ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000035

Abnormal metabolic network activity in REM sleep behavior disorder

Identifieur interne : 000035 ( PascalFrancis/Corpus ); précédent : 000034; suivant : 000036

Abnormal metabolic network activity in REM sleep behavior disorder

Auteurs : Florian Holtbernd ; Jean-François Gagnon ; Ron B. Postuma ; YILONG MA ; Chris C. Tang ; Andrew Feigin ; Vijay Dhawan ; Mélanie Vendette ; Jean-Paul Soucy ; David Eidelberg ; Jacques Montplaisir

Source :

Neurology [ 0028-3878 ] ; 2014.

RBID : Pascal:14-0077399

Descripteurs français

Pascal (Inist)
- Trouble du sommeil, Pathologie du système nerveux, Sommeil paradoxal, Comportement.

English descriptors

KwdEn :
- Behavior, Nervous system diseases, Rapid eye movement sleep, Sleep disorder.

Abstract

Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with ¹⁸F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r² = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 NEURAI`
A03		`1`		`@0 Neurology`
A05				`@2 82`
A06				`@2 7`
A08	`01`	`1`	`ENG`	`@1 Abnormal metabolic network activity in REM sleep behavior disorder`
A11	`01`	`1`		`@1 HOLTBERND (Florian)`
A11	`02`	`1`		`@1 GAGNON (Jean-François)`
A11	`03`	`1`		`@1 POSTUMA (Ron B.)`
A11	`04`	`1`		`@1 YILONG MA`
A11	`05`	`1`		`@1 TANG (Chris C.)`
A11	`06`	`1`		`@1 FEIGIN (Andrew)`
A11	`07`	`1`		`@1 DHAWAN (Vijay)`
A11	`08`	`1`		`@1 VENDETTE (Mélanie)`
A11	`09`	`1`		`@1 SOUCY (Jean-Paul)`
A11	`10`	`1`		`@1 EIDELBERG (David)`
A11	`11`	`1`		`@1 MONTPLAISIR (Jacques)`
A14	`01`			`@1 Center for Neurosciences, The Feinstein Institute for Medical Research @2 Manhasset, NY @3 USA @Z 1 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut. @Z 7 aut. @Z 10 aut.`
A14	`02`			`@1 Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal @3 CAN @Z 2 aut. @Z 8 aut. @Z 11 aut.`
A14	`03`			`@1 Department of Psychology, Université du Québec à Montréal @3 CAN @Z 2 aut. @Z 8 aut.`
A14	`04`			`@1 Department of Neurology, Montreal General Hospital @3 CAN @Z 3 aut.`
A14	`05`			`@1 Montreal Neurological Institute, McGill University @3 CAN @Z 9 aut.`
A14	`06`			`@1 Department of Psychiatry, University of Montreal @2 Montréal @3 CAN @Z 11 aut.`
A20				`@1 620-627`
A21				`@1 2014`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6345 @5 354000501138450120`
A44				`@0 0000 @1 © 2014 INIST-CNRS. All rights reserved.`
A45				`@0 33 ref.`
A47	`01`	`1`		`@0 14-0077399`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Neurology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with ¹⁸F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r² = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.
C02	`01`	`X`		`@0 002B17A02`
C02	`02`	`X`		`@0 002A25K`
C03	`01`	`X`	`FRE`	`@0 Trouble du sommeil @5 01`
C03	`01`	`X`	`ENG`	`@0 Sleep disorder @5 01`
C03	`01`	`X`	`SPA`	`@0 Trastorno sueño @5 01`
C03	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 02`
C03	`02`	`X`	`ENG`	`@0 Nervous system diseases @5 02`
C03	`02`	`X`	`SPA`	`@0 Sistema nervioso patología @5 02`
C03	`03`	`X`	`FRE`	`@0 Sommeil paradoxal @5 09`
C03	`03`	`X`	`ENG`	`@0 Rapid eye movement sleep @5 09`
C03	`03`	`X`	`SPA`	`@0 Sueño paradojal @5 09`
C03	`04`	`X`	`FRE`	`@0 Comportement @5 10`
C03	`04`	`X`	`ENG`	`@0 Behavior @5 10`
C03	`04`	`X`	`SPA`	`@0 Conducta @5 10`
C07	`01`	`X`	`FRE`	`@0 Cycle veille sommeil @5 37`
C07	`01`	`X`	`ENG`	`@0 Sleep wake cycle @5 37`
C07	`01`	`X`	`SPA`	`@0 Ciclo sueño vigilia @5 37`
C07	`02`	`X`	`FRE`	`@0 Trouble neurologique @5 39`
C07	`02`	`X`	`ENG`	`@0 Neurological disorder @5 39`
C07	`02`	`X`	`SPA`	`@0 Trastorno neurológico @5 39`
N21				`@1 104`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 14-0077399 INIST
ET :	Abnormal metabolic network activity in REM sleep behavior disorder
AU :	HOLTBERND (Florian); GAGNON (Jean-François); POSTUMA (Ron B.); YILONG MA; TANG (Chris C.); FEIGIN (Andrew); DHAWAN (Vijay); VENDETTE (Mélanie); SOUCY (Jean-Paul); EIDELBERG (David); MONTPLAISIR (Jacques)
AF :	Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, NY/Etats-Unis (1 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal/Canada (2 aut., 8 aut., 11 aut.); Department of Psychology, Université du Québec à Montréal/Canada (2 aut., 8 aut.); Department of Neurology, Montreal General Hospital/Canada (3 aut.); Montreal Neurological Institute, McGill University/Canada (9 aut.); Department of Psychiatry, University of Montreal/Montréal/Canada (11 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2014; Vol. 82; No. 7; Pp. 620-627; Bibl. 33 ref.
LA :	Anglais
EA :	Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with ¹⁸F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r² = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.
CC :	002B17A02; 002A25K
FD :	Trouble du sommeil; Pathologie du système nerveux; Sommeil paradoxal; Comportement
FG :	Cycle veille sommeil; Trouble neurologique
ED :	Sleep disorder; Nervous system diseases; Rapid eye movement sleep; Behavior
EG :	Sleep wake cycle; Neurological disorder
SD :	Trastorno sueño; Sistema nervioso patología; Sueño paradojal; Conducta
LO :	INIST-6345.354000501138450120
ID :	14-0077399

