Micro-to-nano biomechanical modeling for assisted biological cell injection.
Identifieur interne : 001A32 ( Main/Exploration ); précédent : 001A31; suivant : 001A33Micro-to-nano biomechanical modeling for assisted biological cell injection.
Auteurs : Hamid Ladjal [France] ; Jean-Luc Hanus ; Antoine FerreiraSource :
- IEEE transactions on bio-medical engineering [ 1558-2531 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Biomechanical Phenomena, Cell Physiological Phenomena, Cytoskeleton (physiology), Finite Element Analysis, Mice, Microinjections, Models, Biological, Nanotechnology (instrumentation), Nanotechnology (methods), Oocytes (cytology), Oocytes (physiology), Pressure, Single-Cell Analysis (methods).
- MESH :
- cytology : Oocytes.
- instrumentation : Nanotechnology.
- methods : Nanotechnology, Single-Cell Analysis.
- physiology : Cytoskeleton, Oocytes.
- Animals, Biomechanical Phenomena, Cell Physiological Phenomena, Finite Element Analysis, Mice, Microinjections, Models, Biological, Pressure.
- mix :
Abstract
To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display, and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules, and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite-element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St, Venant-Kirchhoff). Both graphic and haptic rendering are provided in real time to the operator through a 3-D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically based model.
Url:
DOI: 10.1109/TBME.2013.2258155
PubMed: 23613019
Affiliations:
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Le document en format XML
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xml:lang="en"><term>Biomechanics</term><term>cell injection</term><term>finite element modeling</term><term>haptic interaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display, and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules, and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite-element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St, Venant-Kirchhoff). Both graphic and haptic rendering are provided in real time to the operator through a 3-D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically based model.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><orgName><li>Université Claude Bernard Lyon1</li></orgName></list><tree><noCountry><name sortKey="Ferreira, Antoine" sort="Ferreira, Antoine" uniqKey="Ferreira A" first="Antoine" last="Ferreira">Antoine Ferreira</name><name sortKey="Hanus, Jean Luc" sort="Hanus, Jean Luc" uniqKey="Hanus J" first="Jean-Luc" last="Hanus">Jean-Luc Hanus</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ladjal, Hamid" sort="Ladjal, Hamid" uniqKey="Ladjal H" first="Hamid" last="Ladjal">Hamid Ladjal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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