Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins
Identifieur interne : 002B35 ( Main/Exploration ); précédent : 002B34; suivant : 002B36Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins
Auteurs : Thomas E. Marler [États-Unis] ; Vivian Lee [Canada] ; Christopher A. Shaw [Canada]Source :
- HortScience [ 0018-5345 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Norme, Santé publique, Homme, Horticulture.
English descriptors
- KwdEn :
Abstract
Consumption of Cycas micronesica seed tissue has been associated with the amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of the Western Pacific. However, failures to document vital plant and neighborhood descriptors and pronounced variability in toxin concentrations noted within and among studies obfuscate decades of research on this subject. We discuss the theoretical and experimental constraints of plant tissue sampling in relation to human disease research. Comparisons are made between this approach and methods used throughout the history of ALS-PDC research, most notably very recent reports concerning β-methyl-amino-alanine. Methods for studying possible plant neurotoxins need to be standardized and must follow rigorous criteria to be valid in principle. Our discussions reveal why these criteria are essential and highlight the impact that natural variations have on environmental toxin quantification and interpretation. Past research on cycad toxins is deficient on experimental and theoretical grounds, and interpretation of published data is dominated by ambiguities. This area of study as conventionally conceived and carried out needs transforming. We argue that future empirical studies should honor appropriate plant science standards concomitantly with medical science standards. This dual focus will ensure appropriate sampling scheme, sample size, and reporting of background plant and community factors known to influence phenotypic plasticity.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000889
- to stream PascalFrancis, to step Curation: 000434
- to stream PascalFrancis, to step Checkpoint: 000806
- to stream Main, to step Merge: 002E74
- to stream Main, to step Curation: 002B35
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins</title><author><name sortKey="Marler, Thomas E" sort="Marler, Thomas E" uniqKey="Marler T" first="Thomas E." last="Marler">Thomas E. Marler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>College of Natural and Applied Sciences, University of Guam, UOG Station</s1><s2>Mangilao, Guam 96923</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mangilao, Guam 96923</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Vivian" sort="Lee, Vivian" uniqKey="Lee V" first="Vivian" last="Lee">Vivian Lee</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology, University of British Columbia</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology, University of British Columbia</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0424320</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0424320 INIST</idno><idno type="RBID">Pascal:05-0424320</idno><idno type="wicri:Area/PascalFrancis/Corpus">000889</idno><idno type="wicri:Area/PascalFrancis/Curation">000434</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000806</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000806</idno><idno type="wicri:doubleKey">0018-5345:2005:Marler T:cycad:toxins:and</idno><idno type="wicri:Area/Main/Merge">002E74</idno><idno type="wicri:Area/Main/Curation">002B35</idno><idno type="wicri:Area/Main/Exploration">002B35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins</title><author><name sortKey="Marler, Thomas E" sort="Marler, Thomas E" uniqKey="Marler T" first="Thomas E." last="Marler">Thomas E. Marler</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>College of Natural and Applied Sciences, University of Guam, UOG Station</s1><s2>Mangilao, Guam 96923</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mangilao, Guam 96923</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Vivian" sort="Lee, Vivian" uniqKey="Lee V" first="Vivian" last="Lee">Vivian Lee</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology, University of British Columbia</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. Shaw</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Ophthalmology, University of British Columbia</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">HortScience</title><title level="j" type="abbreviated">HortScience</title><idno type="ISSN">0018-5345</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">HortScience</title><title level="j" type="abbreviated">HortScience</title><idno type="ISSN">0018-5345</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amyotrophic lateral sclerosis</term><term>Cycadales</term><term>Endemic species</term><term>Glucoside</term><term>Guam</term><term>Guam Parkinson dementia</term><term>Horticulture</term><term>Human</term><term>Neurological disorder</term><term>Neurotoxin</term><term>Parkinsonism</term><term>Public health</term><term>Secondary constituent</term><term>Standard</term><term>Standards</term><term>Steroid</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble neurologique</term><term>Etalon</term><term>Norme</term><term>Santé publique</term><term>Homme</term><term>Sclérose latérale amyotrophique</term><term>Parkinsonisme</term><term>Parkinson démence ile de Guam</term><term>Neurotoxine</term><term>Cycadales</term><term>Espèce endémique</term><term>Glucoside</term><term>Guam</term><term>Constituant secondaire</term><term>Stéroïde</term><term>Horticulture</term><term>Cycas micronesica</term><term>Alanine(3-méthylamino)</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Norme</term><term>Santé publique</term><term>Homme</term><term>Horticulture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Consumption of Cycas micronesica seed tissue has been associated with the amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of the Western Pacific. However, failures to document vital plant and neighborhood descriptors and pronounced variability in toxin concentrations noted within and among studies obfuscate decades of research on this subject. We discuss the theoretical and experimental constraints of plant tissue sampling in relation to human disease research. Comparisons are made between this approach and methods used throughout the history of ALS-PDC research, most notably very recent reports concerning β-methyl-amino-alanine. Methods for studying possible plant neurotoxins need to be standardized and must follow rigorous criteria to be valid in principle. Our discussions reveal why these criteria are essential and highlight the impact that natural variations have on environmental toxin quantification and interpretation. Past research on cycad toxins is deficient on experimental and theoretical grounds, and interpretation of published data is dominated by ambiguities. This area of study as conventionally conceived and carried out needs transforming. We argue that future empirical studies should honor appropriate plant science standards concomitantly with medical science standards. This dual focus will ensure appropriate sampling scheme, sample size, and reporting of background plant and community factors known to influence phenotypic plasticity.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Marler, Thomas E" sort="Marler, Thomas E" uniqKey="Marler T" first="Thomas E." last="Marler">Thomas E. Marler</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Lee, Vivian" sort="Lee, Vivian" uniqKey="Lee V" first="Vivian" last="Lee">Vivian Lee</name></noRegion><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. Shaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002B35 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002B35 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:05-0424320
|texte= Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins
}}
| This area was generated with Dilib version V0.6.29. |  |