Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Identifieur interne : 001A84 ( PubMed/Curation ); précédent : 001A83; suivant : 001A85Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
Auteurs : B. Gomez-Mancilla [Canada] ; P J BédardSource :
- Neuroscience letters [ 0304-3940 ] ; 1992.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Drug Therapy, Combination, Dyskinesia, Drug-Induced (physiopathology), Dyskinesia, Drug-Induced (prevention & control), Estradiol (therapeutic use), Female, Levodopa (therapeutic use), Levodopa (toxicity), Macaca fascicularis, Parkinson Disease, Secondary (drug therapy), Progesterone (therapeutic use).
- MESH :
- chemical , therapeutic use : Estradiol, Levodopa, Progesterone.
- chemical , toxicity : Levodopa.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug therapy : Parkinson Disease, Secondary.
- physiopathology : Dyskinesia, Drug-Induced.
- prevention & control : Dyskinesia, Drug-Induced.
- Animals, Drug Therapy, Combination, Female, Macaca fascicularis.
Abstract
A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.
PubMed: 1542429
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Gomez-Mancilla</name><affiliation wicri:level="1"><nlm:affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec</wicri:regionArea></affiliation></author><author><name sortKey="Bedard, P J" sort="Bedard, P J" uniqKey="Bedard P" first="P J" last="Bédard">P J Bédard</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="ISSN">0304-3940</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Animals</term><term>Drug Therapy, Combination</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Dyskinesia, Drug-Induced (prevention & control)</term><term>Estradiol (therapeutic use)</term><term>Female</term><term>Levodopa (therapeutic use)</term><term>Levodopa (toxicity)</term><term>Macaca fascicularis</term><term>Parkinson Disease, Secondary (drug therapy)</term><term>Progesterone (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Estradiol</term><term>Levodopa</term><term>Progesterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Therapy, Combination</term><term>Female</term><term>Macaca fascicularis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1542429</PMID><DateCreated><Year>1992</Year><Month>04</Month><Day>03</Day></DateCreated><DateCompleted><Year>1992</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3940</ISSN><JournalIssue CitedMedium="Print"><Volume>135</Volume><Issue>1</Issue><PubDate><Year>1992</Year><Month>Jan</Month><Day>20</Day></PubDate></JournalIssue><Title>Neuroscience letters</Title><ISOAbbreviation>Neurosci. Lett.</ISOAbbreviation></Journal><ArticleTitle>Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.</ArticleTitle><Pagination><MedlinePgn>129-32</MedlinePgn></Pagination><Abstract><AbstractText>A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gomez-Mancilla</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bédard</LastName><ForeName>P J</ForeName><Initials>PJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Neurosci Lett</MedlineTA><NlmUniqueID>7600130</NlmUniqueID><ISSNLinking>0304-3940</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>4G7DS2Q64Y</RegistryNumber><NameOfSubstance UI="D011374">Progesterone</NameOfSubstance></Chemical><Chemical><RegistryNumber>4TI98Z838E</RegistryNumber><NameOfSubstance UI="D004958">Estradiol</NameOfSubstance></Chemical><Chemical><RegistryNumber>9P21XSP91P</RegistryNumber><NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="Y">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004958" MajorTopicYN="N">Estradiol</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008252" MajorTopicYN="N">Macaca fascicularis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010302" MajorTopicYN="N">Parkinson Disease, Secondary</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011374" MajorTopicYN="N">Progesterone</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>1</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>1</Month><Day>20</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>1</Month><Day>20</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1542429</ArticleId><ArticleId IdType="pii">0304-3940(92)90152-W</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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