ThuliumV1, Main, Exploration, bibRecord, 000924

Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Identifieur interne : 000924 ( Main/Exploration ); précédent : 000923; suivant : 000925

Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Auteurs : Marianne Liebi [Suisse] ; Joachim Kohlbrecher [Suisse] ; Takashi Ishikawa [Suisse] ; Peter Fischer [Suisse] ; Peter Walde [Suisse] ; Erich J. Windhab [Suisse]

Source :

Langmuir [ 0743-7463 ] ; 2012.

RBID : Pascal:12-0335971

Descripteurs français

Pascal (Inist)
- Cholestérol, Disque, Complexe, Thulium, Ion, Champ magnétique, Transition phase, Température transition, Microscopie électronique transmission, Diffusion neutron centrale, Phospholipide, Phénomène transitoire.
Wicri :
- topic : Disque.

English descriptors

KwdEn :
- Cholesterol, Complexes, Disk, Ions, Magnetic field, Phase transitions, Phospholipid, Small angle neutron scattering, Thulium, Transients, Transition temperature, Transmission electron microscopy.

Abstract

Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm³⁺), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm³⁺, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm³⁺ complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm³⁺ aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.

Affiliations:

Suisse

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cholesterol</term>
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<term>Phase transitions</term>
<term>Phospholipid</term>
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<term>Transition phase</term>
<term>Température transition</term>
<term>Microscopie électronique transmission</term>
<term>Diffusion neutron centrale</term>
<term>Phospholipide</term>
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<front><div type="abstract" xml:lang="en">Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm<sup>3+</sup>
), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm<sup>3+</sup>
, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm<sup>3+</sup>
 complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm<sup>3+</sup>
 aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</div>
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<tree><country name="Suisse"><noRegion><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name>
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<name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name>
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Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri