ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000806

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Identifieur interne : 000806 ( PascalFrancis/Checkpoint ); précédent : 000805; suivant : 000807

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Auteurs : Thomas E. Marler [États-Unis] ; Vivian Lee [Canada] ; Christopher A. Shaw [Canada]

Source :

HortScience [ 0018-5345 ] ; 2005.

RBID : Pascal:05-0424320

Descripteurs français

Pascal (Inist)
- Trouble neurologique, Etalon, Norme, Santé publique, Homme, Sclérose latérale amyotrophique, Parkinsonisme, Parkinson démence ile de Guam, Neurotoxine, Cycadales, Espèce endémique, Glucoside, Guam, Constituant secondaire, Stéroïde, Horticulture, Cycas micronesica, Alanine(3-méthylamino).
Wicri :
- topic : Norme, Santé publique, Homme, Horticulture.

English descriptors

KwdEn :
- Amyotrophic lateral sclerosis, Cycadales, Endemic species, Glucoside, Guam, Guam Parkinson dementia, Horticulture, Human, Neurological disorder, Neurotoxin, Parkinsonism, Public health, Secondary constituent, Standard, Standards, Steroid.

Abstract

Consumption of Cycas micronesica seed tissue has been associated with the amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of the Western Pacific. However, failures to document vital plant and neighborhood descriptors and pronounced variability in toxin concentrations noted within and among studies obfuscate decades of research on this subject. We discuss the theoretical and experimental constraints of plant tissue sampling in relation to human disease research. Comparisons are made between this approach and methods used throughout the history of ALS-PDC research, most notably very recent reports concerning β-methyl-amino-alanine. Methods for studying possible plant neurotoxins need to be standardized and must follow rigorous criteria to be valid in principle. Our discussions reveal why these criteria are essential and highlight the impact that natural variations have on environmental toxin quantification and interpretation. Past research on cycad toxins is deficient on experimental and theoretical grounds, and interpretation of published data is dominated by ambiguities. This area of study as conventionally conceived and carried out needs transforming. We argue that future empirical studies should honor appropriate plant science standards concomitantly with medical science standards. This dual focus will ensure appropriate sampling scheme, sample size, and reporting of background plant and community factors known to influence phenotypic plasticity.

Affiliations:

Canada, États-Unis

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Consumption of Cycas micronesica seed tissue has been associated with the amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC) of the Western Pacific. However, failures to document vital plant and neighborhood descriptors and pronounced variability in toxin concentrations noted within and among studies obfuscate decades of research on this subject. We discuss the theoretical and experimental constraints of plant tissue sampling in relation to human disease research. Comparisons are made between this approach and methods used throughout the history of ALS-PDC research, most notably very recent reports concerning β-methyl-amino-alanine. Methods for studying possible plant neurotoxins need to be standardized and must follow rigorous criteria to be valid in principle. Our discussions reveal why these criteria are essential and highlight the impact that natural variations have on environmental toxin quantification and interpretation. Past research on cycad toxins is deficient on experimental and theoretical grounds, and interpretation of published data is dominated by ambiguities. This area of study as conventionally conceived and carried out needs transforming. We argue that future empirical studies should honor appropriate plant science standards concomitantly with medical science standards. This dual focus will ensure appropriate sampling scheme, sample size, and reporting of background plant and community factors known to influence phenotypic plasticity.</div>
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<s5>33</s5>
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<s5>33</s5>
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<s5>34</s5>
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</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>34</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Moelle épinière pathologie</s0>
<s5>35</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Spinal cord disease</s0>
<s5>35</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Médula espinal patología</s0>
<s5>35</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>36</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Aminoacide</s0>
<s5>50</s5>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Aminoacid</s0>
<s5>50</s5>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Aminoácido</s0>
<s5>50</s5>
</fC07>
<fN21><s1>297</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Marler, Thomas E" sort="Marler, Thomas E" uniqKey="Marler T" first="Thomas E." last="Marler">Thomas E. Marler</name>
</noRegion>
</country>
<country name="Canada"><noRegion><name sortKey="Lee, Vivian" sort="Lee, Vivian" uniqKey="Lee V" first="Vivian" last="Lee">Vivian Lee</name>
</noRegion>
<name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. Shaw</name>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

Cycad toxins and neurological diseases in guam : Defining theoretical and experimental standards for correlating human disease with environmental toxins

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