Links to Exploration step

Pascal:14-0077399

Le document en format XML

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<author><name sortKey="Yilong Ma" sort="Yilong Ma" uniqKey="Yilong Ma" last="Yilong Ma">YILONG MA</name>
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<author><name sortKey="Tang, Chris C" sort="Tang, Chris C" uniqKey="Tang C" first="Chris C." last="Tang">Chris C. Tang</name>
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<author><name sortKey="Feigin, Andrew" sort="Feigin, Andrew" uniqKey="Feigin A" first="Andrew" last="Feigin">Andrew Feigin</name>
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<author><name sortKey="Dhawan, Vijay" sort="Dhawan, Vijay" uniqKey="Dhawan V" first="Vijay" last="Dhawan">Vijay Dhawan</name>
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<author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
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<affiliation><inist:fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
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<sZ>8 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name>
<affiliation><inist:fA14 i1="05"><s1>Montreal Neurological Institute, McGill University</s1>
<s3>CAN</s3>
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</inist:fA14>
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</author>
<author><name sortKey="Eidelberg, David" sort="Eidelberg, David" uniqKey="Eidelberg D" first="David" last="Eidelberg">David Eidelberg</name>
<affiliation><inist:fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
<s2>Manhasset, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
<affiliation><inist:fA14 i1="02"><s1>Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal</s1>
<s3>CAN</s3>
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<affiliation><inist:fA14 i1="06"><s1>Department of Psychiatry, University of Montreal</s1>
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<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2014">2014</date>
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<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term>
<term>Nervous system diseases</term>
<term>Rapid eye movement sleep</term>
<term>Sleep disorder</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term>
<term>Pathologie du   système nerveux</term>
<term>Sommeil paradoxal</term>
<term>Comportement</term>
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<front><div type="abstract" xml:lang="en">Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</div>
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<fA11 i1="02" i2="1"><s1>GAGNON (Jean-François)</s1>
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<fA11 i1="03" i2="1"><s1>POSTUMA (Ron B.)</s1>
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<fA11 i1="04" i2="1"><s1>YILONG MA</s1>
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<fA14 i1="01"><s1>Center for Neurosciences, The Feinstein Institute for Medical Research</s1>
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<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
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<sZ>6 aut.</sZ>
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<sZ>8 aut.</sZ>
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<fA14 i1="03"><s1>Department of Psychology, Université du Québec à Montréal</s1>
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<fA14 i1="06"><s1>Department of Psychiatry, University of Montreal</s1>
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<fC01 i1="01" l="ENG"><s0>Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</s0>
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<server><NO>PASCAL 14-0077399 INIST</NO>
<ET>Abnormal metabolic network activity in REM sleep behavior disorder</ET>
<AU>HOLTBERND (Florian); GAGNON (Jean-François); POSTUMA (Ron B.); YILONG MA; TANG (Chris C.); FEIGIN (Andrew); DHAWAN (Vijay); VENDETTE (Mélanie); SOUCY (Jean-Paul); EIDELBERG (David); MONTPLAISIR (Jacques)</AU>
<AF>Center for Neurosciences, The Feinstein Institute for Medical Research/Manhasset, NY/Etats-Unis (1 aut., 4 aut., 5 aut., 6 aut., 7 aut., 10 aut.); Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal/Canada (2 aut., 8 aut., 11 aut.); Department of Psychology, Université du Québec à Montréal/Canada (2 aut., 8 aut.); Department of Neurology, Montreal General Hospital/Canada (3 aut.); Montreal Neurological Institute, McGill University/Canada (9 aut.); Department of Psychiatry, University of Montreal/Montréal/Canada (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2014; Vol. 82; No. 7; Pp. 620-627; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion. Methods: For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 ± 9.4 years old) and 10 healthy volunteers (62.7 ± 8.6 years old) who underwent resting-state metabolic brain imaging with <sup>18</sup>
F-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 ± 4.8 years old) and 17 healthy volunteers (66.6 ± 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 ± 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values. Results: PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r<sup>2</sup>
 = 0.64, p < 0.0001). Conclusions: Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.</EA>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Abnormal metabolic network activity in REM sleep behavior disorder

Abnormal metabolic network activity in REM sleep behavior disorder

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