Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) for dual biosensing of pH with CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts)
Identifieur interne : 000294 ( Main/Exploration ); précédent : 000293; suivant : 000295Lanthanide ion (III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) for dual biosensing of pH with CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts)
Auteurs : Yuegao Huang [États-Unis] ; Daniel Coman [États-Unis] ; Meser M. Ali [États-Unis] ; Fahmeed Hyder [États-Unis]Source :
- Contrast media & molecular imaging [ 1555-4309 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Contrast Media, Gadolinium, Heterocyclic Compounds, Lanthanoid Series Elements, Thulium, Ytterbium.
- methods : Diagnostic Imaging.
- Biosensing Techniques, Humans, Hydrogen-Ion Concentration.
Abstract
Relaxivity based magnetic resonance of phosphonated ligands chelated with gadolinium (Gd3+) shows promise for pH imaging. However instead of monitoring the paramagnetic effect of lanthanide complexes on the relaxivity of water protons, biosensor (or molecular) imaging with magnetic resonance is also possible by detecting either the non-exchangeable or the exchangeable protons on the lanthanide complexes themselves. The non-exchangeable protons (e.g., –CHx, where 3≥x≥1) are detected using a three-dimensional chemical shift imaging method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), whereas the exchangeable protons (e.g., –OH or –NHy, where 2≥y≥1) are measured with Chemical Exchange Saturation Transfer (CEST) contrast. Here we tested the feasibility of BIRDS and CEST for pH imaging of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP8−) chelated with thulium (Tm3+) and ytterbium (Yb3+). BIRDS and CEST experiments show that both complexes are responsive to pH and temperature changes. Higher pH and temperature sensitivities are obtained with BIRDS for either complex when using the chemical shift difference between two proton resonances vs. using the chemical shift of a single proton resonance, thereby eliminating the need to use water resonance as reference. While CEST contrast for both agents is linearly dependent on pH within a relatively large range (i.e., 6.3-7.9), much stronger CEST contrast is obtained with YbDOTA-4AmP5− than with TmDOTA-4AmP5−. In addition, we demonstrate the prospect of using BIRDS to calibrate CEST as new platform for quantitative pH imaging.
Url:
DOI: 10.1002/cmmi.1604
PubMed: 24801742
PubMed Central: 4222994
Affiliations:
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(biosensor imaging of redundant deviation in shifts)</title><author><name sortKey="Huang, Yuegao" sort="Huang, Yuegao" uniqKey="Huang Y" first="Yuegao" last="Huang">Yuegao Huang</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Ali, Meser M" sort="Ali, Meser M" uniqKey="Ali M" first="Meser M." last="Ali">Meser M. Ali</name><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Neurology, Henry Ford Hospital, Detroit, MI 48202</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Diagnostic Radiology, Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Biomedical Engineering, Yale University, New Haven, CT 06520</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">Contrast media & molecular imaging</title><idno type="ISSN">1555-4309</idno><idno type="eISSN">1555-4317</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biosensing Techniques</term><term>Contrast Media (chemistry)</term><term>Diagnostic Imaging (methods)</term><term>Gadolinium (chemistry)</term><term>Heterocyclic Compounds (chemistry)</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Lanthanoid Series Elements (chemistry)</term><term>Thulium (chemistry)</term><term>Ytterbium (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Composés hétérocycliques ()</term><term>Concentration en ions d'hydrogène</term><term>Diagnostic par imagerie ()</term><term>Gadolinium ()</term><term>Humains</term><term>Lanthanides ()</term><term>Produits de contraste ()</term><term>Techniques de biocapteur</term><term>Thulium ()</term><term>Ytterbium ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Contrast Media</term><term>Gadolinium</term><term>Heterocyclic Compounds</term><term>Lanthanoid Series Elements</term><term>Thulium</term><term>Ytterbium</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biosensing Techniques</term><term>Humans</term><term>Hydrogen-Ion Concentration</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Composés hétérocycliques</term><term>Concentration en ions d'hydrogène</term><term>Diagnostic par imagerie</term><term>Gadolinium</term><term>Humains</term><term>Lanthanides</term><term>Produits de contraste</term><term>Techniques de biocapteur</term><term>Thulium</term><term>Ytterbium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Relaxivity based magnetic resonance of phosphonated ligands chelated with gadolinium (Gd<sup>3+</sup>) shows promise for pH imaging. However instead of monitoring the paramagnetic effect of lanthanide complexes on the relaxivity of water protons, biosensor (or molecular) imaging with magnetic resonance is also possible by detecting either the non-exchangeable or the exchangeable protons on the lanthanide complexes themselves. The non-exchangeable protons (e.g., –CH<sub>x</sub>, where 3≥x≥1) are detected using a three-dimensional chemical shift imaging method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), whereas the exchangeable protons (e.g., –OH or –NH<sub>y</sub>, where 2≥y≥1) are measured with Chemical Exchange Saturation Transfer (CEST) contrast. Here we tested the feasibility of BIRDS and CEST for pH imaging of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaminophosphonate (DOTA-4AmP<sup>8−</sup>) chelated with thulium (Tm<sup>3+</sup>) and ytterbium (Yb<sup>3+</sup>). BIRDS and CEST experiments show that both complexes are responsive to pH and temperature changes. Higher pH and temperature sensitivities are obtained with BIRDS for either complex when using the chemical shift difference between two proton resonances vs. using the chemical shift of a single proton resonance, thereby eliminating the need to use water resonance as reference. While CEST contrast for both agents is linearly dependent on pH within a relatively large range (i.e., 6.3-7.9), much stronger CEST contrast is obtained with YbDOTA-4AmP<sup>5−</sup> than with TmDOTA-4AmP<sup>5−</sup>. In addition, we demonstrate the prospect of using BIRDS to calibrate CEST as new platform for quantitative pH imaging.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Huang, Yuegao" sort="Huang, Yuegao" uniqKey="Huang Y" first="Yuegao" last="Huang">Yuegao Huang</name></region><name sortKey="Ali, Meser M" sort="Ali, Meser M" uniqKey="Ali M" first="Meser M." last="Ali">Meser M. Ali</name><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><name sortKey="Huang, Yuegao" sort="Huang, Yuegao" uniqKey="Huang Y" first="Yuegao" last="Huang">Yuegao Huang</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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