Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Identifieur interne : 000759 ( Main/Exploration ); précédent : 000758; suivant : 000760Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Auteurs : Marianne Liebi [Suisse] ; Joachim Kohlbrecher ; Takashi Ishikawa ; Peter Fischer ; Peter Walde ; Erich J. WindhabSource :
- Langmuir : the ACS journal of surfaces and colloids [ 1520-5827 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Cholesterol (chemistry), Dimyristoylphosphatidylcholine (chemistry), Ions (chemistry), Magnetic Fields, Models, Molecular, Organometallic Compounds (chemical synthesis), Organometallic Compounds (chemistry), Particle Size, Pentetic Acid (chemistry), Surface Properties, Temperature, Thulium (chemistry), Water (chemistry).
- MESH :
- chemical , chemical synthesis : Organometallic Compounds.
- chemical , chemistry : Cholesterol, Dimyristoylphosphatidylcholine, Ions, Organometallic Compounds, Pentetic Acid, Thulium, Water.
- Magnetic Fields, Models, Molecular, Particle Size, Surface Properties, Temperature.
Abstract
Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.
DOI: 10.1021/la3019327
PubMed: 22724540
Affiliations:
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Le document en format XML
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Windhab</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1021/la3019327</idno><idno type="RBID">pubmed:22724540</idno><idno type="pmid">22724540</idno><idno type="wicri:Area/PubMed/Corpus">000356</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000356</idno><idno type="wicri:Area/PubMed/Curation">000356</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000356</idno><idno type="wicri:Area/PubMed/Checkpoint">000356</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000356</idno><idno type="wicri:Area/Ncbi/Merge">000588</idno><idno type="wicri:Area/Ncbi/Curation">000588</idno><idno type="wicri:Area/Ncbi/Checkpoint">000588</idno><idno type="wicri:Area/Main/Merge">000760</idno><idno type="wicri:Area/Main/Curation">000759</idno><idno type="wicri:Area/Main/Exploration">000759</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.</title><author><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Food Process Engineering, ETH Zurich, Schmelzbergstrasse 9, 8092 Zurich</wicri:regionArea><wicri:noRegion>8092 Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Kohlbrecher, Joachim" sort="Kohlbrecher, Joachim" uniqKey="Kohlbrecher J" first="Joachim" last="Kohlbrecher">Joachim Kohlbrecher</name></author><author><name sortKey="Ishikawa, Takashi" sort="Ishikawa, Takashi" uniqKey="Ishikawa T" first="Takashi" last="Ishikawa">Takashi Ishikawa</name></author><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></author><author><name sortKey="Walde, Peter" sort="Walde, Peter" uniqKey="Walde P" first="Peter" last="Walde">Peter Walde</name></author><author><name sortKey="Windhab, Erich J" sort="Windhab, Erich J" uniqKey="Windhab E" first="Erich J" last="Windhab">Erich J. Windhab</name></author></analytic><series><title level="j">Langmuir : the ACS journal of surfaces and colloids</title><idno type="eISSN">1520-5827</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cholesterol (chemistry)</term><term>Dimyristoylphosphatidylcholine (chemistry)</term><term>Ions (chemistry)</term><term>Magnetic Fields</term><term>Models, Molecular</term><term>Organometallic Compounds (chemical synthesis)</term><term>Organometallic Compounds (chemistry)</term><term>Particle Size</term><term>Pentetic Acid (chemistry)</term><term>Surface Properties</term><term>Temperature</term><term>Thulium (chemistry)</term><term>Water (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide pentétique ()</term><term>Champs magnétiques</term><term>Cholestérol ()</term><term>Composés organométalliques ()</term><term>Composés organométalliques (synthèse chimique)</term><term>Dimyristoylphosphatidylcholine ()</term><term>Eau ()</term><term>Ions ()</term><term>Modèles moléculaires</term><term>Propriétés de surface</term><term>Taille de particule</term><term>Température</term><term>Thulium ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Organometallic Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cholesterol</term><term>Dimyristoylphosphatidylcholine</term><term>Ions</term><term>Organometallic Compounds</term><term>Pentetic Acid</term><term>Thulium</term><term>Water</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Composés organométalliques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Magnetic Fields</term><term>Models, Molecular</term><term>Particle Size</term><term>Surface Properties</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide pentétique</term><term>Champs magnétiques</term><term>Cholestérol</term><term>Composés organométalliques</term><term>Dimyristoylphosphatidylcholine</term><term>Eau</term><term>Ions</term><term>Modèles moléculaires</term><term>Propriétés de surface</term><term>Taille de particule</term><term>Température</term><term>Thulium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name><name sortKey="Ishikawa, Takashi" sort="Ishikawa, Takashi" uniqKey="Ishikawa T" first="Takashi" last="Ishikawa">Takashi Ishikawa</name><name sortKey="Kohlbrecher, Joachim" sort="Kohlbrecher, Joachim" uniqKey="Kohlbrecher J" first="Joachim" last="Kohlbrecher">Joachim Kohlbrecher</name><name sortKey="Walde, Peter" sort="Walde, Peter" uniqKey="Walde P" first="Peter" last="Walde">Peter Walde</name><name sortKey="Windhab, Erich J" sort="Windhab, Erich J" uniqKey="Windhab E" first="Erich J" last="Windhab">Erich J. Windhab</name></noCountry><country name="Suisse"><noRegion><name sortKey="Liebi, Marianne" sort="Liebi, Marianne" uniqKey="Liebi M" first="Marianne" last="Liebi">Marianne Liebi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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