Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Identifieur interne : 000463 ( Ncbi/Checkpoint ); précédent : 000462; suivant : 000464Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Auteurs : B. Gomez-Mancilla [Canada] ; P J BédardSource :
- Neuroscience letters [ 0304-3940 ] ; 1992.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Drug Therapy, Combination, Dyskinesia, Drug-Induced (physiopathology), Dyskinesia, Drug-Induced (prevention & control), Estradiol (therapeutic use), Female, Levodopa (therapeutic use), Levodopa (toxicity), Macaca fascicularis, Parkinson Disease, Secondary (drug therapy), Progesterone (therapeutic use).
- MESH :
- chemical , therapeutic use : Estradiol, Levodopa, Progesterone.
- chemical , toxicity : Levodopa.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug therapy : Parkinson Disease, Secondary.
- physiopathology : Dyskinesia, Drug-Induced.
- prevention & control : Dyskinesia, Drug-Induced.
- Animals, Drug Therapy, Combination, Female, Macaca fascicularis.
Abstract
A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.
PubMed: 1542429
Affiliations:
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pubmed:1542429Le document en format XML
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<author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name>
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<front><div type="abstract" xml:lang="en">A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.</div>
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