Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging.
Identifieur interne : 000622 ( Ncbi/Merge ); précédent : 000621; suivant : 000623Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging.
Auteurs : Yang Yang [République populaire de Chine] ; Yun Sun ; Tianye Cao ; Juanjuan Peng ; Ying Liu ; Yongquan Wu ; Wei Feng ; Yingjian Zhang ; Fuyou LiSource :
- Biomaterials [ 1878-5905 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Composés du fluor (), Composés du fluor (pharmacocinétique), Composés du fluor (toxicité), Humains, Imagerie optique (), Lignée cellulaire tumorale, Luminescence, Lutétium (), Lutétium (pharmacocinétique), Lutétium (toxicité), Mesures de luminescence (), Nanoparticules (analyse), Nanoparticules (toxicité), Nanoparticules (ultrastructure), Radio-isotopes (), Radio-isotopes (pharmacocinétique), Radio-isotopes (toxicité), Répartition dans les tissus, Samarium (), Samarium (pharmacocinétique), Samarium (toxicité), Sodium (), Sodium (pharmacocinétique), Sodium (toxicité), Souris, Thulium (), Thulium (pharmacocinétique), Thulium (toxicité), Tomographie par émission monophotonique (), Ytterbium (), Ytterbium (pharmacocinétique), Ytterbium (toxicité).
- MESH :
- analyse : Nanoparticules.
- pharmacocinétique : Composés du fluor, Lutétium, Radio-isotopes, Samarium, Sodium, Thulium, Ytterbium.
- toxicité : Composés du fluor, Lutétium, Nanoparticules, Radio-isotopes, Samarium, Sodium, Thulium, Ytterbium.
- Animaux, Composés du fluor, Humains, Imagerie optique, Lignée cellulaire tumorale, Luminescence, Lutétium, Mesures de luminescence, Nanoparticules, Radio-isotopes, Répartition dans les tissus, Samarium, Sodium, Souris, Thulium, Tomographie par émission monophotonique, Ytterbium.
English descriptors
- KwdEn :
- Animals, Cell Line, Tumor, Fluorine Compounds (chemistry), Fluorine Compounds (pharmacokinetics), Fluorine Compounds (toxicity), Humans, Luminescence, Luminescent Measurements (methods), Lutetium (chemistry), Lutetium (pharmacokinetics), Lutetium (toxicity), Mice, Nanoparticles (analysis), Nanoparticles (toxicity), Nanoparticles (ultrastructure), Optical Imaging (methods), Radioisotopes (chemistry), Radioisotopes (pharmacokinetics), Radioisotopes (toxicity), Samarium (chemistry), Samarium (pharmacokinetics), Samarium (toxicity), Sodium (chemistry), Sodium (pharmacokinetics), Sodium (toxicity), Thulium (chemistry), Thulium (pharmacokinetics), Thulium (toxicity), Tissue Distribution, Tomography, Emission-Computed, Single-Photon (methods), Ytterbium (chemistry), Ytterbium (pharmacokinetics), Ytterbium (toxicity).
- MESH :
- chemical , chemistry : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- chemical , pharmacokinetics : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- chemical , toxicity : Fluorine Compounds, Lutetium, Radioisotopes, Samarium, Sodium, Thulium, Ytterbium.
- analysis : Nanoparticles.
- methods : Luminescent Measurements, Optical Imaging, Tomography, Emission-Computed, Single-Photon.
- toxicity : Nanoparticles.
- ultrastructure : Nanoparticles.
- Animals, Cell Line, Tumor, Humans, Luminescence, Mice, Tissue Distribution.
