Combined optical and electrical stimulation of neural tissue in vivo
Identifieur interne : 000F50 ( Main/Exploration ); précédent : 000F49; suivant : 000F51Combined optical and electrical stimulation of neural tissue in vivo
Auteurs : Austin R. Duke [États-Unis] ; Jonathan M. Cayce [États-Unis] ; Jonathan D. Malphrus [États-Unis] ; Peter Konrad [États-Unis] ; Anita Mahadevan-Jansen [États-Unis] ; E. Duco Jansen [États-Unis]Source :
- Journal of Biomedical Optics [ 1083-3668 ] ; 2009.
Abstract
Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold electrical stimulus. Our results indicate a nonlinear relationship between the subthreshold depolarizing electrical stimulus and additional optical energy required to reach stimulation threshold. The change in optical threshold decreases linearly as the delay between the electrical and optical pulses is increased. We have shown that the high spatial precision of INS is maintained for this combined stimulation modality. Results of this study will facilitate the development of applications for infrared neural stimulation, as well as target the efforts to uncover the mechanism by which infrared light activates neural tissue.
Url:
DOI: 10.1117/1.3257230
PubMed: 20059232
PubMed Central: 2789115
Affiliations:
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Duke</name><affiliation wicri:level="2"><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Cayce, Jonathan M" sort="Cayce, Jonathan M" uniqKey="Cayce J" first="Jonathan M." last="Cayce">Jonathan M. 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Duco" last="Jansen">E. Duco Jansen</name><affiliation wicri:level="2"><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="a2">Vanderbilt University, Department of Neurological Surgery, Nashville, Tennessee 37235</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University, Department of Neurological Surgery, Nashville</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of Biomedical Optics</title><idno type="ISSN">1083-3668</idno><idno type="eISSN">1560-2281</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold electrical stimulus. Our results indicate a nonlinear relationship between the subthreshold depolarizing electrical stimulus and additional optical energy required to reach stimulation threshold. The change in optical threshold decreases linearly as the delay between the electrical and optical pulses is increased. We have shown that the high spatial precision of INS is maintained for this combined stimulation modality. Results of this study will facilitate the development of applications for infrared neural stimulation, as well as target the efforts to uncover the mechanism by which infrared light activates neural tissue.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Duke, Austin R" sort="Duke, Austin R" uniqKey="Duke A" first="Austin R." last="Duke">Austin R. Duke</name></region><name sortKey="Cayce, Jonathan M" sort="Cayce, Jonathan M" uniqKey="Cayce J" first="Jonathan M." last="Cayce">Jonathan M. Cayce</name><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E. Duco" last="Jansen">E. Duco Jansen</name><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E. Duco" last="Jansen">E. Duco Jansen</name><name sortKey="Konrad, Peter" sort="Konrad, Peter" uniqKey="Konrad P" first="Peter" last="Konrad">Peter Konrad</name><name sortKey="Konrad, Peter" sort="Konrad, Peter" uniqKey="Konrad P" first="Peter" last="Konrad">Peter Konrad</name><name sortKey="Mahadevan Jansen, Anita" sort="Mahadevan Jansen, Anita" uniqKey="Mahadevan Jansen A" first="Anita" last="Mahadevan-Jansen">Anita Mahadevan-Jansen</name><name sortKey="Mahadevan Jansen, Anita" sort="Mahadevan Jansen, Anita" uniqKey="Mahadevan Jansen A" first="Anita" last="Mahadevan-Jansen">Anita Mahadevan-Jansen</name><name sortKey="Malphrus, Jonathan D" sort="Malphrus, Jonathan D" uniqKey="Malphrus J" first="Jonathan D." last="Malphrus">Jonathan D. Malphrus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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