ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000925

Deficits in saccadic eye-movement control in Parkinson's disease

Identifieur interne : 000925 ( PascalFrancis/Corpus ); précédent : 000924; suivant : 000926

Deficits in saccadic eye-movement control in Parkinson's disease

Auteurs : Florence Chan ; Irene T. Armstrong ; Giovanna Pari ; Richard J. Riopelle ; Douglas P. Munoz

Source :

Neuropsychologia [ 0028-3932 ] ; 2005.

RBID : Pascal:05-0165101

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Mouvement oculaire saccadé, Cortex frontal, Contrôle volontaire, Inhibition, Mémoire, Noyau gris central, Homme.

English descriptors

KwdEn :
- Basal ganglion, Frontal cortex, Human, Inhibition, Memory, Parkinson disease, Saccadic eye movement, Voluntary control.

Abstract

In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0028-3932`
A02	`01`			`@0 NUPSA6`
A03		`1`		`@0 Neuropsychologia`
A05				`@2 43`
A06				`@2 5`
A08	`01`	`1`	`ENG`	`@1 Deficits in saccadic eye-movement control in Parkinson's disease`
A11	`01`	`1`		`@1 CHAN (Florence)`
A11	`02`	`1`		`@1 ARMSTRONG (Irene T.)`
A11	`03`	`1`		`@1 PARI (Giovanna)`
A11	`04`	`1`		`@1 RIOPELLE (Richard J.)`
A11	`05`	`1`		`@1 MUNOZ (Douglas P.)`
A14	`01`			`@1 Centre for Neuroscience Studies, Queen's University @2 Kingston, Ont., K7L 3N6 @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Physiology, Centre for Neuroscience Studies, Queen's University @2 Kingston, Ont., K7L 3N6 @3 CAN @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A14	`03`			`@1 Department of Medicine, Centre for Neuroscience Studies, Queen's University @2 Kingston, Ont., K7L 3N6 @3 CAN @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 Department of Psychology, Centre for Neuroscience Studies, Queen's University @2 Kingston, Ont., K7L 3N6 @3 CAN @Z 5 aut.`
A20				`@1 784-796`
A21				`@1 2005`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 11143 @5 354000125006590130`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 2 p.1/4`
A47	`01`	`1`		`@0 05-0165101`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Neuropsychologia`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.
C02	`01`	`X`		`@0 002B18C13`
C02	`02`	`X`		`@0 002B17G`
C03	`01`	`X`	`FRE`	`@0 Parkinson maladie @5 01`
C03	`01`	`X`	`ENG`	`@0 Parkinson disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Parkinson enfermedad @5 01`
C03	`02`	`X`	`FRE`	`@0 Mouvement oculaire saccadé @5 02`
C03	`02`	`X`	`ENG`	`@0 Saccadic eye movement @5 02`
C03	`02`	`X`	`SPA`	`@0 Movimiento ocular brusco @5 02`
C03	`03`	`X`	`FRE`	`@0 Cortex frontal @5 03`
C03	`03`	`X`	`ENG`	`@0 Frontal cortex @5 03`
C03	`03`	`X`	`SPA`	`@0 Corteza frontal @5 03`
C03	`04`	`X`	`FRE`	`@0 Contrôle volontaire @5 05`
C03	`04`	`X`	`ENG`	`@0 Voluntary control @5 05`
C03	`04`	`X`	`SPA`	`@0 Control voluntario @5 05`
C03	`05`	`X`	`FRE`	`@0 Inhibition @5 06`
C03	`05`	`X`	`ENG`	`@0 Inhibition @5 06`
C03	`05`	`X`	`SPA`	`@0 Inhibición @5 06`
C03	`06`	`X`	`FRE`	`@0 Mémoire @5 07`
C03	`06`	`X`	`ENG`	`@0 Memory @5 07`
C03	`06`	`X`	`SPA`	`@0 Memoria @5 07`
C03	`07`	`X`	`FRE`	`@0 Noyau gris central @5 13`
C03	`07`	`X`	`ENG`	`@0 Basal ganglion @5 13`
C03	`07`	`X`	`SPA`	`@0 Núcleo basal @5 13`
C03	`08`	`X`	`FRE`	`@0 Homme @5 19`
C03	`08`	`X`	`ENG`	`@0 Human @5 19`
C03	`08`	`X`	`SPA`	`@0 Hombre @5 19`
C07	`01`	`X`	`FRE`	`@0 Système nerveux pathologie @5 37`
C07	`01`	`X`	`ENG`	`@0 Nervous system diseases @5 37`
C07	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Central nervous system disease @5 38`
C07	`02`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Encéphale pathologie @5 39`
C07	`03`	`X`	`ENG`	`@0 Cerebral disorder @5 39`
C07	`03`	`X`	`SPA`	`@0 Encéfalo patología @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Encéphale @5 45`
C07	`06`	`X`	`ENG`	`@0 Encephalon @5 45`
C07	`06`	`X`	`SPA`	`@0 Encéfalo @5 45`
C07	`07`	`X`	`FRE`	`@0 Système nerveux central @5 46`
C07	`07`	`X`	`ENG`	`@0 Central nervous system @5 46`
C07	`07`	`X`	`SPA`	`@0 Sistema nervioso central @5 46`
N21				`@1 108`
N44	`01`			`@1 PSI`
N82				`@1 PSI`

