A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.
Identifieur interne : 000569 ( Ncbi/Curation ); précédent : 000568; suivant : 000570A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.
Auteurs : Huaiyong Xing [République populaire de Chine] ; Wenbo Bu ; Qingguo Ren ; Xiangpeng Zheng ; Ming Li ; Shengjian Zhang ; Haiyun Qu ; Zheng Wang ; Yanqing Hua ; Kuaile Zhao ; Liangping Zhou ; Weijun Peng ; Jianlin ShiSource :
- Biomaterials [ 1878-5905 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Facteurs temps, Imagerie du corps entier, Injections veineuses, Lignée cellulaire, Microscopie confocale, Mort cellulaire, Nanoparticules (ultrastructure), Produits de contraste, Répartition dans les tissus, Souris, Spectrométrie de fluorescence (), Spectroscopie proche infrarouge (), Spécificité d'organe, Thulium, Tomodensitométrie (), Ytterbium, Yttrium.
- MESH :
- Animaux, Facteurs temps, Imagerie du corps entier, Injections veineuses, Lignée cellulaire, Microscopie confocale, Mort cellulaire, Nanoparticules, Produits de contraste, Répartition dans les tissus, Souris, Spectrométrie de fluorescence, Spectroscopie proche infrarouge, Spécificité d'organe, Thulium, Tomodensitométrie, Ytterbium, Yttrium.
English descriptors
- KwdEn :
- Animals, Cell Death, Cell Line, Contrast Media, Injections, Intravenous, Mice, Microscopy, Confocal, Nanoparticles (ultrastructure), Organ Specificity, Spectrometry, Fluorescence (methods), Spectroscopy, Near-Infrared (methods), Thulium, Time Factors, Tissue Distribution, Tomography, X-Ray Computed (methods), Whole Body Imaging, Ytterbium, Yttrium.
- MESH :
- chemical : Contrast Media, Thulium, Ytterbium, Yttrium.
- methods : Spectrometry, Fluorescence, Spectroscopy, Near-Infrared, Tomography, X-Ray Computed.
- ultrastructure : Nanoparticles.
- Animals, Cell Death, Cell Line, Injections, Intravenous, Mice, Microscopy, Confocal, Organ Specificity, Time Factors, Tissue Distribution, Whole Body Imaging.
Abstract
Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.
DOI: 10.1016/j.biomaterials.2012.04.002
PubMed: 22538199
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pubmed:22538199Le document en format XML
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<front><div type="abstract" xml:lang="en">Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.</div>
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