ParkinsonCanadaV1, Main, Curation, bibRecord, 000C16

Abnormal metabolic network activity in REM sleep behavior disorder

Identifieur interne : 000C16 ( Main/Curation ); précédent : 000C15; suivant : 000C17

Abnormal metabolic network activity in REM sleep behavior disorder

Auteurs : Florian Holtbernd [États-Unis] ; Jean-François Gagnon [Canada] ; Ron B. Postuma [Canada] ; YILONG MA [États-Unis] ; Chris C. Tang [États-Unis] ; Andrew Feigin [États-Unis] ; Vijay Dhawan [États-Unis] ; Mélanie Vendette [Canada] ; Jean-Paul Soucy [Canada] ; David Eidelberg [États-Unis] ; Jacques Montplaisir [Canada]

Source :

Neurology [ 0028-3878 ] ; 2014.

RBID : Pascal:14-0077399

Descripteurs français

Pascal (Inist)
- Trouble du sommeil, Pathologie du système nerveux, Sommeil paradoxal, Comportement.

English descriptors

KwdEn :
- Aged, Behavior, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lewy Body Disease (complications), Lewy Body Disease (metabolism), Middle Aged, Multimodal Imaging, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (metabolism), Positron-Emission Tomography, Predictive Value of Tests, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (metabolism), Rapid eye movement sleep, Single-Blind Method, Sleep disorder, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
MESH :
- chemical : Fluorodeoxyglucose F18.
- complications : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- diagnosis : REM Sleep Behavior Disorder.
- metabolism : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Follow-Up Studies, Humans, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.

Abstract

Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with ¹⁸F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r² = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963420

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Le document en format XML

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<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Montreal</s1>
<s2>Montréal</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Behavior</term>
<term>Fluorodeoxyglucose F18</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lewy Body Disease (complications)</term>
<term>Lewy Body Disease (metabolism)</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM Sleep Behavior Disorder (diagnosis)</term>
<term>REM Sleep Behavior Disorder (metabolism)</term>
<term>Rapid eye movement sleep</term>
<term>Single-Blind Method</term>
<term>Sleep disorder</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Single-Blind Method</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term>
<term>Pathologie du   système nerveux</term>
<term>Sommeil paradoxal</term>
<term>Comportement</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</div>
</front>
</TEI>
<double idat="0028-3878:2014:Holtbernd F:abnormal:metabolic:network"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Abnormal metabolic network activity in REM sleep behavior disorder</title>
<author><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
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<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Montreal General Hospital</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Neurology, Montreal General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yilong Ma" sort="Yilong Ma" uniqKey="Yilong Ma" last="Yilong Ma">YILONG MA</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Montreal Neurological Institute, McGill University</s1>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Montreal</s1>
<s2>Montréal</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0077399</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0077399 INIST</idno>
<idno type="RBID">Pascal:14-0077399</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000035</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000B83</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000036</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000036</idno>
<idno type="wicri:doubleKey">0028-3878:2014:Holtbernd F:abnormal:metabolic:network</idno>
<idno type="wicri:Area/Main/Merge">000C21</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Abnormal metabolic network activity in REM sleep behavior disorder</title>
<author><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Montreal General Hospital</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Neurology, Montreal General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yilong Ma" sort="Yilong Ma" uniqKey="Yilong Ma" last="Yilong Ma">YILONG MA</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université du Québec à Montréal</orgName>
</affiliation>
</author>
<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Montreal Neurological Institute, McGill University</s1>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Manhasset, NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Montreal</s1>
<s2>Montréal</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term>
<term>Nervous system diseases</term>
<term>Rapid eye movement sleep</term>
<term>Sleep disorder</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term>
<term>Pathologie du   système nerveux</term>
<term>Sommeil paradoxal</term>
<term>Comportement</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</div>
</front>
</TEI>
</INIST>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Abnormal metabolic network activity in REM sleep behavior disorder</title>
<author><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name>
</author>
<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
</author>
<author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
</author>
<author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
</author>
<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
</author>
<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
</author>
<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24453082</idno>
<idno type="pmc">3963420</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963420</idno>
<idno type="RBID">PMC:3963420</idno>
<idno type="doi">10.1212/WNL.0000000000000130</idno>
<date when="2014">2014</date>
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<idno type="wicri:Area/Pmc/Checkpoint">000538</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000538</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000789</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000789</idno>
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<idno type="wicri:doubleKey">0028-3878:2014:Holtbernd F:abnormal:metabolic:network</idno>
<idno type="wicri:Area/Main/Merge">000B64</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Abnormal metabolic network activity in REM sleep behavior disorder</title>
<author><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name>
</author>
<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
</author>
<author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
</author>
<author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
</author>
<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
</author>
<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
</author>
<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
</author>
<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
</author>
<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
</author>
<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
</author>
</analytic>
<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2014">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Fluorodeoxyglucose F18</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Lewy Body Disease (complications)</term>
<term>Lewy Body Disease (metabolism)</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM Sleep Behavior Disorder (diagnosis)</term>
<term>REM Sleep Behavior Disorder (metabolism)</term>
<term>Single-Blind Method</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Single-Blind Method</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To determine whether the Parkinson disease–related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.</p>
</sec>
<sec><title>Methods:</title>
<p>For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.</p>
</sec>
<sec><title>Results:</title>
<p>PDRP expression was elevated in both groups of subjects with RBD (cohort 1: <italic>p</italic>
 < 0.04; cohort 2: <italic>p</italic>
 < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (<italic>r</italic>
<sup>2</sup>
 = 0.64, <italic>p</italic>
 < 0.0001).</p>
</sec>
<sec><title>Conclusions:</title>
<p>Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</p>
</sec>
</div>
</front>
</TEI>
</PMC>
</double>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Abnormal metabolic network activity in REM sleep behavior disorder

Abnormal metabolic network activity in REM sleep behavior disorder

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