Format Inist (serveur)

NO :	PASCAL 05-0165101 INIST
ET :	Deficits in saccadic eye-movement control in Parkinson's disease
AU :	CHAN (Florence); ARMSTRONG (Irene T.); PARI (Giovanna); RIOPELLE (Richard J.); MUNOZ (Douglas P.)
AF :	Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Physiology, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (1 aut., 2 aut., 5 aut.); Department of Medicine, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (3 aut., 4 aut.); Department of Psychology, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2005; Vol. 43; No. 5; Pp. 784-796; Bibl. 2 p.1/4
LA :	Anglais
EA :	In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.
CC :	002B18C13; 002B17G
FD :	Parkinson maladie; Mouvement oculaire saccadé; Cortex frontal; Contrôle volontaire; Inhibition; Mémoire; Noyau gris central; Homme
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Système nerveux central
ED :	Parkinson disease; Saccadic eye movement; Frontal cortex; Voluntary control; Inhibition; Memory; Basal ganglion; Human
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Encephalon; Central nervous system
SD :	Parkinson enfermedad; Movimiento ocular brusco; Corteza frontal; Control voluntario; Inhibición; Memoria; Núcleo basal; Hombre
LO :	INIST-11143.354000125006590130
ID :	05-0165101

Links to Exploration step

Pascal:05-0165101

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Deficits in saccadic eye-movement control in Parkinson's disease</title>
<author><name sortKey="Chan, Florence" sort="Chan, Florence" uniqKey="Chan F" first="Florence" last="Chan">Florence Chan</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Armstrong, Irene T" sort="Armstrong, Irene T" uniqKey="Armstrong I" first="Irene T." last="Armstrong">Irene T. Armstrong</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pari, Giovanna" sort="Pari, Giovanna" uniqKey="Pari G" first="Giovanna" last="Pari">Giovanna Pari</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Riopelle, Richard J" sort="Riopelle, Richard J" uniqKey="Riopelle R" first="Richard J." last="Riopelle">Richard J. Riopelle</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Munoz, Douglas P" sort="Munoz, Douglas P" uniqKey="Munoz D" first="Douglas P." last="Munoz">Douglas P. Munoz</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Department of Psychology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0165101</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0165101 INIST</idno>
<idno type="RBID">Pascal:05-0165101</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000925</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deficits in saccadic eye-movement control in Parkinson's disease</title>
<author><name sortKey="Chan, Florence" sort="Chan, Florence" uniqKey="Chan F" first="Florence" last="Chan">Florence Chan</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Armstrong, Irene T" sort="Armstrong, Irene T" uniqKey="Armstrong I" first="Irene T." last="Armstrong">Irene T. Armstrong</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pari, Giovanna" sort="Pari, Giovanna" uniqKey="Pari G" first="Giovanna" last="Pari">Giovanna Pari</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Riopelle, Richard J" sort="Riopelle, Richard J" uniqKey="Riopelle R" first="Richard J." last="Riopelle">Richard J. Riopelle</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="03"><s1>Department of Medicine, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Munoz, Douglas P" sort="Munoz, Douglas P" uniqKey="Munoz D" first="Douglas P." last="Munoz">Douglas P. Munoz</name>
<affiliation><inist:fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="04"><s1>Department of Psychology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal ganglion</term>
<term>Frontal cortex</term>
<term>Human</term>
<term>Inhibition</term>
<term>Memory</term>
<term>Parkinson disease</term>
<term>Saccadic eye movement</term>
<term>Voluntary control</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Mouvement oculaire saccadé</term>
<term>Cortex frontal</term>
<term>Contrôle volontaire</term>
<term>Inhibition</term>
<term>Mémoire</term>
<term>Noyau gris central</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3932</s0>
</fA01>
<fA02 i1="01"><s0>NUPSA6</s0>
</fA02>
<fA03 i2="1"><s0>Neuropsychologia</s0>
</fA03>
<fA05><s2>43</s2>
</fA05>
<fA06><s2>5</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Deficits in saccadic eye-movement control in Parkinson's disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>CHAN (Florence)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>ARMSTRONG (Irene T.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>PARI (Giovanna)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>RIOPELLE (Richard J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MUNOZ (Douglas P.)</s1>
</fA11>
<fA14 i1="01"><s1>Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Physiology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Medicine, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Psychology, Centre for Neuroscience Studies, Queen's University</s1>
<s2>Kingston, Ont., K7L 3N6</s2>
