Abnormal metabolic network activity in REM sleep behavior disorder.
Identifieur interne : 000789 ( PubMed/Corpus ); précédent : 000788; suivant : 000790Abnormal metabolic network activity in REM sleep behavior disorder.
Auteurs : Florian Holtbernd ; Jean-François Gagnon ; Ron B. Postuma ; Yilong Ma ; Chris C. Tang ; Andrew Feigin ; Vijay Dhawan ; Mélanie Vendette ; Jean-Paul Soucy ; David Eidelberg ; Jacques MontplaisirSource :
- Neurology [ 1526-632X ] ; 2014.
English descriptors
- KwdEn :
- Aged, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lewy Body Disease (complications), Lewy Body Disease (metabolism), Middle Aged, Multimodal Imaging, Parkinson Disease (complications), Parkinson Disease (metabolism), Positron-Emission Tomography, Predictive Value of Tests, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (metabolism), Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- MESH :
- chemical : Fluorodeoxyglucose F18.
- complications : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- diagnosis : REM Sleep Behavior Disorder.
- metabolism : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Follow-Up Studies, Humans, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
Abstract
To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.
DOI: 10.1212/WNL.0000000000000130
PubMed: 24453082
Links to Exploration step
pubmed:24453082Le document en format XML
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Postuma</name></author><author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name></author><author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C" last="Tang">Chris C. Tang</name></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name></author><author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24453082</idno><idno type="pmid">24453082</idno><idno type="doi">10.1212/WNL.0000000000000130</idno><idno type="wicri:Area/PubMed/Corpus">000789</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000789</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Abnormal metabolic network activity in REM sleep behavior disorder.</title><author><name sortKey="Holtbernd, Florian" sort="Holtbernd, Florian" uniqKey="Holtbernd F" first="Florian" last="Holtbernd">Florian Holtbernd</name><affiliation><nlm:affiliation>From the Center for Neurosciences (F.H., Y.M., C.C.T., A.F., V.D., D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; Center for Advanced Research in Sleep Medicine (J.-F.G., R.B.P., M.V., J.M.), Hôpital du Sacré-Coeur de Montréal; Department of Psychology (J.-F.G., M.V.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Montreal Neurological Institute (J.-P.S.), McGill University; and Department of Psychiatry (J.M.), University of Montreal, Montréal, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name></author><author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B" last="Postuma">Ron B. Postuma</name></author><author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name></author><author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C" last="Tang">Chris C. Tang</name></author><author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name></author><author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name></author><author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Fluorodeoxyglucose F18</term><term>Follow-Up Studies</term><term>Humans</term><term>Lewy Body Disease (complications)</term><term>Lewy Body Disease (metabolism)</term><term>Middle Aged</term><term>Multimodal Imaging</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (metabolism)</term><term>Positron-Emission Tomography</term><term>Predictive Value of Tests</term><term>REM Sleep Behavior Disorder (complications)</term><term>REM Sleep Behavior Disorder (diagnosis)</term><term>REM Sleep Behavior Disorder (metabolism)</term><term>Single-Blind Method</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lewy Body Disease</term><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lewy Body Disease</term><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Multimodal Imaging</term><term>Positron-Emission Tomography</term><term>Predictive Value of Tests</term><term>Single-Blind Method</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24453082</PMID><DateCreated><Year>2014</Year><Month>02</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>82</Volume><Issue>7</Issue><PubDate><Year>2014</Year><Month>Feb</Month><Day>18</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Abnormal metabolic network activity in REM sleep behavior disorder.</ArticleTitle><Pagination><MedlinePgn>620-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000000130</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with (18)F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r(2) = 0.64, p < 0.0001).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Holtbernd</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>From the Center for Neurosciences (F.H., Y.M., C.C.T., A.F., V.D., D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; Center for Advanced Research in Sleep Medicine (J.-F.G., R.B.P., M.V., J.M.), Hôpital du Sacré-Coeur de Montréal; Department of Psychology (J.-F.G., M.V.), Université du Québec à Montréal; Department of Neurology (R.B.P.), Montreal General Hospital; Montreal Neurological Institute (J.-P.S.), McGill University; and Department of Psychiatry (J.M.), University of Montreal, Montréal, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gagnon</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>Ron B</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Yilong</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Chris C</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Feigin</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dhawan</LastName><ForeName>Vijay</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Vendette</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Soucy</LastName><ForeName>Jean-Paul</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Eidelberg</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Montplaisir</LastName><ForeName>Jacques</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P50 NS071675</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain. 2000 Jun;123 ( Pt 6):1155-60</RefSource><PMID Version="1">10825354</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Vis Exp. 2013;(76). doi: 10.3791/50319</RefSource><PMID Version="1">23851955</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurobiol Aging. 2003 Mar-Apr;24(2):197-211</RefSource><PMID 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MajorTopicYN="N">Lewy Body Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064847" MajorTopicYN="N">Multimodal Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020187" MajorTopicYN="N">REM Sleep Behavior Disorder</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016037" MajorTopicYN="N">Single-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015899" MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3963420</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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