Abstract
Upconversion luminescence (UCL) properties and radioactivity have been integrated into NaLuF(4):(153)Sm,Yb,Tm nanoparticles by a facile one-step hydrothermal method, making these nanoparticles potential candidates for UCL and single-photon emission computed tomography (SPECT) dual-modal bioimaging in vivo. The introduction of small amount of radioactive (153)Sm(3+) can hardly vary the upconversion luminescence properties of the nanoparticles. The as-designed nanoparticles showed very low cytotoxicity, no obvious tissue damage in 7 days, and excellent in vitro and in vivo performances in dual-modal bioimaging. By means of a combination of UCL and SPECT imaging in vivo, the distribution of the nanoparticles in living animals has been studied, and the results indicated that these particles were mainly accumulated in the liver and spleen. Therefore, the concept of (153)Sm(3+)/Yb(3+)/Tm(3+) co-doped NaLuF(4) nanoparticles for UCL and SPECT dual-modality imaging in vivo of whole-body animals may serve as a platform for next-generation probes for ultra-sensitive molecular imaging from the cellular scale to whole-body evaluation. It also introduces an easy methodology to quantify in vivo biodistribution of nanomaterials which still needs further understanding as a community.
DOI: 10.1016/j.biomaterials.2012.10.022
PubMed: 23117216
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000329
- to stream PubMed, to step Curation: 000329
- to stream PubMed, to step Checkpoint: 000329
Links to Exploration step
pubmed:23117216Le document en format XML
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<term>Lutetium (chemistry)</term>
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<term>Tomography, Emission-Computed, Single-Photon</term>
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<front><div type="abstract" xml:lang="en">Upconversion luminescence (UCL) properties and radioactivity have been integrated into NaLuF(4):(153)Sm,Yb,Tm nanoparticles by a facile one-step hydrothermal method, making these nanoparticles potential candidates for UCL and single-photon emission computed tomography (SPECT) dual-modal bioimaging in vivo. The introduction of small amount of radioactive (153)Sm(3+) can hardly vary the upconversion luminescence properties of the nanoparticles. The as-designed nanoparticles showed very low cytotoxicity, no obvious tissue damage in 7 days, and excellent in vitro and in vivo performances in dual-modal bioimaging. By means of a combination of UCL and SPECT imaging in vivo, the distribution of the nanoparticles in living animals has been studied, and the results indicated that these particles were mainly accumulated in the liver and spleen. Therefore, the concept of (153)Sm(3+)/Yb(3+)/Tm(3+) co-doped NaLuF(4) nanoparticles for UCL and SPECT dual-modality imaging in vivo of whole-body animals may serve as a platform for next-generation probes for ultra-sensitive molecular imaging from the cellular scale to whole-body evaluation. It also introduces an easy methodology to quantify in vivo biodistribution of nanomaterials which still needs further understanding as a community.</div>
</front>
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<Month>11</Month>
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<DateCompleted><Year>2013</Year>
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<Title>Biomaterials</Title>
<ISOAbbreviation>Biomaterials</ISOAbbreviation>
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<ArticleTitle>Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging.</ArticleTitle>
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<Abstract><AbstractText>Upconversion luminescence (UCL) properties and radioactivity have been integrated into NaLuF(4):(153)Sm,Yb,Tm nanoparticles by a facile one-step hydrothermal method, making these nanoparticles potential candidates for UCL and single-photon emission computed tomography (SPECT) dual-modal bioimaging in vivo. The introduction of small amount of radioactive (153)Sm(3+) can hardly vary the upconversion luminescence properties of the nanoparticles. The as-designed nanoparticles showed very low cytotoxicity, no obvious tissue damage in 7 days, and excellent in vitro and in vivo performances in dual-modal bioimaging. By means of a combination of UCL and SPECT imaging in vivo, the distribution of the nanoparticles in living animals has been studied, and the results indicated that these particles were mainly accumulated in the liver and spleen. Therefore, the concept of (153)Sm(3+)/Yb(3+)/Tm(3+) co-doped NaLuF(4) nanoparticles for UCL and SPECT dual-modality imaging in vivo of whole-body animals may serve as a platform for next-generation probes for ultra-sensitive molecular imaging from the cellular scale to whole-body evaluation. It also introduces an easy methodology to quantify in vivo biodistribution of nanomaterials which still needs further understanding as a community.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation>
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<affiliations><list><country><li>République populaire de Chine</li>
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