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Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Identifieur interne : 000136 ( Pascal/Corpus ); précédent : 000135; suivant : 000137

Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions

Auteurs : Marianne Liebi ; Joachim Kohlbrecher ; Takashi Ishikawa ; Peter Fischer ; Peter Walde ; Erich J. Windhab

Source :

RBID : Pascal:12-0335971

Descripteurs français

English descriptors

Abstract

Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm3+), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm3+, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm3+ complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm3+ aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A08 01  1  ENG  @1 Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions
A11 01  1    @1 LIEBI (Marianne)
A11 02  1    @1 KOHLBRECHER (Joachim)
A11 03  1    @1 ISHIKAWA (Takashi)
A11 04  1    @1 FISCHER (Peter)
A11 05  1    @1 WALDE (Peter)
A11 06  1    @1 WINDHAB (Erich J.)
A14 01      @1 Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9 @2 8092 Zurich @3 CHE @Z 1 aut. @Z 4 aut. @Z 6 aut.
A14 02      @1 Laboratory for Neutron Scattering, Paul Scherrer Institute @2 5232 Villigen PSI @3 CHE @Z 2 aut.
A14 03      @1 Biomolecular Research Laboratory, Paul Scherrer Institute @2 5232 Villigen PSI @3 CHE @Z 3 aut.
A14 04      @1 Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10 @2 8093 Zurich @3 CHE @Z 5 aut.
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A21       @1 2012
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A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
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C01 01    ENG  @0 Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm3+), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm3+, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm3+ complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm3+ aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.
C02 01  X    @0 001C01
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C03 01  X  ENG  @0 Cholesterol @2 NK @5 01
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C03 02  X  FRE  @0 Disque @5 02
C03 02  X  ENG  @0 Disk @5 02
C03 02  X  SPA  @0 Disco @5 02
C03 03  X  FRE  @0 Complexe @2 NA @5 03
C03 03  X  ENG  @0 Complexes @2 NA @5 03
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C03 06  X  SPA  @0 Campo magnético @5 06
C03 07  X  FRE  @0 Transition phase @5 07
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C03 07  X  SPA  @0 Transición fase @5 07
C03 08  X  FRE  @0 Température transition @5 08
C03 08  X  ENG  @0 Transition temperature @5 08
C03 08  X  SPA  @0 Temperatura transición @5 08
C03 09  X  FRE  @0 Microscopie électronique transmission @5 09
C03 09  X  ENG  @0 Transmission electron microscopy @5 09
C03 09  X  SPA  @0 Microscopía electrónica transmisión @5 09
C03 10  X  FRE  @0 Diffusion neutron centrale @5 10
C03 10  X  ENG  @0 Small angle neutron scattering @5 10
C03 10  X  SPA  @0 Difusión neutrón central @5 10
C03 11  X  FRE  @0 Phospholipide @5 11
C03 11  X  ENG  @0 Phospholipid @5 11
C03 11  X  SPA  @0 Fosfolípido @5 11
C03 12  X  FRE  @0 Phénomène transitoire @5 12
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N21       @1 254
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Format Inist (serveur)

NO : PASCAL 12-0335971 INIST
ET : Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions
AU : LIEBI (Marianne); KOHLBRECHER (Joachim); ISHIKAWA (Takashi); FISCHER (Peter); WALDE (Peter); WINDHAB (Erich J.)
AF : Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9/8092 Zurich/Suisse (1 aut., 4 aut., 6 aut.); Laboratory for Neutron Scattering, Paul Scherrer Institute/5232 Villigen PSI/Suisse (2 aut.); Biomolecular Research Laboratory, Paul Scherrer Institute/5232 Villigen PSI/Suisse (3 aut.); Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10/8093 Zurich/Suisse (5 aut.)
DT : Publication en série; Niveau analytique
SO : Langmuir; ISSN 0743-7463; Coden LANGD5; Etats-Unis; Da. 2012; Vol. 28; No. 29; Pp. 10905-10915; Bibl. 67 ref.
LA : Anglais
EA : Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm3+), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm3+, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm3+ complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm3+ aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.
CC : 001C01
FD : Cholestérol; Disque; Complexe; Thulium; Ion; Champ magnétique; Transition phase; Température transition; Microscopie électronique transmission; Diffusion neutron centrale; Phospholipide; Phénomène transitoire
ED : Cholesterol; Disk; Complexes; Thulium; Ions; Magnetic field; Phase transitions; Transition temperature; Transmission electron microscopy; Small angle neutron scattering; Phospholipid; Transients
SD : Colesterol; Disco; Complejo; Tulio; Ión; Campo magnético; Transición fase; Temperatura transición; Microscopía electrónica transmisión; Difusión neutrón central; Fosfolípido; Fenómeno transitorio
LO : INIST-20642.354000506692590330
ID : 12-0335971

