Combined optical and electrical stimulation of neural tissue in vivo
Identifieur interne : 000068 ( Pmc/Corpus ); précédent : 000067; suivant : 000069Combined optical and electrical stimulation of neural tissue in vivo
Auteurs : Austin R. Duke ; Jonathan M. Cayce ; Jonathan D. Malphrus ; Peter Konrad ; Anita Mahadevan-Jansen ; E. Duco JansenSource :
- Journal of Biomedical Optics [ 1083-3668 ] ; 2009.
Abstract
Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold electrical stimulus. Our results indicate a nonlinear relationship between the subthreshold depolarizing electrical stimulus and additional optical energy required to reach stimulation threshold. The change in optical threshold decreases linearly as the delay between the electrical and optical pulses is increased. We have shown that the high spatial precision of INS is maintained for this combined stimulation modality. Results of this study will facilitate the development of applications for infrared neural stimulation, as well as target the efforts to uncover the mechanism by which infrared light activates neural tissue.
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DOI: 10.1117/1.3257230
PubMed: 20059232
PubMed Central: 2789115
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PMC:2789115Le document en format XML
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<author><name sortKey="Duke, Austin R" sort="Duke, Austin R" uniqKey="Duke A" first="Austin R." last="Duke">Austin R. Duke</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Cayce, Jonathan M" sort="Cayce, Jonathan M" uniqKey="Cayce J" first="Jonathan M." last="Cayce">Jonathan M. Cayce</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Malphrus, Jonathan D" sort="Malphrus, Jonathan D" uniqKey="Malphrus J" first="Jonathan D." last="Malphrus">Jonathan D. Malphrus</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Konrad, Peter" sort="Konrad, Peter" uniqKey="Konrad P" first="Peter" last="Konrad">Peter Konrad</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<affiliation><nlm:aff id="a2">Vanderbilt University, Department of Neurological Surgery, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Mahadevan Jansen, Anita" sort="Mahadevan Jansen, Anita" uniqKey="Mahadevan Jansen A" first="Anita" last="Mahadevan-Jansen">Anita Mahadevan-Jansen</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<affiliation><nlm:aff id="a2">Vanderbilt University, Department of Neurological Surgery, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Jansen, E Duco" sort="Jansen, E Duco" uniqKey="Jansen E" first="E. Duco" last="Jansen">E. Duco Jansen</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Duke, Austin R" sort="Duke, Austin R" uniqKey="Duke A" first="Austin R." last="Duke">Austin R. Duke</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<author><name sortKey="Cayce, Jonathan M" sort="Cayce, Jonathan M" uniqKey="Cayce J" first="Jonathan M." last="Cayce">Jonathan M. Cayce</name>
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<author><name sortKey="Konrad, Peter" sort="Konrad, Peter" uniqKey="Konrad P" first="Peter" last="Konrad">Peter Konrad</name>
<affiliation><nlm:aff id="a1">Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p>Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold electrical stimulus. Our results indicate a nonlinear relationship between the subthreshold depolarizing electrical stimulus and additional optical energy required to reach stimulation threshold. The change in optical threshold decreases linearly as the delay between the electrical and optical pulses is increased. We have shown that the high spatial precision of INS is maintained for this combined stimulation modality. Results of this study will facilitate the development of applications for infrared neural stimulation, as well as target the efforts to uncover the mechanism by which infrared light activates neural tissue.</p>
</div>
</front>
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<pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biomed Opt</journal-id>
<journal-title-group><journal-title>Journal of Biomedical Optics</journal-title>
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<issn pub-type="ppub">1083-3668</issn>
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<title-group><article-title>Combined optical and electrical stimulation of neural tissue <italic>in vivo</italic>
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<contrib-group><contrib contrib-type="author"><name><surname>Duke</surname>
<given-names>Austin R.</given-names>
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<contrib contrib-type="author"><name><surname>Cayce</surname>
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<contrib contrib-type="author"><name><surname>Malphrus</surname>
<given-names>Jonathan D.</given-names>
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<contrib contrib-type="author"><name><surname>Konrad</surname>
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<contrib contrib-type="author"><name><surname>Mahadevan-Jansen</surname>
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<given-names>E. Duco</given-names>
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<aff id="a1"><label>1</label>
Vanderbilt University, Department of Biomedical Engineering, VU Station B, Box 351631, Nashville, Tennessee 37235</aff>
<aff id="a2"><label>2</label>
Vanderbilt University, Department of Neurological Surgery, Nashville, Tennessee 37235</aff>
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<author-notes><fn id="n2"><label>b)</label>
<p>Tel: 615-343-1911; Fax: 615-343-7919; <email>duco.jansen@vanderbilt.edu</email>
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<pub-date pub-type="ppub"><season>November-December</season>
<year>2009</year>
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<pub-date pub-type="epub"><day>10</day>
<month>11</month>
<year>2009</year>
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<volume>14</volume>
<issue>6</issue>
<elocation-id>060501</elocation-id>
<history><date date-type="received"><day>15</day>
<month>6</month>
<year>2009</year>
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<date date-type="rev-recd"><day>13</day>
<month>8</month>
<year>2009</year>
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<date date-type="accepted"><day>08</day>
<month>9</month>
<year>2009</year>
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<permissions><copyright-statement>Copyright © 2009 Society of Photo-Optical Instrumentation Engineers</copyright-statement>
<copyright-year>2009</copyright-year>
<copyright-holder>Society of Photo-Optical Instrumentation Engineers</copyright-holder>
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<abstract><p>Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids the limitations of traditional electrical methods such as necessity of contact, presence of a stimulation artifact, and relatively poor spatial precision. Infrared neural stimulation (INS) is, however, limited by a 2:1 ratio of threshold radiant exposures for damage to that for stimulation. We have shown that this ratio is increased to nearly 6:1 by combining the infrared pulse with a subthreshold electrical stimulus. Our results indicate a nonlinear relationship between the subthreshold depolarizing electrical stimulus and additional optical energy required to reach stimulation threshold. The change in optical threshold decreases linearly as the delay between the electrical and optical pulses is increased. We have shown that the high spatial precision of INS is maintained for this combined stimulation modality. Results of this study will facilitate the development of applications for infrared neural stimulation, as well as target the efforts to uncover the mechanism by which infrared light activates neural tissue.</p>
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