Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Identifieur interne : 000588 ( Ncbi/Curation ); précédent : 000587; suivant : 000589Cholesterol increases the magnetic aligning of bicellar disks from an aqueous mixture of DMPC and DMPE-DTPA with complexed thulium ions.
Auteurs : Marianne Liebi [Suisse] ; Joachim Kohlbrecher ; Takashi Ishikawa ; Peter Fischer ; Peter Walde ; Erich J. WindhabSource :
- Langmuir : the ACS journal of surfaces and colloids [ 1520-5827 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Cholesterol (chemistry), Dimyristoylphosphatidylcholine (chemistry), Ions (chemistry), Magnetic Fields, Models, Molecular, Organometallic Compounds (chemical synthesis), Organometallic Compounds (chemistry), Particle Size, Pentetic Acid (chemistry), Surface Properties, Temperature, Thulium (chemistry), Water (chemistry).
- MESH :
- chemical , chemical synthesis : Organometallic Compounds.
- chemical , chemistry : Cholesterol, Dimyristoylphosphatidylcholine, Ions, Organometallic Compounds, Pentetic Acid, Thulium, Water.
- Magnetic Fields, Models, Molecular, Particle Size, Surface Properties, Temperature.
Abstract
Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.
DOI: 10.1021/la3019327
PubMed: 22724540
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pubmed:22724540Le document en format XML
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<term>Magnetic Fields</term>
<term>Models, Molecular</term>
<term>Organometallic Compounds (chemical synthesis)</term>
<term>Organometallic Compounds (chemistry)</term>
<term>Particle Size</term>
<term>Pentetic Acid (chemistry)</term>
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<term>Temperature</term>
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<term>Water (chemistry)</term>
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<term>Cholestérol ()</term>
<term>Composés organométalliques ()</term>
<term>Composés organométalliques (synthèse chimique)</term>
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<term>Ions ()</term>
<term>Modèles moléculaires</term>
<term>Propriétés de surface</term>
<term>Taille de particule</term>
<term>Température</term>
<term>Thulium ()</term>
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<term>Temperature</term>
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<term>Dimyristoylphosphatidylcholine</term>
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<term>Ions</term>
<term>Modèles moléculaires</term>
<term>Propriétés de surface</term>
<term>Taille de particule</term>
<term>Température</term>
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<front><div type="abstract" xml:lang="en">Aqueous mixtures of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-diethylenetriamine pentaacetate (DMPE-DTPA) with complexed thulium ions (Tm(3+)), and cholesterol with varying molar ratio were studied at different temperatures in the presence and absence of a magnetic field. For mixtures without cholesterol weakly magnetically alignable small disks, so-called bicelles, are formed at temperatures below the phase transition temperature (5-22 °C), as shown by cryo-transmission electron microscopy (cryo-TEM) and small-angle neutron scattering (SANS). In presence of 16 mol % cholesterol the disk size and the magnetic alignability were larger within the entire temperature range studied (5-40 °C). Cholesterol acts as a spacer between DMPE-DTPA with complexed Tm(3+), allowing these molecules to integrate more frequently into the planar part of the bicelles. Replacing DMPC partially by cholesterol thus lead to an increase in magnetic aligning by a higher amount of the magnetic handles (Tm(3+) complexed to DMPE-DTPA) in the plane and by an increased number of phospholipids in the enlarged bicelles. The magnetic aligning was most pronounced at 5 °C. The temperature-dependent structural changes of the DMPC/cholesterol/DMPE-DTPA/Tm(3+) aqueous mixtures are complex, including the transient appearance of holes in the disks at intermediate temperatures.</div>
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