ParkinsonCanadaV1, Main, Exploration, bibRecord, 002B34

Deficits in saccadic eye-movement control in Parkinson's disease

Identifieur interne : 002B34 ( Main/Exploration ); précédent : 002B33; suivant : 002B35

Deficits in saccadic eye-movement control in Parkinson's disease

Auteurs : Florence Chan [Canada] ; Irene T. Armstrong [Canada] ; Giovanna Pari [Canada] ; Richard J. Riopelle [Canada] ; Douglas P. Munoz [Canada]

Source :

Neuropsychologia [ 0028-3932 ] ; 2005.

RBID : Pascal:05-0165101

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Mouvement oculaire saccadé, Cortex frontal, Contrôle volontaire, Inhibition, Mémoire, Noyau gris central, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Attention (physiology), Basal ganglion, Case-Control Studies, Female, Frontal cortex, Human, Humans, Inhibition, Male, Memory, Middle Aged, Ocular Motility Disorders (etiology), Parkinson Disease (physiopathology), Parkinson disease, Photic Stimulation (methods), Psychomotor Performance (physiology), Reaction Time (physiology), Saccades (physiology), Saccadic eye movement, Task Performance and Analysis, Time Factors, Voluntary control.
MESH :
- etiology : Ocular Motility Disorders.
- methods : Photic Stimulation.
- physiology : Attention, Psychomotor Performance, Reaction Time, Saccades.
- physiopathology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Male, Middle Aged, Task Performance and Analysis, Time Factors.

Abstract

In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.

Affiliations:

Canada

Le document en format XML

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<term>Psychomotor Performance (physiology)</term>
<term>Reaction Time (physiology)</term>
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<front><div type="abstract" xml:lang="en">In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Deficits in saccadic eye-movement control in Parkinson's disease

Deficits in saccadic eye-movement control in Parkinson's disease

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	La maladie de Parkinson au Canada (serveur d'exploration)
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