Abnormal metabolic network activity in REM sleep behavior disorder
Identifieur interne : 001669 ( Ncbi/Curation ); précédent : 001668; suivant : 001670Abnormal metabolic network activity in REM sleep behavior disorder
Auteurs : Florian Holtbernd ; Jean-François Gagnon ; Ron B. Postuma ; Yilong Ma ; Chris C. Tang ; Andrew Feigin ; Vijay Dhawan ; Mélanie Vendette ; Jean-Paul Soucy ; David Eidelberg ; Jacques MontplaisirSource :
- Neurology [ 0028-3878 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Lewy Body Disease (complications), Lewy Body Disease (metabolism), Middle Aged, Multimodal Imaging, Parkinson Disease (complications), Parkinson Disease (metabolism), Positron-Emission Tomography, Predictive Value of Tests, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (metabolism), Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- MESH :
- chemical : Fluorodeoxyglucose F18.
- complications : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- diagnosis : REM Sleep Behavior Disorder.
- metabolism : Lewy Body Disease, Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Follow-Up Studies, Humans, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Predictive Value of Tests, Single-Blind Method, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
Abstract
To determine whether the Parkinson disease–related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.
For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with 18F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.
PDRP expression was elevated in both groups of subjects with RBD (cohort 1:
Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.
Url:
DOI: 10.1212/WNL.0000000000000130
PubMed: 24453082
PubMed Central: 3963420
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PMC:3963420Le document en format XML
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<author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name>
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<author><name sortKey="Postuma, Ron B" sort="Postuma, Ron B" uniqKey="Postuma R" first="Ron B." last="Postuma">Ron B. Postuma</name>
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<author><name sortKey="Ma, Yilong" sort="Ma, Yilong" uniqKey="Ma Y" first="Yilong" last="Ma">Yilong Ma</name>
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<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
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<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
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<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
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<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
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<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
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<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
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<term>Lewy Body Disease (complications)</term>
<term>Lewy Body Disease (metabolism)</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM Sleep Behavior Disorder (diagnosis)</term>
<term>REM Sleep Behavior Disorder (metabolism)</term>
<term>Single-Blind Method</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tomography, X-Ray Computed</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term>
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<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
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<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
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<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Multimodal Imaging</term>
<term>Positron-Emission Tomography</term>
<term>Predictive Value of Tests</term>
<term>Single-Blind Method</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To determine whether the Parkinson disease–related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.</p>
</sec>
<sec><title>Methods:</title>
<p>For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.</p>
</sec>
<sec><title>Results:</title>
<p>PDRP expression was elevated in both groups of subjects with RBD (cohort 1: <italic>p</italic>
< 0.04; cohort 2: <italic>p</italic>
< 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (<italic>r</italic>
<sup>2</sup>
= 0.64, <italic>p</italic>
< 0.0001).</p>
</sec>
<sec><title>Conclusions:</title>
<p>Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</p>
</sec>
</div>
</front>
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