Micro-to-nano biomechanical modeling for assisted biological cell injection.
Identifieur interne : 000969 ( PubMed/Curation ); précédent : 000968; suivant : 000970Micro-to-nano biomechanical modeling for assisted biological cell injection.
Auteurs : Hamid Ladjal [France] ; Jean-Luc Hanus ; Antoine FerreiraSource :
- IEEE transactions on bio-medical engineering [ 1558-2531 ] ; 2013.
English descriptors
- KwdEn :
- Animals, Biomechanical Phenomena, Cell Physiological Phenomena, Cytoskeleton (physiology), Finite Element Analysis, Mice, Microinjections, Models, Biological, Nanotechnology (instrumentation), Nanotechnology (methods), Oocytes (cytology), Oocytes (physiology), Pressure, Single-Cell Analysis (methods).
- MESH :
- cytology : Oocytes.
- instrumentation : Nanotechnology.
- methods : Nanotechnology, Single-Cell Analysis.
- physiology : Cytoskeleton, Oocytes.
- Animals, Biomechanical Phenomena, Cell Physiological Phenomena, Finite Element Analysis, Mice, Microinjections, Models, Biological, Pressure.
Abstract
To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display, and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules, and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite-element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St, Venant-Kirchhoff). Both graphic and haptic rendering are provided in real time to the operator through a 3-D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically based model.
DOI: 10.1109/TBME.2013.2258155
PubMed: 23613019
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This paper presents methodologies for dynamic modeling, visual/haptic display, and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules, and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite-element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St, Venant-Kirchhoff). Both graphic and haptic rendering are provided in real time to the operator through a 3-D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically based model.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23613019</PMID><DateCreated><Year>2013</Year><Month>08</Month><Day>21</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>28</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1558-2531</ISSN><JournalIssue CitedMedium="Internet"><Volume>60</Volume><Issue>9</Issue><PubDate><Year>2013</Year><Month>Sep</Month></PubDate></JournalIssue><Title>IEEE transactions on bio-medical engineering</Title><ISOAbbreviation>IEEE Trans Biomed Eng</ISOAbbreviation></Journal><ArticleTitle>Micro-to-nano biomechanical modeling for assisted biological cell injection.</ArticleTitle><Pagination><MedlinePgn>2461-71</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1109/TBME.2013.2258155</ELocationID><Abstract><AbstractText>To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. 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