Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging.
Identifieur interne : 000622 ( Ncbi/Checkpoint ); précédent : 000621; suivant : 000623Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging.
Auteurs : Yang Yang [République populaire de Chine] ; Yun Sun ; Tianye Cao ; Juanjuan Peng ; Ying Liu ; Yongquan Wu ; Wei Feng ; Yingjian Zhang ; Fuyou LiSource :
- Biomaterials [ 1878-5905 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Composés du fluor (), Composés du fluor (pharmacocinétique), Composés du fluor (toxicité), Humains, Imagerie optique (), Lignée cellulaire tumorale, Luminescence, Lutétium (), Lutétium (pharmacocinétique), Lutétium (toxicité), Mesures de luminescence (), Nanoparticules (analyse), Nanoparticules (toxicité), Nanoparticules (ultrastructure), Radio-isotopes (), Radio-isotopes (pharmacocinétique), Radio-isotopes (toxicité), Répartition dans les tissus, Samarium (), Samarium (pharmacocinétique), Samarium (toxicité), Sodium (), Sodium (pharmacocinétique), Sodium (toxicité), Souris, Thulium (), Thulium (pharmacocinétique), Thulium (toxicité), Tomographie par émission monophotonique (), Ytterbium (), Ytterbium (pharmacocinétique), Ytterbium (toxicité).
- MESH :
- analyse : Nanoparticules.
- pharmacocinétique : Composés du fluor, Lutétium, Radio-isotopes, Samarium, Sodium, Thulium, Ytterbium.
- toxicité : Composés du fluor, Lutétium, Nanoparticules, Radio-isotopes, Samarium, Sodium, Thulium, Ytterbium.
- Animaux, Composés du fluor, Humains, Imagerie optique, Lignée cellulaire tumorale, Luminescence, Lutétium, Mesures de luminescence, Nanoparticules, Radio-isotopes, Répartition dans les tissus, Samarium, Sodium, Souris, Thulium, Tomographie par émission monophotonique, Ytterbium.
English descriptors
- KwdEn :
- Animals, Cell Line, Tumor, Fluorine Compounds (chemistry), Fluorine Compounds (pharmacokinetics), Fluorine Compounds (toxicity), Humans, Luminescence, Luminescent Measurements (methods), Lutetium (chemistry), Lutetium (pharmacokinetics), Lutetium (toxicity), Mice, Nanoparticles (analysis), Nanoparticles (toxicity), Nanoparticles (ultrastructure), Optical Imaging (methods), Radioisotopes (chemistry), Radioisotopes (pharmacokinetics), Radioisotopes (toxicity), Samarium (chemistry), Samarium (pharmacokinetics), Samarium (toxicity), Sodium (chemistry), Sodium (pharmacokinetics), Sodium (toxicity), Thulium (chemistry), Thulium (pharmacokinetics), Thulium (toxicity), Tissue Distribution, Tomography, Emission-Computed, Single-Photon (methods), Ytterbium (chemistry), Ytterbium (pharmacokinetics), Ytterbium (toxicity).
- MESH :
- chemical , chemistry : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- chemical , pharmacokinetics : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- chemical , toxicity : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- analysis : Nanoparticles.
- methods : Luminescent Measurements, Optical Imaging, Tomography, Emission-Computed, Single-Photon.
- toxicity : Nanoparticles.
- ultrastructure : Nanoparticles.
- Animals, Cell Line, Tumor, Humans, Luminescence, Mice, Tissue Distribution.
Abstract
Upconversion luminescence (UCL) properties and radioactivity have been integrated into NaLuF(4):(153)Sm,Yb,Tm nanoparticles by a facile one-step hydrothermal method, making these nanoparticles potential candidates for UCL and single-photon emission computed tomography (SPECT) dual-modal bioimaging in vivo. The introduction of small amount of radioactive (153)Sm(3+) can hardly vary the upconversion luminescence properties of the nanoparticles. The as-designed nanoparticles showed very low cytotoxicity, no obvious tissue damage in 7 days, and excellent in vitro and in vivo performances in dual-modal bioimaging. By means of a combination of UCL and SPECT imaging in vivo, the distribution of the nanoparticles in living animals has been studied, and the results indicated that these particles were mainly accumulated in the liver and spleen. Therefore, the concept of (153)Sm(3+)/Yb(3+)/Tm(3+) co-doped NaLuF(4) nanoparticles for UCL and SPECT dual-modality imaging in vivo of whole-body animals may serve as a platform for next-generation probes for ultra-sensitive molecular imaging from the cellular scale to whole-body evaluation. It also introduces an easy methodology to quantify in vivo biodistribution of nanomaterials which still needs further understanding as a community.