<s3>CAN</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>784-796</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>11143</s2>
<s5>354000125006590130</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2005 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>2 p.1/4</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>05-0165101</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Neuropsychologia</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B18C13</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Mouvement oculaire saccadé</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Saccadic eye movement</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Movimiento ocular brusco</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Cortex frontal</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Frontal cortex</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Corteza frontal</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Contrôle volontaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Voluntary control</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Control voluntario</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Inhibition</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Inhibition</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Inhibición</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Mémoire</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Memory</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Memoria</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Human</s0>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0>
<s5>19</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>46</s5>
</fC07>
<fN21><s1>108</s1>
</fN21>
<fN44 i1="01"><s1>PSI</s1>
</fN44>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0165101 INIST</NO>
<ET>Deficits in saccadic eye-movement control in Parkinson's disease</ET>
<AU>CHAN (Florence); ARMSTRONG (Irene T.); PARI (Giovanna); RIOPELLE (Richard J.); MUNOZ (Douglas P.)</AU>
<AF>Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Physiology, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (1 aut., 2 aut., 5 aut.); Department of Medicine, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (3 aut., 4 aut.); Department of Psychology, Centre for Neuroscience Studies, Queen's University/Kingston, Ont., K7L 3N6/Canada (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2005; Vol. 43; No. 5; Pp. 784-796; Bibl. 2 p.1/4</SO>
<LA>Anglais</LA>
<EA>In contrast to their slowed limb movements, individuals with Parkinson's disease (PD) produce rapid automatic eye movements to sensory stimuli and show an impaired ability to generate voluntary eye movements in cognitive tasks. Eighteen PD patients and 18 matched control volunteers were instructed to look either toward (pro-saccade) or away from (anti-saccade) a peripheral stimulus as soon as it appeared (immediate, gap and overlap conditions) or after a variable delay; or, they made sequential saccades to remembered targets after a variable delay. We found that PD patients made more express saccades (correct saccades in the latency range of 90-140 ms) in the immediate pro-saccade task, more direction errors (automatic pro-saccades) in the immediate anti-saccade task, and were less able to inhibit saccades during the delay period in all delay tasks. PD patients also made more directional and end-point errors in the memory-guided sequential task. Their inability to plan eye movements to remembered target locations suggests that PD patients have a deficit in spatial working memory which, along with their deficit in automatic saccade suppression, is consistent with a disorder of the prefrontal-basal ganglia circuit. Impairment of this pathway may release the automatic saccade system from top-down inhibition and produce deficits in volitional saccade control. Parallel findings across various motor, cognitive and oculomotor tasks suggest a common mechanism underlying a general deficit in automatic response suppression.</EA>
<CC>002B18C13; 002B17G</CC>
<FD>Parkinson maladie; Mouvement oculaire saccadé; Cortex frontal; Contrôle volontaire; Inhibition; Mémoire; Noyau gris central; Homme</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Saccadic eye movement; Frontal cortex; Voluntary control; Inhibition; Memory; Basal ganglion; Human</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Movimiento ocular brusco; Corteza frontal; Control voluntario; Inhibición; Memoria; Núcleo basal; Hombre</SD>
<LO>INIST-11143.354000125006590130</LO>
<ID>05-0165101</ID>
</server>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000925 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000925 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PascalFrancis
   |étape=   Corpus
   |type=    RBID
   |clé=     Pascal:05-0165101
   |texte=   Deficits in saccadic eye-movement control in Parkinson's disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Deficits in saccadic eye-movement control in Parkinson's disease

Deficits in saccadic eye-movement control in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Notice en format standard (ISO 2709)

Format Inist (serveur)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri