ThuliumV1, PubMed, Curation, bibRecord, 000370

A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.

Identifieur interne : 000370 ( PubMed/Curation ); précédent : 000369; suivant : 000371

A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.

Auteurs : Huaiyong Xing [République populaire de Chine] ; Wenbo Bu ; Qingguo Ren ; Xiangpeng Zheng ; Ming Li ; Shengjian Zhang ; Haiyun Qu ; Zheng Wang ; Yanqing Hua ; Kuaile Zhao ; Liangping Zhou ; Weijun Peng ; Jianlin Shi

Source :

Biomaterials [ 1878-5905 ] ; 2012.

RBID : pubmed:22538199

Descripteurs français

English descriptors

KwdEn :
- Animals, Cell Death, Cell Line, Contrast Media, Injections, Intravenous, Mice, Microscopy, Confocal, Nanoparticles (ultrastructure), Organ Specificity, Spectrometry, Fluorescence (methods), Spectroscopy, Near-Infrared (methods), Thulium, Time Factors, Tissue Distribution, Tomography, X-Ray Computed (methods), Whole Body Imaging, Ytterbium, Yttrium.
MESH :
- chemical : Contrast Media, Thulium, Ytterbium, Yttrium.
- methods : Spectrometry, Fluorescence, Spectroscopy, Near-Infrared, Tomography, X-Ray Computed.
- ultrastructure : Nanoparticles.
- Animals, Cell Death, Cell Line, Injections, Intravenous, Mice, Microscopy, Confocal, Organ Specificity, Time Factors, Tissue Distribution, Whole Body Imaging.

Abstract

Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.

DOI: 10.1016/j.biomaterials.2012.04.002
PubMed: 22538199

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Le document en format XML

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<term>Microscopy, Confocal</term>
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<term>Spectroscopy, Near-Infrared (methods)</term>
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<term>Lignée cellulaire</term>
<term>Microscopie confocale</term>
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<term>Produits de contraste</term>
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<front><div type="abstract" xml:lang="en">Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.</div>
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A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.

A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.

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Abstract

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