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Pascal:12-0335971

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<div type="abstract" xml:lang="en">Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm
<sup>3+</sup>
), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm
<sup>3+</sup>
, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm
<sup>3+</sup>
complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm
<sup>3+</sup>
aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</div>
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<s0>Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm
<sup>3+</sup>
), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm
<sup>3+</sup>
, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm
<sup>3+</sup>
complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm
<sup>3+</sup>
aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>001C01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Cholestérol</s0>
<s2>NK</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Cholesterol</s0>
<s2>NK</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Colesterol</s0>
<s2>NK</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Disque</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Disk</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Disco</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Complexe</s0>
<s2>NA</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Complexes</s0>
<s2>NA</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Complejo</s0>
<s2>NA</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE">
<s0>Thulium</s0>
<s2>NC</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Thulium</s0>
<s2>NC</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Tulio</s0>
<s2>NC</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Ion</s0>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Ions</s0>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Ión</s0>
<s2>NA</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Champ magnétique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Magnetic field</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Campo magnético</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Transition phase</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Phase transitions</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Transición fase</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Température transition</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Transition temperature</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Temperatura transición</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Microscopie électronique transmission</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Transmission electron microscopy</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Microscopía electrónica transmisión</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Diffusion neutron centrale</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Small angle neutron scattering</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Difusión neutrón central</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Phospholipide</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Phospholipid</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Fosfolípido</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Phénomène transitoire</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Transients</s0>
<s5>12</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Fenómeno transitorio</s0>
<s5>12</s5>
</fC03>
<fN21>
<s1>254</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
<server>
<NO>PASCAL 12-0335971 INIST</NO>
<ET>Cholesterol Increases the Magnetic Aligning of Bicellar Disks from an Aqueous Mixture of DMPC and DMPE-DTPA with Complexed Thulium Ions</ET>
<AU>LIEBI (Marianne); KOHLBRECHER (Joachim); ISHIKAWA (Takashi); FISCHER (Peter); WALDE (Peter); WINDHAB (Erich J.)</AU>
<AF>Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9/8092 Zurich/Suisse (1 aut., 4 aut., 6 aut.); Laboratory for Neutron Scattering, Paul Scherrer Institute/5232 Villigen PSI/Suisse (2 aut.); Biomolecular Research Laboratory, Paul Scherrer Institute/5232 Villigen PSI/Suisse (3 aut.); Department of Materials, ETH Zurich, Wolfgang-Pauli-Strasse 10/8093 Zurich/Suisse (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Langmuir; ISSN 0743-7463; Coden LANGD5; Etats-Unis; Da. 2012; Vol. 28; No. 29; Pp. 10905-10915; Bibl. 67 ref.</SO>
<LA>Anglais</LA>
<EA>Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm
<sup>3+</sup>
), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5- 22 °C), as shown by cryo-transmission electron microscopy (cryoTEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm
<sup>3+</sup>
, allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm
<sup>3+</sup>
complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm
<sup>3+</sup>
aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</EA>
<CC>001C01</CC>
<FD>Cholestérol; Disque; Complexe; Thulium; Ion; Champ magnétique; Transition phase; Température transition; Microscopie électronique transmission; Diffusion neutron centrale; Phospholipide; Phénomène transitoire</FD>
<ED>Cholesterol; Disk; Complexes; Thulium; Ions; Magnetic field; Phase transitions; Transition temperature; Transmission electron microscopy; Small angle neutron scattering; Phospholipid; Transients</ED>
<SD>Colesterol; Disco; Complejo; Tulio; Ión; Campo magnético; Transición fase; Temperatura transición; Microscopía electrónica transmisión; Difusión neutrón central; Fosfolípido; Fenómeno transitorio</SD>
<LO>INIST-20642.354000506692590330</LO>
<ID>12-0335971</ID>
</server>
</inist>
</record>

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