: 1542429
Affiliations:
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Le document en format XML
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Gomez-Mancilla</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1542429</idno><idno type="pmid">1542429</idno><idno type="wicri:Area/PubMed/Corpus">001A84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A84</idno><idno type="wicri:Area/PubMed/Curation">001A84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A84</idno><idno type="wicri:Area/PubMed/Checkpoint">001A84</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001A84</idno><idno type="wicri:Area/Ncbi/Merge">000463</idno><idno type="wicri:Area/Ncbi/Curation">000463</idno><idno type="wicri:Area/Ncbi/Checkpoint">000463</idno><idno type="wicri:doubleKey">0304-3940:1992:Gomez Mancilla B:effect:of:estrogen</idno><idno type="wicri:Area/Main/Merge">004D08</idno><idno type="wicri:Area/Main/Curation">004476</idno><idno type="wicri:Area/Main/Exploration">004476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.</title><author><name sortKey="Gomez Mancilla, B" sort="Gomez Mancilla, B" uniqKey="Gomez Mancilla B" first="B" last="Gomez-Mancilla">B. Gomez-Mancilla</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="ISSN">0304-3940</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Drug Therapy, Combination</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Dyskinesia, Drug-Induced (prevention & control)</term><term>Estradiol (therapeutic use)</term><term>Female</term><term>Levodopa (therapeutic use)</term><term>Levodopa (toxicity)</term><term>Macaca fascicularis</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Progesterone (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Estradiol</term><term>Levodopa</term><term>Progesterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Female</term><term>Macaca fascicularis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></noCountry><country name="Canada"><noRegion><name sortKey="Gomez Mancilla, B" sort="Gomez Mancilla, B" uniqKey="Gomez Mancilla B" first="B" last="Gomez-Mancilla">B. Gomez-Mancilla</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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