DOI: 10.1016/j.biomaterials.2012.10.022
PubMed: 23117216
Affiliations:
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pubmed:23117216Le document en format XML
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Cao</name></author><author><name sortKey="Peng, Juanjuan" sort="Peng, Juanjuan" uniqKey="Peng J" first="Juanjuan" last="Peng">Juanjuan Peng</name></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name></author><author><name sortKey="Wu, Yongquan" sort="Wu, Yongquan" uniqKey="Wu Y" first="Yongquan" last="Wu">Yongquan Wu</name></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name></author><author><name sortKey="Zhang, Yingjian" sort="Zhang, Yingjian" uniqKey="Zhang Y" first="Yingjian" last="Zhang">Yingjian Zhang</name></author><author><name sortKey="Li, Fuyou" sort="Li, Fuyou" uniqKey="Li F" first="Fuyou" last="Li">Fuyou Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="doi">10.1016/j.biomaterials.2012.10.022</idno><idno type="RBID">pubmed:23117216</idno><idno type="pmid">23117216</idno><idno 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Institute of Biomedical Science, Fudan University, 220 Handan Road, Shanghai, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chemistry & Institute of Biomedical Science, Fudan University, 220 Handan Road, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yun" sort="Sun, Yun" uniqKey="Sun Y" first="Yun" last="Sun">Yun Sun</name></author><author><name sortKey="Cao, Tianye" sort="Cao, Tianye" uniqKey="Cao T" first="Tianye" last="Cao">Tianye Cao</name></author><author><name sortKey="Peng, Juanjuan" sort="Peng, Juanjuan" uniqKey="Peng J" first="Juanjuan" last="Peng">Juanjuan Peng</name></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name></author><author><name sortKey="Wu, Yongquan" sort="Wu, Yongquan" uniqKey="Wu Y" first="Yongquan" last="Wu">Yongquan Wu</name></author><author><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name></author><author><name sortKey="Zhang, Yingjian" sort="Zhang, Yingjian" uniqKey="Zhang Y" first="Yingjian" last="Zhang">Yingjian Zhang</name></author><author><name sortKey="Li, Fuyou" sort="Li, Fuyou" uniqKey="Li F" first="Fuyou" last="Li">Fuyou Li</name></author></analytic><series><title level="j">Biomaterials</title><idno type="eISSN">1878-5905</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Fluorine Compounds (chemistry)</term><term>Fluorine Compounds (pharmacokinetics)</term><term>Fluorine Compounds (toxicity)</term><term>Humans</term><term>Luminescence</term><term>Luminescent Measurements (methods)</term><term>Lutetium (chemistry)</term><term>Lutetium (pharmacokinetics)</term><term>Lutetium (toxicity)</term><term>Mice</term><term>Nanoparticles (analysis)</term><term>Nanoparticles (toxicity)</term><term>Nanoparticles (ultrastructure)</term><term>Optical Imaging (methods)</term><term>Radioisotopes (chemistry)</term><term>Radioisotopes (pharmacokinetics)</term><term>Radioisotopes (toxicity)</term><term>Samarium (chemistry)</term><term>Samarium (pharmacokinetics)</term><term>Samarium (toxicity)</term><term>Sodium (chemistry)</term><term>Sodium (pharmacokinetics)</term><term>Sodium (toxicity)</term><term>Thulium (chemistry)</term><term>Thulium (pharmacokinetics)</term><term>Thulium (toxicity)</term><term>Tissue Distribution</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Ytterbium (chemistry)</term><term>Ytterbium (pharmacokinetics)</term><term>Ytterbium (toxicity)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Composés du fluor ()</term><term>Composés du fluor (pharmacocinétique)</term><term>Composés du fluor (toxicité)</term><term>Humains</term><term>Imagerie optique ()</term><term>Lignée cellulaire tumorale</term><term>Luminescence</term><term>Lutétium ()</term><term>Lutétium (pharmacocinétique)</term><term>Lutétium (toxicité)</term><term>Mesures de luminescence ()</term><term>Nanoparticules (analyse)</term><term>Nanoparticules (toxicité)</term><term>Nanoparticules (ultrastructure)</term><term>Radio-isotopes ()</term><term>Radio-isotopes (pharmacocinétique)</term><term>Radio-isotopes (toxicité)</term><term>Répartition dans les tissus</term><term>Samarium ()</term><term>Samarium (pharmacocinétique)</term><term>Samarium (toxicité)</term><term>Sodium ()</term><term>Sodium (pharmacocinétique)</term><term>Sodium (toxicité)</term><term>Souris</term><term>Thulium ()</term><term>Thulium (pharmacocinétique)</term><term>Thulium (toxicité)</term><term>Tomographie par émission monophotonique ()</term><term>Ytterbium ()</term><term>Ytterbium (pharmacocinétique)</term><term>Ytterbium (toxicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorine Compounds</term><term>Lutetium</term><term>Radioisotopes</term><term>Samarium</term><term>Sodium</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Fluorine Compounds</term><term>Lutetium</term><term>Radioisotopes</term><term>Samarium</term><term>Sodium</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Fluorine Compounds</term><term>Lutetium</term><term>Radioisotopes</term><term>Samarium</term><term>Sodium</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Nanoparticules</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Luminescent Measurements</term><term>Optical Imaging</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Composés du fluor</term><term>Lutétium</term><term>Radio-isotopes</term><term>Samarium</term><term>Sodium</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" qualifier="toxicity" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Composés du fluor</term><term>Lutétium</term><term>Nanoparticules</term><term>Radio-isotopes</term><term>Samarium</term><term>Sodium</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Humans</term><term>Luminescence</term><term>Mice</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Composés du fluor</term><term>Humains</term><term>Imagerie optique</term><term>Lignée cellulaire tumorale</term><term>Luminescence</term><term>Lutétium</term><term>Mesures de luminescence</term><term>Nanoparticules</term><term>Radio-isotopes</term><term>Répartition dans les tissus</term><term>Samarium</term><term>Sodium</term><term>Souris</term><term>Thulium</term><term>Tomographie par émission monophotonique</term><term>Ytterbium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Upconversion luminescence (UCL) properties and radioactivity have been integrated into NaLuF(4):(153)Sm,Yb,Tm nanoparticles by a facile one-step hydrothermal method, making these nanoparticles potential candidates for UCL and single-photon emission computed tomography (SPECT) dual-modal bioimaging in vivo. The introduction of small amount of radioactive (153)Sm(3+) can hardly vary the upconversion luminescence properties of the nanoparticles. The as-designed nanoparticles showed very low cytotoxicity, no obvious tissue damage in 7 days, and excellent in vitro and in vivo performances in dual-modal bioimaging. By means of a combination of UCL and SPECT imaging in vivo, the distribution of the nanoparticles in living animals has been studied, and the results indicated that these particles were mainly accumulated in the liver and spleen. Therefore, the concept of (153)Sm(3+)/Yb(3+)/Tm(3+) co-doped NaLuF(4) nanoparticles for UCL and SPECT dual-modality imaging in vivo of whole-body animals may serve as a platform for next-generation probes for ultra-sensitive molecular imaging from the cellular scale to whole-body evaluation. It also introduces an easy methodology to quantify in vivo biodistribution of nanomaterials which still needs further understanding as a community.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Cao, Tianye" sort="Cao, Tianye" uniqKey="Cao T" first="Tianye" last="Cao">Tianye Cao</name><name sortKey="Feng, Wei" sort="Feng, Wei" uniqKey="Feng W" first="Wei" last="Feng">Wei Feng</name><name sortKey="Li, Fuyou" sort="Li, Fuyou" uniqKey="Li F" first="Fuyou" last="Li">Fuyou Li</name><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><name sortKey="Peng, Juanjuan" sort="Peng, Juanjuan" uniqKey="Peng J" first="Juanjuan" last="Peng">Juanjuan Peng</name><name sortKey="Sun, Yun" sort="Sun, Yun" uniqKey="Sun Y" first="Yun" last="Sun">Yun Sun</name><name sortKey="Wu, Yongquan" sort="Wu, Yongquan" uniqKey="Wu Y" first="Yongquan" last="Wu">Yongquan Wu</name><name sortKey="Zhang, Yingjian" sort="Zhang, Yingjian" uniqKey="Zhang Y" first="Yingjian" last="Zhang">Yingjian Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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