A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.
Identifieur interne : 000766 ( Main/Exploration ); précédent : 000765; suivant : 000767A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.
Auteurs : Huaiyong Xing [République populaire de Chine] ; Wenbo Bu ; Qingguo Ren ; Xiangpeng Zheng ; Ming Li ; Shengjian Zhang ; Haiyun Qu ; Zheng Wang ; Yanqing Hua ; Kuaile Zhao ; Liangping Zhou ; Weijun Peng ; Jianlin ShiSource :
- Biomaterials [ 1878-5905 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Facteurs temps, Imagerie du corps entier, Injections veineuses, Lignée cellulaire, Microscopie confocale, Mort cellulaire, Nanoparticules (ultrastructure), Produits de contraste, Répartition dans les tissus, Souris, Spectrométrie de fluorescence (), Spectroscopie proche infrarouge (), Spécificité d'organe, Thulium, Tomodensitométrie (), Ytterbium, Yttrium.
- MESH :
- Animaux, Facteurs temps, Imagerie du corps entier, Injections veineuses, Lignée cellulaire, Microscopie confocale, Mort cellulaire, Nanoparticules, Produits de contraste, Répartition dans les tissus, Souris, Spectrométrie de fluorescence, Spectroscopie proche infrarouge, Spécificité d'organe, Thulium, Tomodensitométrie, Ytterbium, Yttrium.
English descriptors
- KwdEn :
- Animals, Cell Death, Cell Line, Contrast Media, Injections, Intravenous, Mice, Microscopy, Confocal, Nanoparticles (ultrastructure), Organ Specificity, Spectrometry, Fluorescence (methods), Spectroscopy, Near-Infrared (methods), Thulium, Time Factors, Tissue Distribution, Tomography, X-Ray Computed (methods), Whole Body Imaging, Ytterbium, Yttrium.
- MESH :
- chemical : Contrast Media, Thulium, Ytterbium, Yttrium.
- methods : Spectrometry, Fluorescence, Spectroscopy, Near-Infrared, Tomography, X-Ray Computed.
- ultrastructure : Nanoparticles.
- Animals, Cell Death, Cell Line, Injections, Intravenous, Mice, Microscopy, Confocal, Organ Specificity, Time Factors, Tissue Distribution, Whole Body Imaging.
Abstract
Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.
DOI: 10.1016/j.biomaterials.2012.04.002
PubMed: 22538199
Affiliations:
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Le document en format XML
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Chine</country><wicri:regionArea>State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050</wicri:regionArea><wicri:noRegion>Shanghai 200050</wicri:noRegion></affiliation></author><author><name sortKey="Bu, Wenbo" sort="Bu, Wenbo" uniqKey="Bu W" first="Wenbo" last="Bu">Wenbo Bu</name></author><author><name sortKey="Ren, Qingguo" sort="Ren, Qingguo" uniqKey="Ren Q" first="Qingguo" last="Ren">Qingguo Ren</name></author><author><name sortKey="Zheng, Xiangpeng" sort="Zheng, Xiangpeng" uniqKey="Zheng X" first="Xiangpeng" last="Zheng">Xiangpeng Zheng</name></author><author><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name></author><author><name sortKey="Zhang, Shengjian" sort="Zhang, Shengjian" uniqKey="Zhang S" first="Shengjian" last="Zhang">Shengjian Zhang</name></author><author><name sortKey="Qu, Haiyun" sort="Qu, Haiyun" uniqKey="Qu H" first="Haiyun" last="Qu">Haiyun Qu</name></author><author><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name></author><author><name sortKey="Hua, Yanqing" sort="Hua, Yanqing" uniqKey="Hua Y" first="Yanqing" last="Hua">Yanqing Hua</name></author><author><name sortKey="Zhao, Kuaile" sort="Zhao, Kuaile" uniqKey="Zhao K" first="Kuaile" last="Zhao">Kuaile Zhao</name></author><author><name sortKey="Zhou, Liangping" sort="Zhou, Liangping" uniqKey="Zhou L" first="Liangping" last="Zhou">Liangping Zhou</name></author><author><name sortKey="Peng, Weijun" sort="Peng, Weijun" uniqKey="Peng W" first="Weijun" last="Peng">Weijun Peng</name></author><author><name sortKey="Shi, Jianlin" sort="Shi, Jianlin" uniqKey="Shi