ParkinsonCanadaV1, PascalFrancis, Curation, bibRecord, 000434

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Identifieur interne : 000434 ( PascalFrancis/Curation ); précédent : 000433; suivant : 000435

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Auteurs : Thomas E. Marler [États-Unis] ; Vivian Lee [Canada] ; Christopher A. Shaw [Canada]

Source :

HortScience [ 0018-5345 ] ; 2005.

RBID : Pascal:05-0424320

Descripteurs français

Pascal (Inist)
- Trouble neurologique, Etalon, Norme, Santé publique, Homme, Sclérose latérale amyotrophique, Parkinsonisme, Parkinson démence ile de Guam, Neurotoxine, Cycadales, Espèce endémique, Glucoside, Guam, Constituant secondaire, Stéroïde, Horticulture, Cycas micronesica, Alanine(3-méthylamino).
Wicri :
- topic : Norme, Santé publique, Homme, Horticulture.

English descriptors

KwdEn :
- Amyotrophic lateral sclerosis, Cycadales, Endemic species, Glucoside, Guam, Guam Parkinson dementia, Horticulture, Human, Neurological disorder, Neurotoxin, Parkinsonism, Public health, Secondary constituent, Standard, Standards, Steroid.

Abstract

Consumption of Cycas micronesica seed tissue has been associated with the amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of the Western Pacific. However, failures to document vital plant and neighborhood descriptors and pronounced variability in toxin concentrations noted within and among studies obfuscate decades of research on this subject. We discuss the theoretical and experimental constraints of plant tissue sampling in relation to human disease research. Comparisons are made between this approach and methods used throughout the history of ALS-PDC research, most notably very recent reports concerning β-methyl-amino-alanine. Methods for studying possible plant neurotoxins need to be standardized and must follow rigorous criteria to be valid in principle. Our discussions reveal why these criteria are essential and highlight the impact that natural variations have on environmental toxin quantification and interpretation. Past research on cycad toxins is deficient on experimental and theoretical grounds, and interpretation of published data is dominated by ambiguities. This area of study as conventionally conceived and carried out needs transforming. We argue that future empirical studies should honor appropriate plant science standards concomitantly with medical science standards. This dual focus will ensure appropriate sampling scheme, sample size, and reporting of background plant and community factors known to influence phenotypic plasticity.

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<fC03 i1="04" i2="X" l="ENG"><s0>Public health</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Human</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Sclérose latérale amyotrophique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Amyotrophic lateral sclerosis</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Esclerosis lateral amiotrófica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Parkinsonisme</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Parkinsonism</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Parkinson síndrome</s0>
<s2>NM</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Parkinson démence ile de Guam</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Guam Parkinson dementia</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Demencia Guam Parkinson</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Neurotoxine</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Neurotoxin</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Neurotoxina</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Cycadales</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Cycadales</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Cycadales</s0>
<s2>NS</s2>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Espèce endémique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Endemic species</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Especie endémica</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Glucoside</s0>
<s5>16</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Glucoside</s0>
<s5>16</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Glucósido</s0>
<s5>16</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Guam</s0>
<s2>NG</s2>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Guam</s0>
<s2>NG</s2>
<s5>20</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Guam</s0>
<s2>NG</s2>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Constituant secondaire</s0>
<s5>28</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Secondary constituent</s0>
<s5>28</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Constituyente secundario</s0>
<s5>28</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Stéroïde</s0>
<s5>29</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Steroid</s0>
<s5>29</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Esteroide</s0>
<s5>29</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Horticulture</s0>
<s5>30</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Horticulture</s0>
<s5>30</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Horticultura</s0>
<s5>30</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Cycas micronesica</s0>
<s4>INC</s4>
<s5>72</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Alanine(3-méthylamino)</s0>
<s4>INC</s4>
<s5>78</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Toxine</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Toxin</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Toxina</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Gymnospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Gymnospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Gymnospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mariannes</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mariana Islands</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Marianas</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Micronésie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Micronesia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Micronesia</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Océanie</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Oceania</s0>
<s2>NG</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>33</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>33</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>33</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>34</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>34</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>34</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Moelle épinière pathologie</s0>
<s5>35</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Spinal cord disease</s0>
<s5>35</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Médula espinal patología</s0>
<s5>35</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Aminoacide</s0>
<s5>50</s5>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Aminoacid</s0>
<s5>50</s5>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Aminoácido</s0>
<s5>50</s5>
</fC07>
<fN21><s1>297</s1>
</fN21>
</pA>
</standard>
</inist>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

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