Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection
Identifieur interne : 000126 ( Hal/Checkpoint ); précédent : 000125; suivant : 000127Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection
Auteurs : Hamid Ladjal [France] ; Jean-Luc Hanus [France] ; Antoine Ferreira [France]Source :
- IEEE Transactions on Biomedical Engineering [ 0018-9294 ] ; 2013-09-06.
English descriptors
Abstract
To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.
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DOI: 10.1109/TBME.2013.2258155
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Avenue du Parc Floral - BP 6749 - 45067 Orléans cedex 2</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-orleans.fr/</ref></desc></org></tutelle><tutelle active="#struct-302160" type="indirect"><org type="institution" xml:id="struct-302160" status="VALID"><orgName>ENSI Bourges</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Orléans</settlement><region type="old region" nuts="2">Région Centre</region><region type="region" nuts="2">Centre-Val de Loire</region></placeName><orgName type="university">Université d'Orléans</orgName><orgName type="institution" wicri:auto="newGroup">Centre Val de Loire Université</orgName></affiliation></author></analytic><idno type="DOI">10.1109/TBME.2013.2258155</idno><series><title level="j">IEEE Transactions on Biomedical Engineering</title><idno type="ISSN">0018-9294</idno><imprint><date type="datePub">2013-09-06</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Biomechanics</term><term>cell injection</term><term>finite element modeling</term><term>haptic interaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="en">Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection</title><author role="aut"><persName><forename type="first">Hamid</forename><surname>Ladjal</surname></persName><email>hamid.ladjal@liris.cnrs.fr</email><idno type="idhal">hamid-ladjal</idno><idno type="halauthor">671697</idno><affiliation ref="#struct-396668"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Luc</forename><surname>Hanus</surname></persName><email>Jean-luc.Hanus@ensi-bourges.fr</email><idno type="halauthor">666132</idno><affiliation ref="#struct-396669"></affiliation></author><author role="crp"><persName><forename type="first">Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email><idno type="halauthor">666129</idno><affiliation ref="#struct-392466"></affiliation></author><editor role="depositor"><persName><forename>Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email></editor><funder>Bourse CIFRE</funder></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2013-05-22 17:45:49</date><date type="whenWritten">2013-05-01</date><date type="whenModified">2016-03-22 01:24:19</date><date type="whenReleased">2013-05-23 08:35:58</date><date type="whenProduced">2013-09-06</date><date type="whenEndEmbargoed">2013-05-22</date><ref type="file" target="https://hal.archives-ouvertes.fr/hal-00821621/document"><date notBefore="2013-05-22"></date></ref><ref type="file" subtype="author" n="1" target="https://hal.archives-ouvertes.fr/hal-00821621/file/TBME_Cell_modeling_07_04_2013.pdf"><date notBefore="2013-05-22"></date></ref></edition><respStmt><resp>contributor</resp><name key="163161"><persName><forename>Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">hal-00821621</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00821621</idno><idno type="halBibtex">ladjal:hal-00821621</idno><idno type="halRefHtml">IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, 2013, Vol.99 (N.99), pp.1-11. <10.1109/TBME.2013.2258155></idno><idno type="halRef">IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, 2013, Vol.99 (N.99), pp.1-11. <10.1109/TBME.2013.2258155></idno></publicationStmt><seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="UNIV-LYON2">Université Lumière Lyon 2</idno><idno type="stamp" n="UNIV-ORLEANS">Université d'Orléans</idno><idno type="stamp" n="EC-LYON">Ecole Centrale de Lyon</idno><idno type="stamp" n="LIRIS">Laboratoire d'InfoRmatique en Image et Systèmes d'information</idno><idno type="stamp" n="MSL">Modelisation Systemes Langages</idno><idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno><idno type="stamp" n="PRIMES_WP5" p="PRIMES">WP5: Simulation et modélisation d'images</idno><idno type="stamp" n="MSL-THESE">Modelisation Systemes Langages</idno><idno type="stamp" n="TDS-MACS">Réseau de recherche en Théorie des Systèmes Distribués, Modélisation, Analyse et Contrôle des Systèmes</idno></seriesStmt><notesStmt><note type="audience" n="2">International</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell Injection</title><author role="aut"><persName><forename type="first">Hamid</forename><surname>Ladjal</surname></persName><email>hamid.ladjal@liris.cnrs.fr</email><idno type="idHal">hamid-ladjal</idno><idno type="halAuthorId">671697</idno><affiliation ref="#struct-396668"></affiliation></author><author role="aut"><persName><forename type="first">Jean-Luc</forename><surname>Hanus</surname></persName><email>Jean-luc.Hanus@ensi-bourges.fr</email><idno type="halAuthorId">666132</idno><affiliation ref="#struct-396669"></affiliation></author><author role="crp"><persName><forename type="first">Antoine</forename><surname>Ferreira</surname></persName><email>antoine.ferreira@ensi-bourges.fr</email><idno type="halAuthorId">666129</idno><affiliation ref="#struct-392466"></affiliation></author></analytic><monogr><idno type="localRef">ROB et DMS</idno><idno type="halJournalId" status="VALID">5359</idno><idno type="issn">0018-9294</idno><title level="j">IEEE Transactions on Biomedical Engineering</title><imprint><publisher>Institute of Electrical and Electronics Engineers</publisher><biblScope unit="volume">Vol.99</biblScope><biblScope unit="issue">N.99</biblScope><biblScope unit="pp">1-11</biblScope><date type="datePub">2013-09-06</date></imprint></monogr><idno type="doi">10.1109/TBME.2013.2258155</idno></biblStruct></sourceDesc><profileDesc><langUsage><language ident="en">English</language></langUsage><textClass><keywords scheme="author"><term xml:lang="en">Biomechanics</term><term xml:lang="en">cell injection</term><term xml:lang="en">finite element modeling</term><term xml:lang="en">haptic interaction</term></keywords><classCode scheme="halDomain" n="spi.auto">Engineering Sciences [physics]/Automatic</classCode><classCode scheme="halTypology" n="ART">Journal articles</classCode></textClass><abstract xml:lang="en">To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual/haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model (St-Venant-Kirchhoff). Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.</abstract><particDesc><org type="consortium">Centre de Recherche en Biologie de Baugy</org></particDesc></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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