J" first="Jianlin" last="Shi">Jianlin Shi</name></author></analytic><series><title level="j">Biomaterials</title><idno type="eISSN">1878-5905</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Cell Line</term><term>Contrast Media</term><term>Injections, Intravenous</term><term>Mice</term><term>Microscopy, Confocal</term><term>Nanoparticles (ultrastructure)</term><term>Organ Specificity</term><term>Spectrometry, Fluorescence (methods)</term><term>Spectroscopy, Near-Infrared (methods)</term><term>Thulium</term><term>Time Factors</term><term>Tissue Distribution</term><term>Tomography, X-Ray Computed (methods)</term><term>Whole Body Imaging</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Imagerie du corps entier</term><term>Injections veineuses</term><term>Lignée cellulaire</term><term>Microscopie confocale</term><term>Mort cellulaire</term><term>Nanoparticules (ultrastructure)</term><term>Produits de contraste</term><term>Répartition dans les tissus</term><term>Souris</term><term>Spectrométrie de fluorescence ()</term><term>Spectroscopie proche infrarouge ()</term><term>Spécificité d'organe</term><term>Thulium</term><term>Tomodensitométrie ()</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Contrast Media</term><term>Thulium</term><term>Ytterbium</term><term>Yttrium</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectrometry, Fluorescence</term><term>Spectroscopy, Near-Infrared</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Death</term><term>Cell Line</term><term>Injections, Intravenous</term><term>Mice</term><term>Microscopy, Confocal</term><term>Organ Specificity</term><term>Time Factors</term><term>Tissue Distribution</term><term>Whole Body Imaging</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Imagerie du corps entier</term><term>Injections veineuses</term><term>Lignée cellulaire</term><term>Microscopie confocale</term><term>Mort cellulaire</term><term>Nanoparticules</term><term>Produits de contraste</term><term>Répartition dans les tissus</term><term>Souris</term><term>Spectrométrie de fluorescence</term><term>Spectroscopie proche infrarouge</term><term>Spécificité d'organe</term><term>Thulium</term><term>Tomodensitométrie</term><term>Ytterbium</term><term>Yttrium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Bu, Wenbo" sort="Bu, Wenbo" uniqKey="Bu W" first="Wenbo" last="Bu">Wenbo Bu</name><name sortKey="Hua, Yanqing" sort="Hua, Yanqing" uniqKey="Hua Y" first="Yanqing" last="Hua">Yanqing Hua</name><name sortKey="Li, Ming" sort="Li, Ming" uniqKey="Li M" first="Ming" last="Li">Ming Li</name><name sortKey="Peng, Weijun" sort="Peng, Weijun" uniqKey="Peng W" first="Weijun" last="Peng">Weijun Peng</name><name sortKey="Qu, Haiyun" sort="Qu, Haiyun" uniqKey="Qu H" first="Haiyun" last="Qu">Haiyun Qu</name><name sortKey="Ren, Qingguo" sort="Ren, Qingguo" uniqKey="Ren Q" first="Qingguo" last="Ren">Qingguo Ren</name><name sortKey="Shi, Jianlin" sort="Shi, Jianlin" uniqKey="Shi J" first="Jianlin" last="Shi">Jianlin Shi</name><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name><name sortKey="Zhang, Shengjian" sort="Zhang, Shengjian" uniqKey="Zhang S" first="Shengjian" last="Zhang">Shengjian Zhang</name><name sortKey="Zhao, Kuaile" sort="Zhao, Kuaile" uniqKey="Zhao K" first="Kuaile" last="Zhao">Kuaile Zhao</name><name sortKey="Zheng, Xiangpeng" sort="Zheng, Xiangpeng" uniqKey="Zheng X" first="Xiangpeng" last="Zheng">Xiangpeng Zheng</name><name sortKey="Zhou, Liangping" sort="Zhou, Liangping" uniqKey="Zhou L" first="Liangping" last="Zhou">Liangping Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Xing, Huaiyong" sort="Xing, Huaiyong" uniqKey="Xing H" first="Huaiyong" last="Xing">Huaiyong Xing</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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