Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection
Identifieur interne : 000126 ( Hal/Checkpoint ); précédent : 000125; suivant : 000127Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection
Auteurs : Hamid Ladjal [France] ; Jean-Luc Hanus [France] ; Antoine Ferreira [France]Source :
- IEEE Transactions on Biomedical Engineering [ 0018-9294 ] ; 2013-09-06.
English descriptors
Abstract
To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.
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DOI: 10.1109/TBME.2013.2258155
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Hal:hal-00821621Le document en format XML
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<front><div type="abstract" xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.</div>
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<abstract xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.</abstract>
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